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ASCITES
BY
DR.P.B.SADIQ_ULL
A
WHAT ISASCITES?
 Greek origin (askos)
and means bag or sac
 It is the collection of
fluid in the peritoneal
cavity
 Syn:-
Hydroperitoneum
 Hydraskos or
abdominal dropsy
UNANI CONCEPT
‫اء‬‫استسق‬:-‫ک‬‫ے‬‫پی‬ ‫معنی‬ ‫لفظی‬‫ٹ‬‫می‬‫ں‬‫مائل‬ ‫زردی‬
‫جمع‬‫پانی‬‫ہ‬‫وجان‬‫ے‬‫ک‬‫ے‬‫ہ‬‫ی‬‫ں۔‬‫طور‬ ‫اصطالحی‬‫لیکین‬
‫س‬ ‫عروق‬ ‫جب‬‫پر‬‫ے‬‫الدم‬‫مصل‬ ‫یعنی‬ ‫مائیت‬ ‫کی‬ ‫خون‬
‫مترشح‬‫ہ‬‫ک‬ ‫مخاطی‬ ‫غشاء‬ ‫یا‬ ‫جلد‬‫وکر‬‫ے‬‫نیچ‬‫ے‬‫خالؤ‬‫ں‬
‫رخنو‬ ‫اور‬‫ں‬‫می‬‫ں‬‫می‬ ‫جوف‬‫کسی‬ ‫یا‬‫ں‬‫جمع‬‫ہ‬‫وجاتی‬‫ہے‬
‫اس‬‫تو‬‫ے‬‫ک‬ ‫اء‬‫استسق‬‫ہ‬‫اجاتا‬‫ہے۔‬
‫سبب‬:-‫ماد‬‫ہ‬‫بارد‬‫ہ‬‫غریب‬‫ہ‬‫ہ‬‫وتا‬‫ہے۔‬
‫اقسام‬:-
(Abdominal ascites) ‫زقی‬ ‫اء‬‫استسق‬-‫رجرج‬‫ہ‬
(Anasarca)‫لحمی‬ ‫اء‬‫استسق‬
ASCITES
It is pathological collection of fluid in the peritoneal cavity.
In Western countries cirrhosis is the commonest cause (80%) of
ascites. Ascites is the most common complication of cirrhosis. It
is a poor prognostic factor. Portal hypertension, renin angiotensin
aldosterone pathway causing renal sodium retention, increased
hydrostatic pressure in hepatic sinusoids and splanchnic vessels
cause ascites. In metastatic malignancy ascites develops due to
liver secondaries, peritoneal carcinomatosis which secretes protein
rich fluid and lymph. Leakage of pancreatic juice, bile, lymph also
causes specific ascites
Clinical Types
Mild — 0 to 150 ml amount required to
demonstrate radiologically
Moderate — 500–2000 ml causes clinical dullness
in flanks.
Severe — > 2000 ml.
TWO GRADING SYSTEMS FOR ASCITES
HAVE BEEN USED IN THE LITERATURE.
An old system which grades ascites from 1+
to 4+, depending on the detectability of fluid
on physical examination.
More recently, the International Ascites Club
has proposed a system of grading from 1 to 3.
The older system
1+ is minimal and barely detectable.
2+ is moderate.
3+ is massive but not tense.
4+ is massive and tense.
The International Ascites Club grading (2003)
Grade 1: mild ascites detectable only by US.
Grade 2: moderate ascites manifested by
moderate symmetrical abdominal distension.
Grade 3: large or gross ascites with marked
abdominal distension.
Etiological Classification
Transudate
(Protein < 2.5 g/dl).
CCF—Commonest
(SAAG >1.1).
Hypoproteinaemia.
Anaemia.
Beri-beri.
Nephrotic syndrome.
Portal hypertension.
Polyserositis.
Exudate (Protein >2.5 g/dl)
(SAAG <1.1).
Peritoneal diseases.
Tuberculosis.
Bacterial, fungal and
parasitic infection.
Neoplasm.
Collagen disorder.
Eosinophilic gastroenteritis.
Granulomatous peritonitis.
