2. you

3. DNA sequencing is
becoming cheaper,
faster, and
better

4. Moore’s Law
Number of transistors on a chip
roughly doubles every two years

7. How much can your
genome tell you?
What can’t it tell you?

8. The $1000 genome
Can tell you Cannot tell you
• Parentage • Psychology
• Ancestory • Life history
• Risk for • Learned behavior
mendelian
diseases

11. Your genome for $1000
Would you want to know?

12. DNA sequencing
is more than just
sequencing DNA

14. DNA -> RNA -> Protein
(The Central Dogma)

15. Cancer is caused by DNA
mutations
Cancer is a word for
thousands of diseases

16. Cancer
vs.
Evolution

17. Pharmacogenomics

18. Disease is a stage in a
dynamic process, not a
static point in time

19. Personalized,
predictive,
prevention

20. DNA is what makes you
who you are, but you are a
lot more than just your DNA

21. DNA is extremely useful so
take advantage of it. Don’t
be afraid of it, but recognize
its limitations.

22. DNA is cheap, fast, and easy
to sequence.
Understanding what it
means is the hard part.

23. The Thousand Genomes Project
Free for download
on Amazon Cloud.
All 200 Terabytes of it.

25. “I think the biggest innovations of
the 21st century will be at the
intersection of biology and
technology. A new era is beginning.”
Steve Jobs (1955-2011)

26. Videos
• Richard Resnick - TEDxBoston 2011: Welcome to the
genomic revolution
• George Church – TEDMED 2010: Personal genomes
• Greg Lucier – TEDMED 2010: When will the genomic
medicine revolution finally happen?
• Barry Schuler – TED Taste 2008: Genomics 101
• Juan Enriquez – TED 2003: On genomics and our
future

27. Books
• Lone Frank: My beautiful genome (2011)
• Kevin Davies: The 1000$ genome (2010)
• Misha Angrist: Here is a human being (2010)
• Francis S. Collins: The language of life (2010)