Bilirubin metabolism involves its source from the breakdown of heme, transport to the liver, hepatic uptake and conjugation then secretion into bile, and intestinal elimination. The document discusses bilirubin metabolism, the etiology and pathogenesis of jaundice, and the distinction between direct and indirect hyperbilirubinemia.

1. Hepatobiliary system

2. Topic for Discussion
•Bilirubin metabolism
•Jaundice
•Direct vs indirect jaundice

3. Bilirubin metabolism
Normal metabolism of bilirubin involves:
• Source
• Transport
• Hepatic phase-hepatic uptake, conjugation and secretion in bile.
• Intestinal phase.

4. Bilirubin
metabolism
and
elimination

5. Hepatic phase of bilirubin transport

6. Etiology of jaundice

9. Direct vs indirect hyperbilirubinemia

10. • Describe bilirubin metabolism.
• Enumerate the etiology and pathogenesis of jaundice
• Distinguish between direct vs Indirect Hyperbilirubinemia.

11. THANK YOU