Slide seires shows the course of my career. The talk was given to two sets of postgraduate students enrolled in psychology and neuroscience courses at Aarhus University. There are photos of most of the teachers and researchers that meant most to me during my academic life.

1. My Way in Biopsychology
Donald F. Smith
Translational Neuropsychiatry Unit
Institute of Clinical Medicine
Aarhus University

3. https://www.youtube.com/watch?v=2Ox1Tore9nw
As the snow flies
On a cold and gray Chicago mornin'
A poor little baby child is born
In the ghetto
And his mama cries
Cause if there's one thing that she don't need
It's another hungry mouth to feed
In the ghetto
People, don't you understand
The child needs a helping hand
Or he'll grow to be an angry young man some
day

4. My house
Ghetto
Stock Yards =
Slaughterhouse
Downtown

5. Briefly describe the US Public School System
1950 - 1963
Horace Mann Grammar School South Short Public High School

6. James Dewey Watson was born in Chicago, Ill., on April 6th, 1928. Young Watson's entire boyhood
was spent in Chicago where he attended Horace Mann Grammar School (1933 – 1941) and
South Shore High School (1941 – 1943). He then received a tuition scholarship to the
University of Chicago, and in the summer of 1943 entered their experimental four-year college.
In 1947, he received a B.Sc. degree in Zoology. From September 1950 to September 1951 he spent his
first postdoctoral year in Copenhagen as a Merck Fellow of the National Research Council.
The Nobel Prize in Physiology or Medicine 1962
Francis Crick, James Watson, Maurice Wilkins
http://www.nobelprize.org/nobel_prizes/medicine/laureates/1962/watson-bio.html

7. Mention Alfred J. Lewy ("Sandy Lewy“), Russ Chadwick and Ray Cahnman

8. 1963

9. University of Illinios
Psychology 101
Turning-Point Lecture
Demo

10. Thorndike’s Law of Effect:
”Organisms tend to repeat and learn responses
that lead to tension reduction and the
completion of motivated activity.”
Learning and Motivation
Pavlovian Classical Conditioning
Thorndike’s Operant Conditioning
Edward L. Thorndike
Columbia University
Ivan Pavlov
Military Medical Academy
Institute of Experimental Medicine
St. Petersburg

12. 1963
1965

13. Robert P. Erickson & family
Duke University – 1969
Psychology Department
Mention Discussion of Neurogenesis
The neural code for taste
Robert P. Erickson et al.
Brain Research, Volume 23, Issue 3, 1970,428–432
‘Across-Fiber Pattern' analysis of populations of
individual neurons
Physiological Psychology
Robert Erickson & wife
ca. 2014

14. LiCl
KCl
KCl
NaCl
NaCl

15. Physiological Psychology
Understand and describe behavior
by the laws of physics and chemistry

17. 1963
1965
1967
BSc
1967

19. 1963
1965
1967
BSc
1967

20. Edward Stricker
Physiological Psychology
McMaster University
University of Pittsburgh
since 1971

21. 1. Smith DF, Stricker EM. The influence of need on the rat's preference for dilute NaCl
solutions. Physiol Behav 1969:4:407-410.
2. Smith DF, Stricker EM, Morrison GR. NaCl solution acceptability by sodium deficient
rats. Physiol Behav 1969:4:239-243.

22. 1963
1965
1967
BSc
1968

23. University of Chicago, Department of Biopsychology,
Pritzker School of Medicine

24. The Spirit at the U of C

25. Heinrich Klüver

26. Biopsychology examines the interaction
between biological systems and behavior.

27. Physiological Basis of Motivational Processes
Central Molecular Mechanisms Governing
Eating and Drinking
Sebastian P. Grossman
Head of Department

28. Saul Balagura
Biopsychology Dept.
University of Chicago
Reminder: Myer Lubran statement on next slide

29. ”He who follows the masters, will always follow the masters!”
Dr. Myer Lubran
Head of Clinical Chemistry
Medical School
University of Chicago Hospital

30. Louis Seiden
Psychopharmacology
University of Chicago
John A. Harvey
Neuropsychopharmacology
University of Chicago

31. Dwight J. Ingle
Head of Physiology Department
Pritzker Medical School
University of Chicago
Chief Editor of American Journal
of Physiology
Founder of ”Perspectives in Biology
and Medicine”

32. 3. Smith DF, Balagura S. The role of oropharyngeal factors in LiCl aversions. J Comp Physiol
Psychol 1969:69:3O8-31O.
4. Smith DF, Balagura S, Lubran M. Some effects of adrenalectomy on LiCl intake and excretion
in the rat. Am J Physiol 197O:218:751-754
5. Smith DF, Balagura S, Lubran M. "Antidotal thirst": A response to intoxication. Science
197O:167:297-298.
6. Balagura S, Smith DF. Role of LiCl and environmental stimuli on generalized learned aversion
to NaCl in the rat. Am J Physiol 197O:219:1231-1234
7. Smith DF, Balagura S, Lubran M. Antidotal thirst and lithium excretion in rats with
hypothalamic lesions. Physiol Behav 1971:6:2O9-213.
8. Smith DF, Balagura S. Sodium appetite in rats given lithium. Life Sci 1972:11:1O21-1O29.
9. Smith DF, Balagura S. A method to study lithium, sodium, and potassium ions in rat CSF.
Physiol Behav 1972:9:261-262.
10. Smith DF, Balagura S. Taste and physiological need in vitamin C intake by guinea pigs. Physiol
Behav 1975:14:545-549.