NONPERITONEAL
CAUSES OF ASCITES
Non-peritoneal causes
Intrahepatic portal
hypertension
Extrahepatic portal
hypertension
Hypoalbuminemia
Examples
Cirrhosis
Fulminant hepatic failure
Veno-occlusive disease
Hepatic vein obstruction
(ie, Budd-Chiari syndrome)
Congestive heart failure
Nephrotic syndrome
Protein-losing enteropathy
Malnutrition
Miscellaneous disorders Myxedema
Ovarian tumors
Pancreatic & Biliary ascites
Chylous Secondary to malignancy, trauma
PERITONEAL CAUSES OF
ASCITES
Peritoneal Causes Examples
Malignant ascites Primary peritoneal mesothelioma
Secondary peritoneal
carcinomatosis
Granulomatous peritonitis Tuberculous peritonitis
Fungal and parasitic infections
Sarcoidosis
Foreign bodies (cotton ,starch,
barium)
Vasculitis
Miscellaneous disorders
Systemic lupus erythematosus
Henoch-Schönlein purpura
Eosinophilic gastroenteritis
Whipple disease
Endometriosis
PATHOPHYSIOLOGY
Portal hypertension, renin angiotensin
aldosterone pathway causing
renal sodium retention,
increased hydrostatic pressure in hepatic
sinusoids and splanchnic vessels causes
ascites.
Underfill theory
Overflow theory
Lymph imbalance
theory
Vasodilation theory
UNDERFILLING
Primary
• Liver damage
• Portal hypertension sends salt retaining signal
• Retention of Sodium
• Volume expansion
• Overflow from Intravascular volume
• Ascites formation
PERIPHERAL ARTERIAL
VASODILATION
Contradicts “classical” theories
Extravasation from
intravascular space
(Lymph Production)
Reflux into vascular
system (Lymphatic
Drainage)
PORTAL
HYPERTENSION
Vasodilatation, Decrease Splanchnic
Systemic vascular resistance
Reduction in arterial blood volume
Activation of neurohumoral pressor systems
Renal sodium & water retention
Clinical Features
Symptoms
Gradual distention of abdomen
Severe cases of ascites may lead to
respiratory embarrassment.
Specific features related to the cause may
be evident.
Signs
Mild:
Puddle sign—Tapping around the umbilicus in knee-elbow position elicits
dullness.
Moderate:
Positive shifting dullness in the abdomen.
Severe:
Positive fluid thrill.
Tanyol sign: Umbilicus is shifted upward in pelvic mass (ovarian
cyst) downwards in ascites.
Hamilton ruler test is also used to differentiate ascites from ovarian
cyst. This Blaxland (Athelstan Blaxland) ruler test shows pulsation
in ovarian cyst not in ascites. A flat ruler is placed on the abdomen
just above the anterior superior iliac spines and pressed firmly backwards. If the
swelling is due to ovarian cyst, transmitted aortic pulsation can be felt across the
ruler.
Smiling horizontal umbilicus.
DIAGNOSIS
Investigations
* Ultrasound abdomen.
* Ascitic tap—always should be done after emptying
the bladder by placing the needle
below the umbilicus lateral to the
rectus muscle. It may be Diagnostic or
Therapeutic tap. Fluid is sent for
analysis.
Ascitic fluid having cells less than 1000/mm3 is clear;
from 1000–5000/mm3 is unclear;
more than 5000/mm3 is turbid/cloudy.
(trauma during tapping) blood will clot.
Lipid in the ascitic fluid is seen in chylous ascites.
In cirrhotic patients, ascitic fluid without SBP contains less
than 500 cells/mm3 with 50% of them are neutrophils. If ascitic
fluid contains more than 250 neutrophils/mm3 it suggests acute
inflammation.
Serum ascites albumin gradient (SAAG) is calculated by
subtracting ascitic fluid albumin level from serum albumin level.
If SAAG more than 1.1, it is called as high gradient
which suggests portal hypertension. If SAAG is less than 1.1,
it is called as low gradient which suggests absence of portal
hypertension. SAAG is 98% accurate.
High gradient SAAG is seen in—cirrhosis, alcoholic,
cardiac ascites, multiple liver secondaries, fulminant liver
failure, Budd-Chiari syndrome, portal vein thrombosis.
Low gradient SAAG is seen in—peritoneal secondaries,
peritoneal tuberculosis, pancreatic ascites, biliary ascites,
nephrotic syndrome, lymph leak, connective tissue diseases
causing ascites.
