The AccuBoost system is a new innovation for delivering targeted radiation boost treatment to the tissue surrounding the tumor bed following lumpectomy for early-stage breast cancer. It uses applicators and real-time image guidance to reliably target the boost dose to the lumpectomy cavity without relying on the surgical scar. Studies show AccuBoost improves cosmetic outcomes, reduces complications, and lowers the dose to healthy tissues like lungs and chest wall compared to traditional electron boost treatments. The system's integration of imaging and radiation delivery allows for exact targeting of the treatment area.

1. AccuBoost®
The first innovation in Breast Boost in over 30 years.
A new option when making an important decision...
Women with early stage breast cancer increasingly choose to treat the cancer and save their breast.
Breast conservation therapy (BCT) starts with the surgical removal of cancerous tissue in a procedure
known as lumpectomy. Lumpectomy is followed by daily sessions of radiation therapy to the whole
breast for six weeks.
Based on over three decades of experience1, whole breast irradiation (WBI) is widely accepted as the
“gold standard” for breast radiotherapy. The BCT protocol also requires additional localized radiation,
known as the “boost” dose, aimed only at the tissue surrounding the tumor bed, the most-likely site of
future recurrence. 2
The Need for Boost Dose Improvements
Today, the boost dose is aimed at the surgical site mainly by using the surgical scar left on the skin.
Unfortunately, in most cases, the surgical scar does not provide a good reference point for the location
of the lumpectomy and is unrelated to the lumpectomy cavity’s shape and size. In fact, recent reports3
indicate that in more than 50% of cases analyzed, the boost dose aimed via the surgical scar misses the
intended target.
AccuBoost’s Strive for Perfection...
AccuBoost® solves this problem by reliably and accurately targeting the boost dose through the
combination of a noninvasive method of delivering a well-focused radiation beam and the power of
real-time image guidance. Additionally, AccuBoost strongly limits unintentional exposure to otherwise
healthy tissue and minimizes radiation-related side effects.
image & target treat vertically treat horizontally accumulate dose
to target

2. AccuBoost®
The first innovation in Breast Boost in over 30 years.
Treat the breast, spare the heart...
AccuBoost® uses applicators placed on the x-ray imaging paddles that are used to immobilize
and image the breast. The applicators receive a temporary radioactive source from a computer-
controlled afterloader and deliver beams of radiation to the breast tissue that lies directly in
front of them. By properly imaging the surgical site and positioning the applicator at various
angles around the breast, a therapeutic dose is accumulated in the target tissue without over-
exposing the skin and intervening tissue. A recent multi-institutional study shows the use of
AccuBoost improved cosmetic outcome and resulted in fewer complications during the acute
phase.4
Because AccuBoost® directs the radiation parallel to the chest wall, the exposure to the organs
below the chest wall is substantially reduced when compared to traditional electron boost
treatment which directs the radiation directly at the chest wall. Recent studies4 show that the
AccuBoost process lowers the dose to the lungs and chest wall by roughly 7 - 10 times when
compared with traditional “en face” electron boost. Furthermore, the volume of healthy breast
tissue that needs to be targeted and treated is reduced.5
Hitting the Bull’s Eye – The Importance of IGRT
In the AccuBoost design, the radiographic imaging equipment and the radiation delivery
hardware share a common platform, making dose targeting accurate and eliminating daily
patient positioning “guess-work”. The real-time image guided radiation therapy (IGRT) feature
of AccuBoost allows exact targeting of the tissue, giving rise to the AccuBoost slogan: See
what you treat... Treat what you see.
REFERENCES :1 Bartelink, N Engl J Med, 2001. 2 Romestaing, J Clin Oncol, 1997. 3 Oh, Int J Radiation Oncology Biol
Phys, 2006. 4 Hamid, Int J Ratiation Oncology Biol Phys, In Press. 5 Sioshansi, Int J Radiation Oncology Biol Phys, 2011.
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