6. 158 等 霖明蔡 傳信胡 Taiwan J Ophthalmol 2009. Vol 48. No 2
症裂分神精對前目，言而度角學理病與化生就而 作合法無全完除排已中驗實本在但，果結響影而低偏
泌分 胺巴多的內體是為認遍普，因病致的 (dopamine) 驗實本而。差不該應度信可其，圍範究研入進患病的
緣邊的腦大其者患症裂分神精為認者學有。起引多過 患 病症裂 分神精 料照在 員人 護醫後 日對果 結有所 的
因，多過胺巴多的生產所域區等
(limbic system) 統系 。的益助所有是該應，時
卻來後是但。狀症性陽等覺幻或聽、狀症想妄生產而
者 患症裂 分神精 釋解全 完法 無怕恐 論理此 憑光現 發 結 論
質皮前葉額的患病出提再者學分部是於，狀症有所的
數胺巴多的生產所域區等
(prefrontal cortical region ) 指告報究研期長的後預者患症裂分神精關有
退活生、淡平感情如例，狀症性陰生產會也，少過量 人病的 ，復康轉好會情病其者患的 至 ：出
1/4 1/3 1/3
多，等 如物藥病神精抗的前目。等縮 chlopromazine 精性慢現呈續繼會者患餘其，狀症床臨的度輕持維將
經神在即用作理藥其，物藥類
Phenorpromazine 於屬 病要需，病疾性慢種一於屬症裂分神精。態狀的病神
受感被不，胺巴多的出釋梢末經神導傳由礙阻中隙間 精示顯果結的驗實本。料照的期長員人護醫與屬家患
狀症的者患輕減以可而進，受接所體受接的梢末經神 偏齡年、性男且而，差為人常正比感體立其者裂分神
或 但。 等 症想妄除 去與覺 幻除減、 礙障考思 如 (2,2829) 其者裂分神精論推們我。顯明為更患病的中院住與高
統系外體錐及睡昏生產會都少或多 (extrapyramidal
在師醫，人常正如不多大感體立的置位間空體物析解
協動運、礙障節調肉肌如例，礙障動運
system; EPS)
發其免避以，題問此視重真認須必也時患病類此顧照
藥的效有與夠足予給期性急在。等能不坐靜與良不調 。件事等傷外生衍或倒跌慎不生
期長應亦後善改見稍情病在而；情病制控以可將，量 參考文獻
典非的少較用作副來年近。發復內間時短免以，用使
，現出的 物藥病神精抗物藥型
(atypical antipschotics) 1. Goldman-Rakic PS. Working memory dysfunction
前向邁更碑程里的療治病疾得使，等
clozapine 如例 in schizophrenia. J Neuropsychiatry Clin Neurosci
較用作副統系外體錐的物藥類此下之較相為因。步一 1994; 6:348-57.
減著顯也象現等症動異性發遲與硬僵肢四、抖顫，少 2. Weinberger DR, Gallhofer B. Cognitive function in
但，物藥選首的者症裂分神精療治為成已來年近，少 schizophrenia. Int Clin Psychopharmacol 1997;
。量的胺巴多的內體低降在是仍也用作理藥其 12(suppl 4): S26-36.
3. Westheimer G. Seeing depth with two eyes:
症亂錯神精的顯明現出旦一患病症裂分神精 stereopsis: Proc R SOC London 1994; 257:205-14.
應均，等為行性擊攻的性發突與覺幻、想妄如例，狀 4. Chen Y, Levy DL, Nakayama K, Mattysse S, Palafox
藥的量大較與多較予給將般一時院住。療治院住即立 GP, Holzmah PS. Dependence of impaired eye tra-
告報曾
( ， 劑制抑成生胺巴多為多 物 ) Bodis-Wollner(30)
cking on deficient velocity discrimination in schizo-
由是都轉機病致的症裂分神精和其 人病的症森金帕
( phrenia. Arch Gen Psychiatry 1999;56:155-61.
於由，後療治物藥用使在 多過泌分胺巴多的內體於 ) 5. Shwardt BD, McGlinn T, Winstead DK: Disordered
胺巴多的內膜網視成造，少減性面全的量泌分胺巴多 spatiotemporal processing in schizophrenics. Biol
中驗實本在。象現的損缺野視現出而進，低過對相也 Psychiatry 1987; 22:688-98.