Abdominal fluid
Straw coloured fluid
Cirrhosis
Tuberculosis
Hypoproteinaemia
Nephrotic syndrome
Budd-Chiari syndrome (Hepatic vein
thrombosis)
Constrictive pericarditis
Chronic pancreatitis
Ovarian tumour (Meig’s syndrome)
Malignancy
Haemorrhagic fluid
Traumatic tap
Tumour
Acute haemorrhagic pancreatitis
Bleeding disorder
Chylous fluid
Parasitic infestation—filariasis
Tuberculosis
Malignancy of thoracic duct
Trauma to thoracic duct
Thrombosis of subclavian vein
Purulent fluid
Abdominal infections
Penetrating wounds or infections
Pyaemia and septicaemia ,Rupture/perforation of an organ
Treatment
The cause is treated.
Therapeutic tap—It should be slow and gradual or
staged tapping. Up to 5 liters can
be tapped in 90 minutes.
Complications of ascites
Respiratory embarrassment
Umbilical hernia with erosion, ulceration and leak
Spontaneous bacterial peritonitis
UNANI MANAGEMENT OF ASCITES
‫غذا‬ ‫بال‬ ‫عالج‬
‫دویہ‬ ‫بال‬ ‫عالج‬
‫تدبیر‬ ‫بل‬ ‫عالج‬
1‫کرے۔‬ ‫ازالہ‬ ‫کا‬ ‫سبب‬
2‫کرے۔‬ ‫استعمال‬ ‫کا‬ ‫مدرات‬
3‫کرے۔‬ ‫استعمال‬ ‫کا‬ ‫کبد‬ ‫موقوی‬
4‫سورت‬ ‫کی‬ ‫ہونے‬ ‫معلوم‬ ‫نہ‬ ‫سبب‬
‫شکم‬ ‫خلل‬ ‫نسخیہ‬ ‫میں‬
• Bed rest
• Diet
• Diuretics
• Fluid Restriction
• Paracentesis
• TIPSS
• Shunts
• Transplant
TREATMENT
OPTIONS
 Salt restriction
 Diuretics
1. Spironolactone
(Aldactone)
2. Furosemide
(Lasix)
3. Amiloride
(Midamor)
4. Mannitol
(Osmitrol)
 Paracentesis
 transjugular
intrahepatic
portosystem
ic shunt
(TIPS)
 Liver transplant
Ascites by dr. p.b.sadiq_ulla

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Ascites by dr. p.b.sadiq_ulla

  • 2. WHAT ISASCITES?  Greek origin (askos) and means bag or sac  It is the collection of fluid in the peritoneal cavity  Syn:- Hydroperitoneum  Hydraskos or abdominal dropsy
  • 3. UNANI CONCEPT ‫اء‬‫استسق‬:-‫ک‬‫ے‬‫پی‬ ‫معنی‬ ‫لفظی‬‫ٹ‬‫می‬‫ں‬‫مائل‬ ‫زردی‬ ‫جمع‬‫پانی‬‫ہ‬‫وجان‬‫ے‬‫ک‬‫ے‬‫ہ‬‫ی‬‫ں۔‬‫طور‬ ‫اصطالحی‬‫لیکین‬ ‫س‬ ‫عروق‬ ‫جب‬‫پر‬‫ے‬‫الدم‬‫مصل‬ ‫یعنی‬ ‫مائیت‬ ‫کی‬ ‫خون‬ ‫مترشح‬‫ہ‬‫ک‬ ‫مخاطی‬ ‫غشاء‬ ‫یا‬ ‫جلد‬‫وکر‬‫ے‬‫نیچ‬‫ے‬‫خالؤ‬‫ں‬ ‫رخنو‬ ‫اور‬‫ں‬‫می‬‫ں‬‫می‬ ‫جوف‬‫کسی‬ ‫یا‬‫ں‬‫جمع‬‫ہ‬‫وجاتی‬‫ہے‬ ‫اس‬‫تو‬‫ے‬‫ک‬ ‫اء‬‫استسق‬‫ہ‬‫اجاتا‬‫ہے۔‬ ‫سبب‬:-‫ماد‬‫ہ‬‫بارد‬‫ہ‬‫غریب‬‫ہ‬‫ہ‬‫وتا‬‫ہے۔‬ ‫اقسام‬:- (Abdominal ascites) ‫زقی‬ ‫اء‬‫استسق‬-‫رجرج‬‫ہ‬ (Anasarca)‫لحمی‬ ‫اء‬‫استسق‬
  • 4. ASCITES It is pathological collection of fluid in the peritoneal cavity. In Western countries cirrhosis is the commonest cause (80%) of ascites. Ascites is the most common complication of cirrhosis. It is a poor prognostic factor. Portal hypertension, renin angiotensin aldosterone pathway causing renal sodium retention, increased hydrostatic pressure in hepatic sinusoids and splanchnic vessels cause ascites. In metastatic malignancy ascites develops due to liver secondaries, peritoneal carcinomatosis which secretes protein rich fluid and lymph. Leakage of pancreatic juice, bile, lymph also causes specific ascites
  • 5. Clinical Types Mild — 0 to 150 ml amount required to demonstrate radiologically Moderate — 500–2000 ml causes clinical dullness in flanks. Severe — > 2000 ml.
