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Effect of augmenting cumulative toxicity on 
11/27/2014 1 
progeny
Effect of augmenting cumulative 
toxicity on progeny 
By, 
Dr.Shwetha.K 
II yr PG Scholar 
Dept.of Agadatantra 
SDMCA,Udupi 
Under the guidance of, 
Dr.K.Shobha Bhat 
Associate professor 
Dept.of Agadatantra 
SDMCA,Udupi
Introduction 
• To become a mother of a healthy child - most 
cherished desire of every woman. 
• She bears the entire responsibility of progeny 
from conception to the maturity of fetus. 
Effect of augmenting cumulative toxicity on 
11/27/2014 3 
progeny
• ...ऋतु क्षेत्राम्बुबीजानाां सामाग्र्यादन्कुरो ुथा य ा | 
(सु.शा.२/३३) 
Effect of augmenting cumulative toxicity on 
11/27/2014 4 
progeny
• The drastic change in lifestyle and habits of 
people during present modern era - sufferings 
from many angles, most alarming being their 
health & health of their offsprings. 
Effect of augmenting cumulative toxicity on 
11/27/2014 5 
progeny
• Maternal exposure to different mediums like 
 alcohol 
tobacco 
harmful medications accumulation 
certain chemicals of environment of toxins 
the incompatible foods inside the 
 the high doses of radiation body 
Effect of augmenting cumulative toxicity on 
11/27/2014 6 
progeny
An estimated 270000 
newborns die during the first 
28 days of life every year 
from congenital anomalies. 
In 2010, 2.7 million neonatal 
deaths documented in 193 
countries. 
Globally, 10 million infants & 
children die each year before 
5th birthday. 
Effect of augmenting cumulative toxicity on 
11/27/2014 7 
progeny
Modes of exposure 
Occupa 
tional 
Environm 
ental 
Food & 
drinks 
Chemical 
& drugs 
Metals & 
minerals 
Effect of augmenting cumulative toxicity on 
11/27/2014 8 
progeny
Environmental cause 
Polluted 
water 
Polluted air 
Radiational 
Effect of augmenting cumulative toxicity on 
11/27/2014 9 
progeny
• Hiroshima & Nagasaki 
• Minamata syndrome 
• Endosulfan issue 
Effect of augmenting cumulative toxicity on 
11/27/2014 10 
progeny
• Mobile phone radiation exposure in the womb 
can affect the brain development of offspring 
and potentially lead to neurobehavioral 
disorders (in mice). 
(www.nature.com/srep/2012) 
Effect of augmenting cumulative toxicity on 
11/27/2014 11 
progeny
Eating Habits 
Junk foods/fast food 
Carbonated 
Beverages 
Incompatible foods 
Fruits & vegetables 
Soft drinks - ↑asthma & 
↓ bone development 
(sciencenordic.com) 
(www.families.com/blog) 
Junk food – alter brain chemistry as 
opium & heroine 
Alter dopamine secretion, 
↑tolerance to sugar & fats 
(http://www.hindustantimes.com) 
Effect of augmenting cumulative toxicity on 
11/27/2014 12 
progeny
Exposure of 
mother/father to 
pesticides before 
conception or during 
pregnancy 
In utero exposure Congenital 
anomalies 
fetal death growth retardation eye defects, 
spontaneous abortion a small-for-gestational 
age baby 
limb reduction 
early childhood cancer low birth weight urogenital defects 
reduced length hypospadias 
small head 
circumference. 