33. Steve Jobs Quotes That Could Change Your Life
"Your work is going to fill a large part of your life, and the only way to be
truly satisfied is to do what you believe is great work. And the only way to do
great work is to love what you do. If you haven't found it yet, keep looking.
Don't settle. As with all matters of the heart, you'll know when you find it.“
https://www.linkedin.com/pulse/7-steve-jobs-quotes-could-change-your-life-jeff-haden?midToken=AQEwnyih2fp2PQ&trk=eml-b2_content_ecosystem_digest-recommended_articles-183-
null&fromEmail=fromEmail&ut=20c0WB5mAyB6I1

35. 1971PhD

37. Quebec
Aarhus

40. 11. Smith DF. Diurnal variations of lithium clearance in the rat. Int Pharmacopsychiatry 1973:8:99-1O3.
12. Smith DF, Smith HB. The effect of prolonged lithium administration on activity, reactivity, and endurance in the
rat. Psychopharmacology (Berlin) 1973:3O:83-88.
13. Smith DF, Thomsen K. Renal lithium clearance in adrenalectomized rats. Am J Physiol 1973:225:159-161.
14. Smith DF. The effect of exercise and pain-stress on renal clearance of lithium, sodium, potassium and creatinine
in the rat. Int Pharmacopsychiatry 1973:8:217-22O.
15. Smith DF. The effect of NH4Cl on polyuria and polydipsia during prolonged lithium administration in the rat.
Acta Pharmacol Toxicol (Copenh) 1974:34:121-129.
16. Smith DF. Renal lithium clearance during dehydration and rehydration with water or O.9 % NaCl in the rat. Acta
Physiol Scand 1974:9O:427-43O.
17. Smith DF. NH4Cl acceptability in the rat. Physiol Behav 1974:12:513-514.
18. Smith DF, de Jong W. Renal lithium, sodium, potassium and water excretion and plasma renin activity in rats in
the cold. Pharmacopsychiatria 1975:8:132-135.
19. Smith DF. Biogenic amines and the effect of short-term lithium administration on open field activity in rats.
Psychopharmacology (Berlin) 1975:41:295-3OO.
20. Smith DF. The role of sodium in the effect of food intake on renal lithium clearance in the rat. J Toxicol Appl
Pharmacol 1975:33:276-28O.
21. Smith DF. The role of alpha- and beta-adrenergic effects in the action of adrenaline on renal lithium elimination in
adrenalectomized rats. Eur J Pharmacology 1976:36:49-54.
22. Smith DF. Lithium orotate, carbonate and chloride: Pharmacokinetics, polydipsia and polyuria in rats. Br J
Pharmacol 1976:56:399-4O2.

41. 23. Smith DF. Reexamination of vertical activity in rats treated with lithium chloride. Experientia
23. 1976:32:132O-1321.
24. Smith DF, Shimizu M. Effect of posture on renal lithium clearance. Clin Sci 1976:51:1O3-1O5.
25. Smith DF. Antagonistic effect of lithium chloride on L-dopa-induced locomotor activity in rats. Pharmacol
25. Res Commun 1976:8:575-579.
26. Smith DF. Effects of tranylcypromine stereoisomers, clorgyline and deprenyl on open field activity during
long-term lithium administration in rats. Psychopharmacology (Berlin) 1976:50:81-84.
27. Smith DF, Shimizu M, Schou M. Lithium absorption, distribution and clearance and the body temperature in
rats given lithium plus haloperidol. Pharmacology 1977:15:337-34O.
28. Smith DF. Locomotor activity and plasma, red blood cell and cerebral cortex lithium concentration in inbred
mice given lithium carbonate. Pharmacol Biochem Behav 1976:5:379-382.
29. Smith DF, Shimizu M. Effects of alpha methyltyrosine and parachlorophenylanine on open field behavior
in rats given tranylcypromine stereoisomers and lithium carbonate. Pharmacol Biochem Behav
1976:5:515-518.
30. Smith DF, Shimizu M. Aggression in groups of rats given tranylcypromine stereoisomers: Effect of alpha-
methyltyrosine and parachlorophenylalanine. Agressologie 1977:18:17-19.
31. Smith DF, Shimizu M. Toxic interaction between disulfiram and tranylcypromine stereoisomers in rats. J
Pharm Pharmacol 1976:28:858.
32. Smith DF. The effects of lithium on behavior: Critical analysis of a school-of-thought. Compr Psychiatry
1977:18:449-452.
33. Shimizu M, Smith DF. Salivary and urinary lithium clearance while recumbent and upright. Clin Pharmacol
Ther 1977:21:212-215.
34. Smith, DF. Studies on hyperactivity in rats given tranylcypromine stereoisomers and reserpine. Arch Int
Pharacodyn Ther 1977:229:129-132.
35. Smith DF. Learned aversion and rearing movement in rats given LiCl, PbCl2 or NaCl. Experientia
1978:34:12OO-12O1.
36. Shimizu M, Smith DF. Relationship between clearance of lithium, potassium and sodium in human mixed
saliva. Int Pharmacopsychiatry 1978:13:34-38.
37. Smith DF, Shimizu M. The role of plasma volume, plasma renin and the sympathetic nervous system in the
posture-induced decline in renal lithium clearance in man. Neuropsychobiology 1978:4:328-332.