  • 6. TWO GRADING SYSTEMS FOR ASCITES HAVE BEEN USED IN THE LITERATURE. An old system which grades ascites from 1+ to 4+, depending on the detectability of fluid on physical examination. More recently, the International Ascites Club has proposed a system of grading from 1 to 3.
  • 7. The older system 1+ is minimal and barely detectable. 2+ is moderate. 3+ is massive but not tense. 4+ is massive and tense. The International Ascites Club grading (2003) Grade 1: mild ascites detectable only by US. Grade 2: moderate ascites manifested by moderate symmetrical abdominal distension. Grade 3: large or gross ascites with marked abdominal distension.
  • 8.
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  • 11. Etiological Classification Transudate (Protein < 2.5 g/dl). CCF—Commonest (SAAG >1.1). Hypoproteinaemia. Anaemia. Beri-beri. Nephrotic syndrome. Portal hypertension. Polyserositis. Exudate (Protein >2.5 g/dl) (SAAG <1.1). Peritoneal diseases. Tuberculosis. Bacterial, fungal and parasitic infection. Neoplasm. Collagen disorder. Eosinophilic gastroenteritis. Granulomatous peritonitis.
  • 12. NONPERITONEAL CAUSES OF ASCITES Non-peritoneal causes Intrahepatic portal hypertension Extrahepatic portal hypertension Hypoalbuminemia Examples Cirrhosis Fulminant hepatic failure Veno-occlusive disease Hepatic vein obstruction (ie, Budd-Chiari syndrome) Congestive heart failure Nephrotic syndrome Protein-losing enteropathy Malnutrition Miscellaneous disorders Myxedema Ovarian tumors Pancreatic & Biliary ascites Chylous Secondary to malignancy, trauma
  • 13. PERITONEAL CAUSES OF ASCITES Peritoneal Causes Examples Malignant ascites Primary peritoneal mesothelioma Secondary peritoneal carcinomatosis Granulomatous peritonitis Tuberculous peritonitis Fungal and parasitic infections Sarcoidosis Foreign bodies (cotton ,starch, barium) Vasculitis Miscellaneous disorders Systemic lupus erythematosus Henoch-Schönlein purpura Eosinophilic gastroenteritis Whipple disease Endometriosis
  • 15. Portal hypertension, renin angiotensin aldosterone pathway causing renal sodium retention, increased hydrostatic pressure in hepatic sinusoids and splanchnic vessels causes ascites.
  • 16.
  • 17. Underfill theory Overflow theory Lymph imbalance theory Vasodilation theory
  • 18.
  • 20. Primary • Liver damage • Portal hypertension sends salt retaining signal • Retention of Sodium • Volume expansion • Overflow from Intravascular volume • Ascites formation
  • 22. Contradicts “classical” theories Extravasation from intravascular space (Lymph Production) Reflux into vascular system (Lymphatic Drainage)
  • 23. PORTAL HYPERTENSION Vasodilatation, Decrease Splanchnic Systemic vascular resistance Reduction in arterial blood volume Activation of neurohumoral pressor systems Renal sodium & water retention
  • 24.
  • 25. Clinical Features Symptoms Gradual distention of abdomen Severe cases of ascites may lead to respiratory embarrassment. Specific features related to the cause may be evident.