cryptorchidism 
orofacial clefts 
heart defects 
CNS defects 
Effect of augmenting cumulative toxicity on 
(www11./w27/h20o1.4int/ceh) 13 
progeny
Prenatal exposure→ fetal brain →both structurally & 
functionally 
Child suffers from fetal alcohol syndrome 
Anatomical changes in brain- basal ganglia, corpus callosum, 
cerebellum and hippocampus 
Functionally→ deficits in cognitive & behavioral functions, 
learning & memory 
Effect of augmenting cumulative toxicity on 
11/27/2014 14 
(www.niaaa.nih.gov/alcohol-health) 
progeny
Tobacco 
Prenatal 
exposure 
to tobacco 
Anxiety & 
depression of 
Low birth 
weight, 
Intrauterine 
death 
early 
childhood 
Signs of CNS 
stress 
Low IQ level 
More 
excitable, ↑ 
muscle 
tension 
( Salihu and Wilson, 2007) 
(Robinson et al., 2008) 
(Law et al., 2003) 
(Fried, 2002; Herrmann, King & 
Weitzman, 2008) 
Effect of augmenting cumulative toxicity on 
11/27/2014 15 
progeny
आयुर्वेदन्कुीय वर्वमशश 
यत्स् ार्वथांजङ्गम ृत्रत्रमांर्वा दन्कुेहादन्कुशेषांयदन्कुननगशतांतत्।जीर्णं 
वर्वषघ्नौषधिभिहशतांर्वा दन्कुार्वाग्ननर्वातातपशावषतांर्वा ॥स्र्विार्वता र्वा 
गुर्णवर्वप्रहीनांवर्वषांहह दन्कुूषीवर्वषतामुपैनत ।र्वीयाशल्पपिार्वारोन 
ननपातयेत्तत् फाव्रुतांर्वषशगर्णानुबग्रोि ॥ 
(सु. .२/२५,२६ अ.ह्रु.उ ३५/३३ अ.सां.उ ४०/२४) 
सर्वमशनतगुरुष्र्णतीक्ष्र्णम ्दन्कुारुर्णाश्च चेष््ााः.... न थक्तानन 
र्वसाांभस त्रबिृयारोन मदन्कु थाणर्ण मध्यारोयभ्यर्वहथेरोन 
......परथर्वजयशेत|्| 
(च.शा ४/१८) 
Effect of augmenting cumulative toxicity on 
11/27/2014 16 
progeny
The Diseases caused due to विरुद्दाहार:- 
षार्णढयारोध्यवर्वसपशदन्कु ादन्कुथार्णाां वर्वस्फा् ारोमादन्कु 
िगरोदन्कुथार्णाां | 
मूर्ाशमदन्कुाध्मानगलग्रहार्णाां 
पाण्ड्र्वामयस्यामवर्वषस्य चैर्व || 
क लास ुष््ग्रहर्णीगदन्कुानाां 
शा ाम्लवपत्तज्र्वथपीनसानाां | 
सांतानदन्कुाषस्य त ैर्व मृत्यावर्वशरुद्दन्कुमरोनां 
प्रर्वदन्कुग्रोत हेतुम ्|| 
(च.सू.२६/१०२-१०३) 
Effect of augmenting cumulative toxicity on 
11/27/2014 17 
progeny
सहज व्याधि 
Effect of augmenting cumulative toxicity on 
11/27/2014 18 
progeny
Management 
Nidana 
parivarjana 
Dooshivisha 
line of 
treatment 
Garbhasthapa 
na oushadhi 
with vishagna 
property 
Agadapana 
with 
garbhasthapa 
na property 
Effect of augmenting cumulative toxicity on 
11/27/2014 19 
progeny
Conclusion 
• It was always assumed that “The fetus is 
isolated in the womb from things in the 
environment." 
• But every exposure either good or bad has 
close relation with a new innocent life …. 
• Let us avoid harmful effects over tiny beautiful 
buds…. 
Effect of augmenting cumulative toxicity on 
11/27/2014 20 
progeny
Effect of augmenting cumulative toxicity on 
11/27/2014 21 
progeny

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Teratogenecity

  • 1. Effect of augmenting cumulative toxicity on 11/27/2014 1 progeny
  • 2. Effect of augmenting cumulative toxicity on progeny By, Dr.Shwetha.K II yr PG Scholar Dept.of Agadatantra SDMCA,Udupi Under the guidance of, Dr.K.Shobha Bhat Associate professor Dept.of Agadatantra SDMCA,Udupi
  • 3. Introduction • To become a mother of a healthy child - most cherished desire of every woman. • She bears the entire responsibility of progeny from conception to the maturity of fetus. Effect of augmenting cumulative toxicity on 11/27/2014 3 progeny
  • 4. • ...ऋतु क्षेत्राम्बुबीजानाां सामाग्र्यादन्कुरो ुथा य ा | (सु.शा.२/३३) Effect of augmenting cumulative toxicity on 11/27/2014 4 progeny
  • 5. • The drastic change in lifestyle and habits of people during present modern era - sufferings from many angles, most alarming being their health & health of their offsprings. Effect of augmenting cumulative toxicity on 11/27/2014 5 progeny
  • 6. • Maternal exposure to different mediums like  alcohol tobacco harmful medications accumulation certain chemicals of environment of toxins the incompatible foods inside the  the high doses of radiation body Effect of augmenting cumulative toxicity on 11/27/2014 6 progeny
  • 7. An estimated 270000 newborns die during the first 28 days of life every year from congenital anomalies. In 2010, 2.7 million neonatal deaths documented in 193 countries. Globally, 10 million infants & children die each year before 5th birthday. Effect of augmenting cumulative toxicity on 11/27/2014 7 progeny
