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Q:1 Painless loss of vision is seen in all, EXCEPT:
A: Papilledema
B: Papillitis
C: Angle closure glaucoma
D: CRAO
Correct Ans:C
Explanation
Acute angle­closure glaucoma is an ophthalmic emergency that
causes severe visual loss without treatment. Symptoms include
ocular pain, blurred vision, lacrimation, halos around lights,
frontal headache, nausea, and vomiting.
Causes of Sudden Painless Loss of Vision:
1.  Retinal detachment
2.  Vitreous haemorrhage
3.  Retinal vein occlusion
4.  Retinal artery occlusion
5.  Wet age related macular degeneration
6.  Anterior ischemic optic neuropathy
7.  Optic neuritis
8.  Cerebrovascular accident
9.  Papillitis
10.  Papilledema
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Q:2 Sudden loss of vision is seen in following, except:
A: CRAO
B: CRVO
C: Optic neuritis
D: Papilledema
Correct Ans:D
Explanation
Papilledema (choked disk) is usually a symptom of increased intracranial pressure
caused by a mass, such as a brain tumor. The increased pressure is transmitted to the
optic disk through the extension of the subarachnoid space around the optic nerve.
Papilledema caused by a sudden increase in intracranial pressure develops within 24 to
48 hours. Visual acuity is not affected in papilledema, although the blind spot may be
enlarged.
 
Ref :Chang D.F. (2011). Chapter 2. Ophthalmologic Examination. In P. Riordan­Eva,
E.T. Cunningham, Jr. (Eds), Vaughan & Asbury's General Ophthalmology, 18e.
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Q:3 Fundus examination of a patient presenting with loss of vision revealed a Cherry 
red spot on the macula. What is he most likely suffering from?
A: Retinitis pigmentosa
B: Retinoblastoma
C: CRAO
D: CRVO
Correct Ans:C
Explanation
Cherry red spot on the retina is seen in central retinal artery occlusion. Other retinal signs in this 
condition includes retinal oedema and segmentation of blood column in the retinal vein (cattle 
tracking sign). Patients often presents with sudden painless loss of vision.
Reference:
Comprehensive Ophthalmology By A K Khurana, 4th Edition, Page
255.
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Q:4 Which of the following condition is associated with Macular edema?
A: CRAO
B: Papilledema
C: Diabetes mellitus
D: Age related macular degeneration
Correct Ans:C
Explanation
Cystoid macular edema occur following retinal vascular disorders such as diabetic
retinopathy caused by diabetes mellitus and central retinal vein occlusion. It can also
occur as a post operative complication following cataract extraction and penetrating
keratoplasty, following intraocluar inflammation, as a side effect of adrenaline eyedrops
and in retinal dystrophies.
Must know:
Cystoid macular edema:
It refers to collection of fluid in the outer plexiform layer (Henle’s layer) and
inner nuclear layer of the retina centred around the foveola.
It occur due to leakage of fluid following breakdown of inner blood retinal barrier.
Ophthalmoscopy in this case shows honey comb appearence.
Fundus fluorescein angiography shows flower petal appearence.
 
Ref: Comprehensive Ophthalmology By AK Khurana, 4th edn, page 273
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Q:5 Rubeosis iridis is NOT COMMONLY seen in:
A: CRVO
B: CRAO
C: Diabetic retinopathy
D: Neovascularization
Correct Ans:B
Explanation
Rubeosis iridis or neovascularization of iris is a medical condition of the iris in which
new blood vessels are found on the surface of the iris. It is associated with conditions
which cause ischemia of the retina. Conditions commonly associated with rubeosis
iridis are central retinal vein occlusion, proliferative diabetic retinopathy, ocular
ischemic syndrome, ocular surgery complication and chronic retinal detachment.
Rubeosis iridis may also be associated with CRAO but is less common than with CRVO.
 
Ischemic diseases of the retina causes the release of VEGF which in turn stimulate
angiogenesis. They can be seen on the iris, and it can also grow into the angle of the
eye resulting in an increase in intra ocular pressure.
 
Ref: Glaucoma Surgery  edited by Ashok Garg, page 350, Ocular Angiogenesis:
Diseases, Mechanisms, and Therapeutics  edited by Joyce Tombrain­Tink, PAGE 128.
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Q:6 Cherry red spot is seen in all of the following conditions, EXCEPT:
A: CRAO
B: Tay Sach’s disease
C: Niemman pick’s disease
D: Central retinal vein occlusion
Correct Ans:D
Explanation
Cherry red spots of the macula are produced when ganglion cells filled with lipid
degenerate thereby exposing the vascular choroidal tissue behind these cells. Central
retinal vein occlusion is not associated with cherry red spot. In CRVO retina appears
congested with large areas of flame hemorrhages.
 
Conditions associated with cherry red spot:
Central retinal artery occlusion
Tay sachs disease
Farber’s disease
Sandhoff’s disease
Neimann Pick disease
Goldberg’s syndrome
Gaucher’s disease
Gangliosidase GM1 type 2
Hurler’s syndrome
Ref: Ophthalmology  edited by Myron Yanoff, 3rd edn page 590
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Q:7 Clinical examination of a patient shows ring scotoma. It is seen in the following
condition:
A: Papilloedema
B: Macular edema
C: CRAO
D: Retinitis pigmentosa
Correct Ans:D
Explanation
Annular or ring­shaped scotoma is a typical feature of retinitis pigmentosa which
corresponds to the degenerated equatorial zone of retina. As the disease progresses,
scotoma increases anteriorly and posteriorly and ultimately only central vision is left
(tubular vision). Eventually even this is also lost and the patient becomes blind.
 