45. 38. Smith DF. Lithium chloride toxicity and pharmacodynamics in inbred mice. Acta Pharmacol. Toxicol (Copenh) 1978:43:51-54.
39. Smith DF. Irritable aggression and open field behavior in rats given 2-phenylcyclopropylamaines. Eur J Pharmacol 1978:52:297-3O2.
40. Ebara T, Smith DF. A method to determine lithium content in blood platelets. Acta Pharmacol Toxicol (Copenh) 1979:44:238-24O.
41. Smith DF. Hindlimb extensor reflex of spinal rats given tranylcypromine stereoisomers. J Neural Transm 1979:44:3O3-3O7.
42. Hoffman C, Smith DF. Lithium and rubidium: Effects on the rhythmic swimming movement of jellyfish (Aurelia aurita).
Experientia 1979:35:1177-1178.
43. Ebara T, Smith DF. Lithium levels in blood platelets, serum, red blood cells and brain regions in rats given acute or chronic lithium salt treatment. (Title in
Japanese) No To Shinkei (Brain and Nerve) 1979:31:177-183.
44. Ebara T, Smith DF. A method for determination of lithium content in blood platelets. (Title in Japanese) No To Shinkei (Brain and Nerve) 1979:31:289-293.
45. Ebara T, Smith DF. Lithium levels in blood platelets, serum, red blood cells and brain regions in rats given acute or chronic lithium salt treatment. J Psychiatr
Res 1979:15:183-188.
46. Smith DF, Vestergaard P. The role of monoamines for the central effects of baclofen on behavior of rats. J Neural Transm 1979:46:215-223.
47. Smith DF. Central and peripheral effects of lithium on conditioned taste aversions in rats. Psychopharmacology (Berlin) 198O:68:215-223.
48. Smith DF. Role of monoamines in behavior of reserpinized rats given tranylcypromine stereoisomers. J Neural Transm 1981:5O:193-2OO.
49. Smith DF. Central and peripheral effects of lithium on amphetamine-induced hyperactivity in rats. Pharmacol Biochem Behav 1981:14:439-442.
50. Jensen TS, Smith DF. The role of consciousness in stress-induced analgesia. J Neural Transm 1981:52:55-6O.
51. Hjorth M, Bille M, Smith DF. Serum tryptophan levels in alcoholics. Drug Alcohol Depend 1981:7:157-161.
52. Smith DF, Strömgren LS. Influence of unilateral ECT on tryptophan metabolism in endogenous depression. Pharmacophychiatria 1981:14:135-138.
53. Smith DF, Amdisen A. Lithium distribution in rat brain after long-term central administration by minipump. J Pharm Pharmacol 1981:33:8O5-8O6
54. .
54. Jensen TS, Smith DF. Dopaminergic effects on tail-flick response in spinal rats. Eur J Pharmacol 1982:79:129-133.
55. Smith DF. Effects of age on serum tryptophan and urine indican in adults given a tryptophan load test. Eur J Drug Metab Pharmacokinet 1982:7:55-68.
56. Jensen TS, Smith DF. Effect of emotions on nociceptive threshold in rats. Physiol Behav 1982:28:597-599.
57. Jensen TS, Smith DF. Monoaminergic mechanisms in stress-induced analgesia. J Neural Transm 1982:53:247-255.
58. Smith DF, Petersen HN. Stereoselective effects of tranylcypromine enantiomers on brain serotonin. Life Sci 1982:31:2449-2454.
59. Smith DF. Lithium and carbamazepine: Effects on learned taste aversion and open field behavior in rats. Pharmacol Biochem Behav 1983:18:484-488.
60. Hoffmann C, Smith DF. Lithium and rubidium: Effects on locomotion of planaria (Dendrocoelum lacteum). Experientia 1983:39:179-18O.
61. Jensen TS, Smith DF. Role of 5-HT and NA in spinal dopaminergic analgesia. Eur J Pharmacol 1983:86:65-70.
62. Smith DF, Amdisen A. Central effects of lithium in rats: Lithium levels, body weight and water intake. Acta Pharmacol Toxicol 1983:52:81-85.
63. Jensen TS, Smith DF. Stimulation of spinal dopaminergic receptors: Differential effects on tail reflexes in rats. Neuropharmacology 1983:22:477-483.