  • 26. Signs Mild: Puddle sign—Tapping around the umbilicus in knee-elbow position elicits dullness. Moderate: Positive shifting dullness in the abdomen. Severe: Positive fluid thrill. Tanyol sign: Umbilicus is shifted upward in pelvic mass (ovarian cyst) downwards in ascites. Hamilton ruler test is also used to differentiate ascites from ovarian cyst. This Blaxland (Athelstan Blaxland) ruler test shows pulsation in ovarian cyst not in ascites. A flat ruler is placed on the abdomen just above the anterior superior iliac spines and pressed firmly backwards. If the swelling is due to ovarian cyst, transmitted aortic pulsation can be felt across the ruler. Smiling horizontal umbilicus.
  • 28. Investigations * Ultrasound abdomen. * Ascitic tap—always should be done after emptying the bladder by placing the needle below the umbilicus lateral to the rectus muscle. It may be Diagnostic or Therapeutic tap. Fluid is sent for analysis.
  • 29. Ascitic fluid having cells less than 1000/mm3 is clear; from 1000–5000/mm3 is unclear; more than 5000/mm3 is turbid/cloudy. (trauma during tapping) blood will clot. Lipid in the ascitic fluid is seen in chylous ascites. In cirrhotic patients, ascitic fluid without SBP contains less than 500 cells/mm3 with 50% of them are neutrophils. If ascitic fluid contains more than 250 neutrophils/mm3 it suggests acute inflammation. Serum ascites albumin gradient (SAAG) is calculated by subtracting ascitic fluid albumin level from serum albumin level.
  • 30. If SAAG more than 1.1, it is called as high gradient which suggests portal hypertension. If SAAG is less than 1.1, it is called as low gradient which suggests absence of portal hypertension. SAAG is 98% accurate. High gradient SAAG is seen in—cirrhosis, alcoholic, cardiac ascites, multiple liver secondaries, fulminant liver failure, Budd-Chiari syndrome, portal vein thrombosis. Low gradient SAAG is seen in—peritoneal secondaries, peritoneal tuberculosis, pancreatic ascites, biliary ascites, nephrotic syndrome, lymph leak, connective tissue diseases causing ascites.
  • 31. Abdominal fluid Straw coloured fluid Cirrhosis Tuberculosis Hypoproteinaemia Nephrotic syndrome Budd-Chiari syndrome (Hepatic vein thrombosis) Constrictive pericarditis Chronic pancreatitis Ovarian tumour (Meig’s syndrome) Malignancy Haemorrhagic fluid Traumatic tap Tumour Acute haemorrhagic pancreatitis Bleeding disorder Chylous fluid Parasitic infestation—filariasis Tuberculosis Malignancy of thoracic duct Trauma to thoracic duct Thrombosis of subclavian vein Purulent fluid Abdominal infections Penetrating wounds or infections Pyaemia and septicaemia ,Rupture/perforation of an organ
  • 32. Treatment The cause is treated. Therapeutic tap—It should be slow and gradual or staged tapping. Up to 5 liters can be tapped in 90 minutes.
  • 33. Complications of ascites Respiratory embarrassment Umbilical hernia with erosion, ulceration and leak Spontaneous bacterial peritonitis
  • 34. UNANI MANAGEMENT OF ASCITES ‫غذا‬ ‫بال‬ ‫عالج‬ ‫دویہ‬ ‫بال‬ ‫عالج‬ ‫تدبیر‬ ‫بل‬ ‫عالج‬
  • 35. 1‫کرے۔‬ ‫ازالہ‬ ‫کا‬ ‫سبب‬ 2‫کرے۔‬ ‫استعمال‬ ‫کا‬ ‫مدرات‬ 3‫کرے۔‬ ‫استعمال‬ ‫کا‬ ‫کبد‬ ‫موقوی‬ 4‫سورت‬ ‫کی‬ ‫ہونے‬ ‫معلوم‬ ‫نہ‬ ‫سبب‬ ‫شکم‬ ‫خلل‬ ‫نسخیہ‬ ‫میں‬
  • 36. • Bed rest • Diet • Diuretics • Fluid Restriction • Paracentesis • TIPSS • Shunts • Transplant TREATMENT OPTIONS
  • 37.  Salt restriction  Diuretics 1. Spironolactone (Aldactone) 2. Furosemide (Lasix) 3. Amiloride (Midamor) 4. Mannitol (Osmitrol)
  • 40.