蹤追診門比遠感體立其，患病裂分神精的中院住現發 6. Slaguis WL. Contrast sensitivity for stationary and
巴多內體著表代否是，象現退衰的度幅大現呈人病的 drifting spatia frequency granting in positive and
論推們我？呢退減的感體立起引會時同也，少減的胺 negative symptom schizophrenia. J Abnorm Psychol
常非，患病院住的 期作發性急於處
(Acute psychosis) 1998: 107:49-62.
易容，後量劑與物藥科神精他其加增間時同為因能可 7. Schwartz BD, Nelson AV, Wall M, Winstead DK:
在以所，差變力斷判的置位對相間空與穩不履步成造 Visual evoked potentials associated with neural
得 顯作工 護照的 倒跌防 預的 患病類 此對強 加上床 臨 filter mechanisms in schizophrenia. New Trends in
Experimental and Clin Psychiatry 1985;1:179-86.
否是度合配其者患的中院住疑質人有許或。要重當相
7. 誌醫眼中 2009;48(2):153-160 究研之感體立患病症裂分神精區地灣台 159
8. Zemon V, Siegfried J, Gordon J. Magno and parvo 28: 297-300.
pathways in human studies using VEPs to lumi- 22. Shih YF, Lin Luke LK. Stereoacuity in anisometro-
nance and chromatic contrast (abstract). Invest oph- pes. Taiwan J Ophthalmol 1986; 25: 663-7.
thalmol Vis Sci 1991;32:1033. 23. Marsh WR, Rawlings SC, Mumma JV. Evaluation
9. Tychsen L. Binocular vision. In : William MH, ed. of clinical stereoacuity tests. Opthalmology 1980;
Adler’s Physiology of the eye, 9th ed. St. Louis: 87: 1265-72.
Mosby 1992: 773-853. 24. Merigan WH, Maunsell JHR: How parallel are the
10. Adams WE, Leske DA, Hatt SR, Mohney BG, Birch primate visual pathways. Annu Rev Neurosci 1993;
EE, Weakley DR Jr, Holmes JM. Improvement in 16:369-402.
distance stereoacuity following surgery for inter- 25. Nishida Y, Hayashi O, Iwami T, Kimura M, Kani K,
mittent exotropia. J AAPOS 2008Apr; 12(2): 141-4. Ito R, Shiino A, Suzuki M. Stereopsis-processing
11. Menon GJ, Wong KK, Bundhun T, Ewings P, regions in the human parieto-occipital cortex.
Twomey JM. The effect of Nd:YAG laser posterior Neuroreport 2001; 12(10):2559-63.
capsulotomy on stereoacuity. Eye 2007 Aug; 3: 1-4. 26. Butler PD, Schechter I, Zemon V, Schwart SG,
12. Patterson R, Martin WL. Human stereopsis. Human Greenstein VC, Gordon J, Eschroeder CE, Javitt DC.
factors 1992; 34(6): 669-92. Dysfunction of early-stage visual processing in
13. Scott WE, Marsh J. Stereoacuity in normal indivi- schizophrenia. Am J Psychiary 2001: 158:1126-33.
duals. Ann Ophthalmol 1974;6:99 27. Chen Y, Palafox GP, Nakayama K, Levy DL,
14. Simons K. Stereopsis norms in young children. Mattysse S, Holzmah PS. Motion perception in schi-
Arch ophthalmol 1981; 99:439-45. zophrenia. Arch Gen Psychiatry 1999;56: 149-54.
15. Hong SW, Park SC. Development of distant 28. Braff DL, Saccuzzo DP. Effects of antipsychotic
stereoacuity in visually normal children as measured medication on speed of information processing in
by the Frisby-Davis distant stereotest. Br J ophthal- schizophrenic patients. Am J Psychiatry 1982; 139:
mol. 2008; 92(9):1186-9. 1127-30.
16. Norman JF, Norman HF, Craft AE, Walton CL, 29. Butler PD, Harkavy-Friedman JM, Amador XF,
Bartholomew AN, Burton CL, Weisemann EY, Gorman JM. Backward masking in schizophrenia:
Crabtree CE. Stereopsis and aging. Vision Res. relationship to medication status, neuropsychologi-
2008;48(23-24):2456-65. cal functioning, and dopamine metabolism. Biol
17. Laframboise S, De Guise D, Faubert J. Effect of psychiatry 1996; 40:295-8.
aging on stereoscopic interocular correction. Optom 30. Bodis-Wollner I. Visual deficits related to dopamine
Vis Sci 2006; 83:589-93. deficiency on experimental animals and Parkinson’s
18. Schechter I, Butler PD, Jalbrzikowski M, Pasternak disease patients. Trends neurosci 1990; 13:296-302.
R, Saperstein AM, Javitt DC. A new dimension of 31. Haegerstrom-Portnoy G, Schneck ME, Brabyn JA.
sensory dysfunction: stereopsis deficits in schizo- Seeing into old age: vision function beyond acuity.
phrenia. Biol Psychiatry 2006 Dec;60(11):1282-4. Optom Vis Sci 1999; 76:141-58.