46. 64. Jensen TS, Schrøder HD, Smith DF. The role of spinal pathways in dopamine mediated alteration in the tail-flick reflex in rats.
Neuropharmacology 1984:23:149-153.
65. Smith DF. Stereoselectivity of spinal neurotransmission: Effects of baclofen enantiomers on tail-flick reflex in rats. J Neural Transm 1984:6O:63-67.
66. Smith DF, Strömgren E, Petersen HN, Williams DG, Sheldon W. Lack of effect of tryptophan treatment in demented gerontopsychiatric patients. Acta
psychiatr scand 1984:7O:47O-477.
67. Jensen TS, Smith DF. Selective association in conditioned stress-induced analgesia: Functional differences in interoceptive and exteroceptive sensory
pathways. Behav Neural Biol 1985:43:218-221.
68. Smith DF. Species differences in the velocity and stereoselectivity of platelet 5-HT-uptake in rats and humans. Acta Pharmacol et Toxicol 1985:57:3O1-3O3.
69. Tuomisto J, Smith DF. Effects of tranylcypromine enantiomers on monoamine uptake and release and imipramine binding. J Neural Transm 1986:65:135-
145.
70. Smith DF, Pirkle WH. Stereoselective analysis of racemic psychotropic compounds by HPLC on chiral stationary phase. Psychopharmacology 1986:89:392-
393.
71. Jensen TS, Christensen NJ, Smith DF. Differential effects of apomorphine on spinal reflex activity following 6-Hydroxydopamine or long-term haloperidol
pretreatment. J Neural Transm 1986:65:125-134.
72. Hagensen D, Smith DF. Central lithium injection induces seizures in reserpinized rats: role of serotonin. IRCS Med Sci 1986:14:919.
73. Enig B, Petersen HN, Smith DF, Larsen B. Food preferences, nutrient intake and nutritional status in cancer patients. Acta Oncologica 1987:26:1-5.
74. Smith DF. Lithium attenuates clonidine-induced hypoactivity: Further studies in inbred mouse strains. Psychopharmacology 1988:94:428-43O
.
75. Smith DF. Lithium alters the stereoselectivity of monoamine oxidase in rat brain. J Neural Transm 1989:76:2O5-21O.
76. Petersen HN, Smith DF, Enig B. The severity of depression in cancer patients. Scand J Psychol 1988:29:126-128.
77. Smith DF, Hokland M. Love and salutogenesis in late adolescence: A preliminary investigation. Psychology - A Journal of Human Behavior 1988:25:44-49.
78. Sterndorff B, Smith DF. Normal values for type A behavior patterns in Danish men and women in potential high-risk groups. Scand J Psychol 1990:31:49-54.
79. Christensen M-K, Smith DF. Antinociceptive effects of the stereoisomers of nicotine given intrathecally in spinal rats. J Neural Transm 1990:80:189-194.
80. Smith DF. Effects of lithium and rolipram enantiomers on locomotor activity in inbred mice. Pharmacol Toxicol 1990:66:142-145.
81. Tytgat D, Gelbcke M, Smith DF. Convenient synthesis of chiral 1-phenyl-1,2-propranediamines. Preliminary pharmacological results. Pharmacie,
1990:45:835-836.
82. Smith DF. How to study effects of lithium on spatial features in macromolecules: actions on the stereoselectivity of rat brain monoamine oxidase. In: Sandler
M, Dahlström A, Belmaker RH, eds. Progress in Catecholamine Research. Part B: Central Aspects. New York: Alan R. Liss, 1988, 371-375.
83. Smith DF. Molecular mechanisms of action of lithium: effect on the stereoselectivity of rat brain MAO. In: Birch NJ, ed. Inorganic Pharmacology and
Psychiatric Use. IRL Press: Oxford, 1988, 333-334.
84. Smith DF, Jensen PN, Poulsen SH, Mikkelsen O, Elbaz E, Glaser R. Effects of pyrroloisoquinoline enantiomers ((+)- and (-)-McN-5652-Z) on serotonergic
mechanisms in rats:Locomotor activity, paroxetine binding, monoamine oxidase activity, 5-HT uptake and 5-HT-induced vasocontraction. European J
Pharmacology 1991:196:85-91.

47. Quebec
Aarhus

48. 1991
2012
Burnout, sense of coherence and sources of
salutogenesis in social workers.
Baker, Martyn; North, Daniel; Smith, Donald F.
Psychology: A Journal of Human Behavior,
Vol 34(1), 1997, 22-26.

