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Describe how removing water from a hydrophobic binding site or ligand can facilitate ligand
binding.
Solution
Hydrophobic is water hating so it cannot interact with water or it stay unmixed. Just like water in
oil where water obstructs interaction between oil, water blocks the hydrophobic binding site. So
the ligand cannot bind to the site.

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  • 1. Describe how removing water from a hydrophobic binding site or ligand can facilitate ligand binding. Solution Hydrophobic is water hating so it cannot interact with water or it stay unmixed. Just like water in oil where water obstructs interaction between oil, water blocks the hydrophobic binding site. So the ligand cannot bind to the site.