19. Rutstein RP. Update on accommodative esotropia. 32. Wright LA, Wormald RPL. Stereopsis and aging.
Optometry 2008; 79:422-31. Eye 1992; 6:473-6.
20. Levy NS, Glick EB. Stereoscopic perception and 33. Garnham L, Sloper JJ. Effect of age on adult
Snellen visual acuity. Am J Ophthalmol 1974;78: stereoacuity as measured by different types of
722-4. stereotest. Br J Ophthalmol 2006; 90: 90-5.
21. Lin Luke LK, Chang SH. Comparative study of 34. Leventhal AG, Wang Y, Pu M, Zhou Y, Ma Y. GABA
stereoacuities between monocular and binocular and its agonists improved visual cortical function in
refractional amblyopes. Taiwan J Ophthalmol 1989; senescent monkeys. Science 2003; 300:812-5.
8. 160 等 霖明蔡 傳信胡 Taiwan J Ophthalmol 2009. Vol 48. No 2
A PRIMARY STUDY ON THE STEREOPSIS IN
PATIENTS WITH SCHIZOPHRENIA IN TAIWAN
Hsing-chuan Hu1, Ming-Ling Tsai2 ,
Dong-Sheng Tzeng3, Wei-Tsung Kao3 Nan-Fu Chen4,
Chiang-Hsiang Lu2 , Chi-Ting Horng1,5
Purpose: To evaluate stereopsis in patients with was worse than in normal subjects (140.5±3.99 vs 43.5
schizophrenia in Taiwan ±4.6 msec; p<0.005), the stereopsis of male patients
Methods: 130 patients with schizophrenia and 80 was worse than female ones (271.0±92.6 vs 120.5±3.7
healthy volunteer subjects (at various ages) were msec ; p<0.005) in experiment 2. In experiment 3, the
enrolled into our study. All experiments were designed older the patient, the worse the stereopsis was (56.7±
to compare the results of the stereopsis. In experiment 1, 28.3 vs 70.9±39.9 vs 205.7±87.5 vs 240.8±76.4 vs
we compared the normal subjects and outpatients with 300.6±41.4 msec ; p<0.005). The poor stereopsis of the
schizophrenia. Experiment 2 was designed to compare inpatients was noted compared with outpatients (140.2±
stereopsis between male and female outpatients. 3.8.5 vs 720.4±56.6 msec; p<0.005) in experiment 4.
Experiment 3 was conducted to determine the different- Conclusion: The results clearly indicated the
ces between ages from 20-29/30-39/40-49/50-59/60-69 stereopsis of patients with schizophrenia is worse than
among patients with schizophrenia. In experiment 4, we in normal subjects, in particular male and older patients.
analyzed the stereopsis between outpatients and in- Because schizophrenia is a kind of chronic disease,
patients. The method of Timtus (cycles) was used to patients all require long-term care. Because of the poor
evaluate the results of stereopsis (ranging from 800 to stereopsis, they cannot exactly analyze the location of
40 msec). objects. As a result, we should pay attention to the
Result: According to the analysis conducted in ex- injuries occurring by accident, such as from walking
periment 1: the stereopsis in patients with schizophrenia unsteadily or falling down.
Received: January, 22, 2009. Revised: February, 26, 2009. Accepted: March, 10, 2009.
1
Department of Ophthalmolgy, 3Department of Psychiatry 4Division of neurosuerygy, Department of surgery
Kaohsiung Armed Forced General Hospital.
2 5
Department of Ophthalmolgy, Tri-Service General Hospital Department of Pharmacy, Tajen university.
Correspondence and reprint requests to: Chi-Ting Horng Department of Ophthalmolgy, Kaohsiung Armed Forced
General Hospital. 2, Chung-Chen 1st. Rd., Kaohsiung, Taiwan. 802 E-mail:h560411@ms5.hinet.net