49. 85. Smith DF, Sterndorff B. Female physicians outscore male physicians and the general public on Type A scales in Denmark.
Behavioral Medicine 1991:17:184-189.
86. Smith, DF, Jensen PN, Gelbcke M, Tytgat D. Effects of 3,N,N'-trimethyl-2-phenyl-1,4-piperazine diastereomers on
monoamine uptake and monoamine oxidase in rat brain. Journal of Neural Transmission 1992:88:177-185.
87. Smith, D.F., Sterndorff, B. Coronary-prone behavior may be declining in Danish men and women. Scand J Psychol 1993:34:
379-383.
88. Soerensen, J.B., Smith, D.F. Enhancement of Y-maze learning by piracetam, 2-thio-1- pyrrolidine-acetamide and 2-thio-1-
pyrrolidine-thio-acetamide in rats. J. Neural Transm (P-D Sect) 6:139 - 144, 1993.
89. Smith, D.F. Type A personalities tend to have low platelet monoamine oxidase activity. Acta Psychiatr
Scand. 89: 88-91, 1994.
90. Licht, R.W., Larsen, J.O., Smith, D., Brændgaard, H. Effect ofchronic lithium treatment with or without
haloperidol on number and sizes of neurons in rat neocortex. Psychopharmacology,115: 371-374, 1994.
91. Jensen, P.N., Smith, D.F., Poulsen, J.H., Møller, H.J., Rosenberg, R. Effect of flunarizine and calcium on
serotonin uptake in human and rat blood platelets and rat synaptosomes. Biol.Psychiatry, 36: 118-123, 1994.
92. Wardle, J., Steptoe, A., Smith, H., Groll-Knapp, E., Koller, M., Smith, D., Brodziak, A. Breast self-
examination: attitudes and practices among young women in Europe. European J. Cancer Prevention, 4: 61-68, 1995.
93. Chahboun, S., Gelbcke, M., Smith, D.F. Antidepresseurs potentiels: Synthese et stereochimie de 2,3,4,4a,9,9a-
hexahydro-9-phenyl-1H-indeno[1,2-b]pyraxines. Bull. Soc. Chim. Belg., 104:613-622, 1995.
94. Gee, A.D., Smith, D., Gjedde, A. The synthesis of [O-methyl-11C]venlafaxine: A potential tracer of the 5-HT reuptake site. J.
Labelled Comp. Radiopharm., 37: 309-310, 1995.95. Smith, D.F., Glaser, R., Gee, A., Gjedde, A. [11C]-
Nefopam as a potential PET tracer of serotonin reuptake sites. Initial findings in living pig brain. In:
Quantification of Brain Function Using PET. Myers, R., Cunningham, V.J., Bailey, D.L., Jones, T. (eds). Academic
Press, San Diego, 1996, pp. 49-53.
96. Smith, D.F., Sterndorff, B., Røpcke, G., Gustavsen, E.M., Hansen, J.K. Prevalence and severity of anxiety, depression and
Type A behaviors in angina pectoris. Scand. J. Psychology, 37: 249 – 258, 1996.
97. Gee, A.D., Smith, D.F., Gjedde, A. The synthesis of [O-methyl-11C]venlafaxine: A non- classical, fast-acting antidepressant.
J. Labelled Comp.Radiopharm., 39: 89 - 95, 1997.
98. Licht, R.W., Smith, D.F., Brændgaard, H. The effect of chronic lithium treatment on the calibre of axons and nerve fibres in
the rat sural nerve.Euro. Neuropsychopharm., 7: 95 - 98, 1997.
99. Smith, D.F., Jensen, P.N., Gee, A.D., Hansen, S.B., Danielsen, E., Andersen,F., Saiz, P.-A., Gjedde, A. PET neuroimaging with
[11C]venlafaxine: serotonin uptake inhibition, biodistribution and binding in living pig brain. Euro. Neuropsychopharm., 7:
195 - 200, 1997.
100. Baker, M., North, D., Smith, D.F. Burnout, sense of coherence and sources of salutogenesis n social workers. Psychology, A
Journal of Human Behavior, 34: 22 - 26, 1997.
101. Wegener, G., Smith, D.F., Rosenberg, R. 5-HT1A receptors in lithium-induced conditioned taste aversion.
Psychopharmacology, 133: 51-54,1997.

50. Quebec
Aarhus

54. 102. Poulsen, P.H., Smith, D.F., Østergaard, L., Danielsen, E.H., Gee, A., Hansen, S.B., Astrup,
J., Gjedde, A. In vivo estimation of cerebral blood flow, oxygen consumption and glucose
metabolism in the pig by [15O]water injection, [15O]oxygen inhalation and dual injections of
[18F]fluorodeoxyglucose. J. Neurosci. Methods, 77: 199 - 209, 1997.
103. Østergaard, L., Smith, D.F., Vestergaard-Poulsen, P., Hansen, S.B., Gee, A., Gjedde, A.,
Gyldensted, C. Absolute cerebral blood flow and blood volume measured by magnetic resonance
imaging bolus tracking: Comparison with positron emission tomography values. J. Cereb. Blood
Flow Metab., 18: 425 - 432, 1998.
104. Danielsen, E., Smith, D.F., Poulsen, P.H., Østergaard, L., Gee, A., Ishizu, K.,
Venkatachalam, T.K., Bender, D., Hansen, S., Gjedde, A., Scheel-Krüger, J., Møller, A.
Positron emission tomography of living brain in minipigs and domestic pigs. Scand. J. Lab.
Anim. Sci. Suppl. 1., 25: 127 – 135, 1998.
105. Smith, D.F., Poulsen, P.H., Ishizu, K., Sakoh, M., Hansen, S.B., Gee, A.D., Bender, A.D.,
Gjedde, A. Quantitative PET analysis of regional cerebral blood flow and glucose and
oxygen metabolism in response to fenfluramine in living porcine brain. J. Neurosci. Methods, 86:
17 – 23, 1998.
106. Smith, D.F., Gee, A.D., Hansen, S.B., Moldt, P., Østergaard Nielsen, E., Scheel-Krüger, J.,
Gjedde, A. Uptake and distribution of a new SSRI, NS2381, studied by PET in living porcine brain.
European Neuropsychopharmacology, 9: 351-359, 1999.
107. Danielsen, E.H., Smith, D.F., Gee, A.D., Venkatachalam, T.K., Hansen, S.B., Hermansen,
F., Gjedde, A., Cumming, P. Cerebral 6-[18F]fluoro-L-dopa (FDOPA) metabolism in pig studied by
positron emission tomography. Synapse, 33: 247-258, 1999.
108. Smith, D.F. Neuroimaging of serotonin uptake sites and antidepressant binding sites in the
thalamus of humans and 'higher' animals. European Neuropsychopharmacology, 9: 537-
544, 1999.
109. Simonsen, C.Z., Østergaard, L., Smith, D.F., Vestergaard- Poulsen, P. and Gyldensten, C.
Comparison of gradient- and spin-echo imaging: CBF, CBV, and MTT measurements by bolus tracking.
J. Magn. Reson. Imaging, 12: 411-416, 2000.
110. Ishizu, K., Smith, D.F., Bender, D., Danielsen, E., Hansen, S.B., Wong, D.F., Cumming, P.
and Gjedde, A. Positron emission tomography of radioligand binding in porcine
striatum in vivo: haloperidol inhibition linked to endogenous ligand release. Synapse, 38: 87-101, 2000.
111. Sakoh, M., Østergaard, L., Røhl, L., Smith, D.F., Simonsen,C.Z., Sørensen, J.C., Poulsen,
P.V., Gyldensted, C., Sakaki, S., Gjedde, A. Relationship between residual cerebral
blood flow and oxygen metabolism as predictive of ischemic tissue viability: sequential
multitracer positron emission tomography scanning of middle cerebral artery occlusion
during the critical first 6 hours after stroke in pigs. J. Neurosurg. 93: 647-657, 2000.
112. Cumming, P., Kretzschmar, M., Brust, P., Smith, D.F. Quantitative radioluminography of
serotonin uptake sites in the porcine brain. Synapse, 39: 351-355, 2001.
113. Marthi, K., Bender, D., Smith, D.F. Synthesis of [N-methyl-11C]mianserin: a tetracyclic,
atypical antidepressant. J. Labelled Cpd. Radiopharm., 44: 121-126, 2001.
114. Cumming, P., Danielsen, E.H., Vafaee, M., Falborg, L., Steffensen, E., Sørensen, J.C.,
Gillings, N., Bender, D., Marthi, K., Andersen, F., Munk, O., Smith, D., Møller, A., Gjedde,
A. Normalization of markers for dopamine innervation in striatum of MPTP-lesioned
miniature pigs with intrastriatal grafts. Acta Neurol. Scand., 103: 309-315, 2001.
115. Smith, D.F., Bender, D., Marthi, K., Cumming, P., Hansen, S.B., Peters, D., Østergaard
Nielsen, E., Scheel-Krüger, J., Gjedde, A. Synthesis and evaluation of racemic [11C]NS2456
and its enantiomers as selective serotonin reuptake radiotracers for PET. Nuclear Medicine
and Biology, 28: 265-270, 2001.
116. Danielsen, E.H., Smith, D.F., Hermansen, F., Gjedde, A., Cumming, P. Acute neuroleptic
stimulates DOPA decarboxylase in porcine brain in vivo. Synapse, 41: 172-175, 2001.
117. Smith, D.F., Geday, J. PET neuroimaging of clomipramine challenge in humans: focus on
the thalamus. Brain Res., 892: 193-197, 2001.