Ref: Comprehensive Ophthalmology by AK Khurana, 4th edition, Page 268­269.
 
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Q:8
A female presented with progressive loss of vision during night since few months.
Fundoscopy shows "bone­spicule formation". Her two brothers and mother are
also suffering with the same problem. Diagnosis is:
A: Papilledema
B: Macular edema
C: CRAO
D: Retinitis pigmentosa
Correct Ans:D
Explanation
Retinitis pigmentosa is a group of heterogeneous hereditary retinal degenerations
characterized by progressive dysfunction of the photoreceptors, associated with
progressive cell loss and eventual atrophy of several retinal layers. Inheritance of the
typical form can be autosomal recessive, autosomal dominant, or X­linked recessive.
The hallmark symptoms of retinitis pigmentosa are night
blindness (nyctalopia) and gradually progressive peripheral
visual field loss as a result of increasing and coalescing ring
scotomas. The most characteristic fundoscopic findings are
attenuated retinal arterioles, waxy pale optic disk, mottling of
the retinal pigment epithelium, and peripheral retinal pigment
clumping, referred to as "bone­spicule formation".
 
Ref: Fletcher E.C., Chong N., Augsburger J.J., Corrêa Z.M. (2011). Chapter 10. Retina.
In P. Riordan­Eva, E.T. Cunningham, Jr. (Eds), Vaughan & Asbury's General
Ophthalmology, 18e.
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Q:9 Cattle track appearance in fundoscopy is due to?
A: CRAO
B: CRVO
C: Retinitis pigmentosa
D: Diabetic retinopathy
Correct Ans:A
Explanation
 
CRAO REF: Elsevier Comprehensive Guide, page 628 Common fundoscopy findings:
Condition Finding
Optic disc coloboma Morning glory appearance
CRAO Cattle track appearance
CRVO Blood and thunder fundus
Chloroquine toxicity Bull's eye maculopathy
Quinine toxicity Cherry red spot
Retinitis pigmentosa Waxy pallor of optic disc
Bone spicule pigmentation
Congenital syphilis/ Rubella Salt and pepper fundus
Sickle cell anemia Rising sun sign
CMV retinitis Mozzarella pizza fundus
AIDS Cotton wool spots
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Q:10 Cattle track appearance in fundoscopy is due to?
A: CRAO
B: CRVO
C: Retinitis pigmentosa
D: Diabetic retinopathy
Correct Ans:A
Explanation
 
CRAO REF: Elsevier Comprehensive Guide, page 628 Common fundoscopy findings:
Condition Finding
Optic disc coloboma Morning glory appearance
CRAO Cattle track appearance
CRVO Blood and thunder fundus
Chloroquine toxicity Bull's eye maculopathy
Quinine toxicity Cherry red spot
Retinitis pigmentosa Waxy pallor of optic disc
Bone spicule pigmentation
Congenital syphilis/ Rubella Salt and pepper fundus
Sickle cell anemia Rising sun sign
CMV retinitis Mozzarella pizza fundus
AIDS Cotton wool spots
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Q:11 Which of the following is not an ophthalmic emergency? 
A: Macular hole
B: Retinal detachment
C: CRAO
D: Acute primary angle closure glaucoma
Correct Ans:A
Explanation
Macular hole REF: Yanoff Ophthalmology 2nd edition
"A Macular hole is a break in the central part of the retina (macula), causing blurred
and distorted vision. While this can occur after trauma, it usually presents
spontaneously. The treatment of macular hole involves surgery. While the repair of a
macular hole is not an emergency there is a general consensus that repair should occur
within 6­12 months after onset to maximize visual recovery"
"Eye injury, retinal detachment, and central retinal artery occlusion (CRAO) are
among the most common ocular emergencies"
Following are ocular emergencies:
1.  Acute infectious endophthalmitis
2.  Acute primary angle­closure glaucoma
3.  Infectious keratitis
4.  Orbital hemorrhage
5.  Retinal detachment
6.  Foreign body
7.  Orbital fractures
8.  Corneal abrasions, lacerations, ulcers
9.  Chemical burns 
10.  Ruptured globe
11.  CRAO
12.  Retrobulbar hematoma
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Q:12 Roth's spot is seen in? 
A: Infective endocarditis 
B: Typhoid
C: CRAO
D: Rheumatic carditis
Correct Ans:A
Explanation
Infective endocarditis REF: Harrison's Principles of Internal Medicine 17th ed­
chapter 118
"Roth spots are flame shaped hemorrhages with central cotton wool spots. They are
caused by immune complex deposition and are seen in subacute bacterial
endocarditis"
"In the case of leukemia, the Roth spot is composed of a hemorrhage with a central
aggregation of white blood cells"
Feature of infective endocarditis:
Fever Chills and sweats
Anorexia, Weight loss, Malaise, Myalgias, arthralgias, Back pain
Heart murmur, New/worsened regurgitant murmur
Arterial emboli
Splenomegaly
Clubbing
Peripheral manifestations (Osler's nodes, subungual hemorrhages, Janeway
lesions, Roth's spots)
Petechiae
Laboratory manifestations: Anemia, Leukocytosis, Microscopic hematuria,
Elevated erythrocyte sedimentation rate >90, Elevated C­reactive protein level
>90, Rheumatoid factor, Circulating immune complexes, Decreased serum
complement
Causes of Roth spots:
Subacute bacterial endocarditis
Acute leukemia
Pernicious anemia
Scurvy
CO poisoning
Post cardiac bypass surgery
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Q:13 Painless loss of vision is seen in all except:
A: Pappilodema
B: Pappilitis
C: CRAO
D: Angle closure glaucoma 
Correct Ans:D
Explanation
Angle closure glaucoma 
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