  • 8. Modes of exposure Occupa tional Environm ental Food & drinks Chemical & drugs Metals & minerals Effect of augmenting cumulative toxicity on 11/27/2014 8 progeny
  • 9. Environmental cause Polluted water Polluted air Radiational Effect of augmenting cumulative toxicity on 11/27/2014 9 progeny
  • 10. • Hiroshima & Nagasaki • Minamata syndrome • Endosulfan issue Effect of augmenting cumulative toxicity on 11/27/2014 10 progeny
  • 11. • Mobile phone radiation exposure in the womb can affect the brain development of offspring and potentially lead to neurobehavioral disorders (in mice). (www.nature.com/srep/2012) Effect of augmenting cumulative toxicity on 11/27/2014 11 progeny
  • 12. Eating Habits Junk foods/fast food Carbonated Beverages Incompatible foods Fruits & vegetables Soft drinks - ↑asthma & ↓ bone development (sciencenordic.com) (www.families.com/blog) Junk food – alter brain chemistry as opium & heroine Alter dopamine secretion, ↑tolerance to sugar & fats (http://www.hindustantimes.com) Effect of augmenting cumulative toxicity on 11/27/2014 12 progeny
  • 13. Exposure of mother/father to pesticides before conception or during pregnancy In utero exposure Congenital anomalies fetal death growth retardation eye defects, spontaneous abortion a small-for-gestational age baby limb reduction early childhood cancer low birth weight urogenital defects reduced length hypospadias small head circumference. cryptorchidism orofacial clefts heart defects CNS defects Effect of augmenting cumulative toxicity on (www11./w27/h20o1.4int/ceh) 13 progeny
  • 14. Prenatal exposure→ fetal brain →both structurally & functionally Child suffers from fetal alcohol syndrome Anatomical changes in brain- basal ganglia, corpus callosum, cerebellum and hippocampus Functionally→ deficits in cognitive & behavioral functions, learning & memory Effect of augmenting cumulative toxicity on 11/27/2014 14 (www.niaaa.nih.gov/alcohol-health) progeny
  • 15. Tobacco Prenatal exposure to tobacco Anxiety & depression of Low birth weight, Intrauterine death early childhood Signs of CNS stress Low IQ level More excitable, ↑ muscle tension ( Salihu and Wilson, 2007) (Robinson et al., 2008) (Law et al., 2003) (Fried, 2002; Herrmann, King & Weitzman, 2008) Effect of augmenting cumulative toxicity on 11/27/2014 15 progeny
  • 16. आयुर्वेदन्कुीय वर्वमशश यत्स् ार्वथांजङ्गम ृत्रत्रमांर्वा दन्कुेहादन्कुशेषांयदन्कुननगशतांतत्।जीर्णं वर्वषघ्नौषधिभिहशतांर्वा दन्कुार्वाग्ननर्वातातपशावषतांर्वा ॥स्र्विार्वता र्वा गुर्णवर्वप्रहीनांवर्वषांहह दन्कुूषीवर्वषतामुपैनत ।र्वीयाशल्पपिार्वारोन ननपातयेत्तत् फाव्रुतांर्वषशगर्णानुबग्रोि ॥ (सु. .२/२५,२६ अ.ह्रु.उ ३५/३३ अ.सां.उ ४०/२४) सर्वमशनतगुरुष्र्णतीक्ष्र्णम ्दन्कुारुर्णाश्च चेष््ााः.... न थक्तानन र्वसाांभस त्रबिृयारोन मदन्कु थाणर्ण मध्यारोयभ्यर्वहथेरोन ......परथर्वजयशेत|्| (च.शा ४/१८) Effect of augmenting cumulative toxicity on 11/27/2014 16 progeny
  • 17. The Diseases caused due to विरुद्दाहार:- षार्णढयारोध्यवर्वसपशदन्कु ादन्कुथार्णाां वर्वस्फा् ारोमादन्कु िगरोदन्कुथार्णाां | मूर्ाशमदन्कुाध्मानगलग्रहार्णाां पाण्ड्र्वामयस्यामवर्वषस्य चैर्व || क लास ुष््ग्रहर्णीगदन्कुानाां शा ाम्लवपत्तज्र्वथपीनसानाां | सांतानदन्कुाषस्य त ैर्व मृत्यावर्वशरुद्दन्कुमरोनां प्रर्वदन्कुग्रोत हेतुम ्|| (च.सू.२६/१०२-१०३) Effect of augmenting cumulative toxicity on 11/27/2014 17 progeny
  • 18. सहज व्याधि Effect of augmenting cumulative toxicity on 11/27/2014 18 progeny
  • 19. Management Nidana parivarjana Dooshivisha line of treatment Garbhasthapa na oushadhi with vishagna property Agadapana with garbhasthapa na property Effect of augmenting cumulative toxicity on 11/27/2014 19 progeny
  • 20. Conclusion • It was always assumed that “The fetus is isolated in the womb from things in the environment." • But every exposure either good or bad has close relation with a new innocent life …. • Let us avoid harmful effects over tiny beautiful buds…. Effect of augmenting cumulative toxicity on 11/27/2014 20 progeny
  • 21. Effect of augmenting cumulative toxicity on 11/27/2014 21 progeny