55. 118. Cumming, P., Danielsen, E.H., Vafaee, M., Falborg, L., Steffensen, E., Sørensen, J.C.,
Gillings, N., Bender, D., Marthi, K., Andersen, F., Munk, O., Smith, D., Møller, A., Gjedde,
A. Normalization of markers of dopamine innervation in striatum of MPTP-lesioned
miniature pigs with intrastriatal grafts. Acta Neurol. Scand., 103: 309-315, 2001.
119. Smith, D.F., Hansen, S.B., Østergaard, L., Gee, A.D., Danielsen, E., Ishizu, K., Bender,
D., Poulsen, P.H., Gjedde, A. [14C]Serotonin uptake and [O-methyl-11C]velafaxine kinetics
in porcine brain. Nuclear Medicine and Biology, 28: 633-638, 2001.
120. Sakoh, M., Østergaard, L., Gjedde, A., Røhl, L., Vestergaard-Poulsen, P., Smith, D.F.,
Le Bihan, D., Sakaki, S., Gyldensted, C. Prediction of tissue survival after middle cerebral
artery occlusion based on changes in the apparent diffusion of water. J. Neurosurg. 95: 450-
458, 2001.
121. Danielsen, E.H., Smith, D.F., Andersen, F., Gee, A.D., Bender, D., Hansen, S.B.,
Hermansen, F., Østergaard, L., Cumming, P., Gjedde, A. FDOPA metabolism in the adult
porcine brain: influence of tracer circulation time and VOI selection on estimates of striatal
DOPA decarboxylation. J. Neurosci. Methods, 111: 157-168, 2001.
122. Marthi, K., Bender, D., Watanabe, H., Smith, D.F. PET evaluation of a tetracyclic,
atypical antidepressant, [N-methyl-11C]mianserin, in the living porcine brain. Nucl. Med. Biol.,
29: 317-319, 2002.
123. Marthi, K., Bender, D., Gjedde, A., Smith, D.F. [11C]Mirtazapine for PET neuroimaging:
radiosynthesis and initial evaluation in the living porcine brain. Eur.
Neuropsychopharmacol., 12: 427-432, 2002.
124. Jensen, S.B., Bender, D., Smith, D.F., Scheel-Krüger, J., Nielsen, E.Ø., Olsen, G.M.,
Peters, D., Gjedde, A. Synthesis of ( )3-(6-nitro-2-quinolinyl)[9-methyl-11C]-3,9-diazabicyclo-
[4.2.1] nonane ([11C-methyl]NS 4194). J. Label. Compd. Radiopharm., 45: 181-189, 2002.
125. Licht, R.W., Larsen, J.O., Smith, D., Braendgaard, H. Chronic lithium treatment with or
without haloperidol fails to affect the morphology of the rat cerebellum. Eur.
Neuropsychopharmacol., 13: 173-176, 2003.
126. Jensen, S.B., Smith, D.F., Bender, D., Jakobsen, S., Peters, D., Nielsen, E.Ø., Olsen,
G.M., Scheel-Krüger, J., Wilson, A., Cumming, P. [11C]-NS 4194 versus [11C]-DASB for PET
imaging of serotonin transporters in living porcine brain. Synapse, 49: 170-177, 2003.
127. Marthi, K., Hansen, S.B., Jakobsen, S., Bender, D., Smith, S.B., Smith, D.F.
Biodistribution and radiation dosimetry of [N-methyl-11C]mirtazapine, an antidepressant
affecting adrenoceptors. Applied Radiation and Isotopes, 59: 175-179,2003.
128. Cumming, P., Rosa-Neto, P., Watanabe, H., Smith, D., Bender, D., Clarke, P.B.S.,
Gjedde, A. Effects of acute nicotine on hemodynamics and binding of [11C]raclopride to
dopamine D2,3 receptors in pig brain. NeuroImage, 19: 1127-1136, 2003.
129. Marthi, K., Jakobsen, S., Bender, D., Hansen, S.B., Smith, S.B., Hermansen, F,
Rosenberg, R, Smith, D.F. [N-methyl-(11)C]Mirtazapine for positron emission
tomography neuroimaging of antidepressant actions in humans. Psychopharmacology,
174: 260-265, 2004.
130. Bender, D., Olsen, A.K., Marthi, M.K., Smith, D.F., Cumming, P. PET evaluation of the
uptake of N-[11C]methyl CP-643,051, an NK1 receptor antagonist, in the living porcine brain.
Nuclear Medicine and Biology, 31: 699-704, 2004.
131. Davanlou, M., Smith, D.F. Unbiased stereological estimation of different cell types in rat
cerebral cortex. Image Anal. Stereol. 23: 1-11, 2004.
132. Geday, J., Hermansen, F., Rosenberg, R., Smith, D.F. Serotonin modulation of cerebral
blood flow measured with positron emission tomography (PET) in humans. Synapse, 55: 224-
229, 2005.

56. 133. Smith, D.F., Marthi, K., Munk, O.L., Cumming, P., Hansen, S.B., Jakobsen, S. PET
neuroimaging of [11C]mirtazapine enantiomers in pigs. European
Neuropsychopharmacology, 16: 350-357, 2005.
134. Smith, D.F., Dyve, S., Minuzzi, L., Jakobsen, S., Munk, O.L., Marthi, K., Cumming, P.
Inhibition of [11C]mirtazapine binding by α2-adrenoceptor antagonists studied by positron
emission tomography in living porcine brain. Synapse, 59: 463-471, 2006.
135. Jakobsen, S., Pedersen, K., Smith, D.F., Jensen, S.B., Munk, O.L., Cumming, P. Detection
of α2-adrenergic receptors in brain of living pig with 11C-yohimbine. Journal of Nuclear
Medicine, 47: 2008-2015, 2006.
136. Smith, D.F., Stork, B.S., Wegener, G., Jakobsen, S., Bender, D., Audrain, H., Jensen, S.V.,
Hansen, S.B.,Rodell, A., Rosenberg, R. Receptor occupancy of mirtazapine determined by
PET in healthy volunteers, Psychopharmacology, 195: 131-138, 2007
137. Smith, D.F. and Jakobsen, S. Stereoselective neuroimaging in vivo. Eur.
Neuropsychopharm. 17:507-522, 2007
138. Smith, D.F., Hansen, S.B., Jakobsen, S., Bender, D., Auddrain, H., Ashkanian, M., Stork,
B.S., Minuzzi, L., Hall, H., Rosenberg, R. Neuroimaging of mirtazapine enantiomers in
humans. Psychopharmacology, 200: 273-279, 2008
139. Smith, D.F. and Jakobsen, S. Molecular tools for assessing human depression by positron
emission tomography. European Neuropsychopharmacology, 19: 611-628, 2009
140.Smith, D.F., Stork, B.S., Wegener, G., Ashkanian, M., Jakobsen, S., Bender, D., Audrain,
H., Vase, K.H., Hansen, S.B., Videbech, P., Rosenberg, R. [11C]Mirtazapine binding in
depressed antidepressant nonresponders studied by PET neuroimaging.
Psychopharmacology, 206:133-140, 2009
141. Guidi, S., Bianchi,P., Alstrup, A.K.O., Henningsen, K., Smith, D.F., Bartesaghi, R.
Postnatal
neurogenesis in the hippocampal dentate gyrus and subventricular zone of the Göttingen
minipig. Brain Research Bulletin, 85: 169-179, 2011.
142. Munk, O.L., Smith, D.F. PET kinetics of radiolabelled antidepressant [N-methyl-
11C]mirtazapine, in the human brain. European Journal of Nuclear Medicine and Molecular
Imaging Research, 1:36, 2011, Open access.
143. Smith, D.F., Gerdes, L.U. Meta-analysis on anxiety and depression in adult celiac disease.
Acta Psychiatrica Scand. 125: 189-193, 2012.

57. 144. Smith, D.F. Benefits of flavanol-rich cocoa-derived products for mental well-being: A review.
Journal of Functional Foods, 5: 10-15, 2013
145. Smith, D.F., Noedskov, H., Winterdahl, M., Lund, T.E. Replication attempt to estimate
depression severity by fuzzy logic analysis of emotion-focused fMRI. Journal of Magnetic
Resonance Imaging, 37: 498-499, 2013
146. Smith, D.F., Jakobsen, S. Molecular neurobiology of depression: PET findings on the
elusive correlation with symptom severity. Frontiers in Psychiatry, March 4, 2014 (doi:
10.3389/fpsyt.2013.00008
147. Smith, D.F. Quest for biomarkers of treatment-resistant depression: shifting the paradigm
toward risk. Frontiers in Psychiatry, June 18, 2013 (doi: 10.3389/fpsyt.2013.00057)
148. Winterdahl, M., Audrain, H., Landau, A.M., Smith, D.F., Bonaventure, P., Shoblock, J.R.,
Carruthers, N., Swanson, D., Bender, D. PET brain imaging of neuropeptide Y2 receptors
using N-[11C]methyl-JNJ-31020028 in pigs, Journal of Nuclear Medicine, 55: 1-5, 2014.
149. Smith, D.F. Systematic review of an emerging trend in China: resting-state functional connectivity in
major depressive disorder. Journal of Neuroscience and Clinical Neuroscience,
2014: doi: 10.1176/appi.neuropsych.13110343.

58. Review articles in peer-reviewed journals
1. Smith DF. Factors affecting renal lithium elimination. Medikon 1977:6:6-15.
2. Smith DF. Behavior of rats given lithium salts. A review. Pharmacopsychiatria 1977:10:79-88.
3. Smith DF. Tranylcypromine stereoisomers, monoaminergic neurotransmission and behavior. A minireview. Pharmakopsychiatr Neuropsychopharmakol 1980:13:130-136.
4. Smith DF. Stereopsychopharmacology: Past, present and future. Prog Neuropsychopharmacol & Biol Psychiat 1983:8:327-350.
5. Smith DF. Stereochemical considerations of the actions of some psychotropic drugs. Pharmacopsychiatia 1985:18:225-230.
6. Smith DF. The stereoselectivity of serotonin uptake in brain tissue and blood platelets: The topography of the serotonin uptake area. Neurosci Biobehav Rev 1986:10:37-46.
7. Smith DF. Wirkung von Lithium auf die Bewegungsaktivität von Versuchstieren. In: Müller-Oerlinghausen B, Greil W, eds. Die Lithiumtherapie. Nutzen, Risiken,
Alternativen. Berlin: Springer-Verlag, 1986, 51-59.
8. Smith DF. Common molecular features in antipsychotic drugs and the topography of their binding site. Nord Psykiatr Tidsskr 1987:41:475-481.
9. Smith DF. Introduction. In: Smith DF, ed. Handbook of Stereoisomers:Therapeutic Drugs. Boca Raton, Fl.: CRC Press Inc., 1989, pp. 1 -22.
10. Smith DF. Psychotropic drugs. In: Smith DF, ed. Handbook of Stereoisomers: Therapeutic Drugs. Boca Raton, Fl.; CRC Press Inc., 1989, pp. 438-456.
11. Smith DF. The stereoselectivity of drug action. Pharmacol Toxicol 1989:65:321-331.
12. Smith DF. Strategies in behavioral research on affective disorders: principles, problems and pitfalls. Pharmacol Toxicol 1990:66 (Suppl III):139-143.
13. Smith, D.F. MAO stereoselectivity. In: Lithium: New Applications. S. Johnson & F.N. Johnson (eds), Marius Press,Lancaster, 1993, pp. 314 - 317.
14. Smith, D.F. Negative emotions and coronary heart disease: Causally related or merely coexistent? A review. Scand. J. Psychol., 42: 57-70, 2001.
15. Smith, D.F. Functional salutogenic mechanisms of the brain. Perspectives in Biology and Medicine, 45: 319 – 328, 2002.
16. Smith, D.F. and Jakobsen, S. Stereoselective neuroimaging in vivo. Eur. Neuropsychopharm. 17:507-522, 2007.
17. Smith, D.F. and Jakobsen, S. Molecular tools for assessing human depression by positron emission tomography. European Neuropsychopharmacology, 19: 611-628, 2009.
18. Smith, D.F. Cognitive Brain Mapping for Better or Worse. Perspect. Biol. Med. 53(3): 321-329, 2010.
19. Smith, D.F. and Gerdes, L.U. Meta-analysis on anxiety and depression in adult celiac disease. Acta Psychiatr. Scand. 125(3): 189-193, 2012.
20. Alstrup, A.K.O. and Smith, D.F. PET neuroimaging in pigs. Scand. J. Lab. Anim. Sci. 39(1):25-45, 2012.
21. Smith, D.F., and Jakobsen, S. Molecular neurobiology of depression: PET findings on the
elusive correlation with symptom severity . Frontiers in Psychiatry 4, 1-15, 2013.

61. What’s the Score?
149 Original research reports in peer-reviewed journals
21 Review articles in peer-reviewed scientific journals
11 Book chapters
2 Handbooks as Chief Editor
3 Books on selected topics
Total: 186 Scientific Publications
Carrier of 45 years (1970 – 2015) = 540 months
540 / 186 = 2.9 months per publication
Academic Degrees
BSc Psychology Duke University
MA Physiological Psychology McMaster University
PhD Biopsychology University of Chicago
MSc Pharmacology Aarhus University
DMSc Psychiatry Copenhagen University

62. Official ”Thanks” to everyone who has ever worked at The Psychopharmacology
Research Unit, The Center for Psychiatric Research, and The Translational
Neuropsychiatry Unit at the Psychiatric Hospital in Risskov
as well as
The PET Center and CFIN at Aarhus University Hospital