Re-revised CV

CURRICULUM VITAE
John Samuel Striffler
Email Address: striffler.sam@gmail.com
PLACE OF BIRTH: Brooklyn, New York
MILITARY SERVICE: U.S. Naval Hospital Corps (HM-2)
EDUCATION:
Ph.D. University of California, Davis: Physiology (Metabolism) 1977
B.A. California State University, San Francisco: Biology (Chemistry) 1968
A.A. College of San Mateo, San Mateo, California: Zoology (Chemistry) 1961
COURSES TAUGHT OR ASSISTED:
Systemic Physiology Lecture and Laboratory (Non-Biology majors), Department of Biology,
California State University, San Francisco.
Systemic Physiology Laboratory (Biology majors), Department of Biology, California State University,
San Francisco.
Introductory Anatomy Laboratory (Non-biology majors), Department of Biology, California State
University, San Francisco.
Systemic Physiology (Biological Science majors), Teaching Assistant, Department of Physiology,
University of California, Davis.
Anatomy of Limbs (Human), Department of Anatomy and Cell Biology, University of Cincinnati
College of Medicine, Cincinnati, Ohio.
Radioimmunoassay Techniques (Biomedical Sciences Ph.D. Program), Department of Biological
Chemistry, Wright State University School of Medicine, Dayton, Ohio.
POSITIONS:
2007-present Visiting Scientist Diet, Genomics & Immunology Laboratory, Beltsville Human
Nutrition Research Center, Beltsville, Maryland
2005–2007 Chemist, Nutrient Requirements & Functions Laboratory, Beltsville Human Nutrition
Research Center, Beltsville, Maryland.
1999-2003 Research Associate, Endocrine Division, Department of Internal Medicine University of
Virginia, Charlottesville, Virginia.

J. S. Striffler, Page 2
1998-1999 Research Fellow, Department of Diabetes, Endocrinology & Metabolism, City of Hope
National Medical Center, Duarte, California.
1989-1997 Research Assistant Professor, Department of Human Nutrition and Food Systems,
University of Maryland, College Park, Maryland.
1987-1989 Research Assistant Professor, Department of Physiology, University of Maryland, School
of Medicine, Baltimore, Maryland.
1983-1986 Research Assistant Professor, Department of Biological Chemistry, Wright State University
School of Medicine, Dayton, Ohio.
1982-1984 Research Scientist (Sponsor: P.T. Varandani), Fels Research Institute, Wright State
University School of Medicine, Yellow Springs, Ohio.
1981-1982 Research Associate, Department of Anatomy & Cell Biology, University of Cincinnati
College of Medicine, Cincinnati, Ohio.
1979-1981 Postdoctoral Fellow (Sponsor: R.R. Cardell), Department of Anatomy, University of
Cincinnati College of Medicine, Cincinnati, Ohio.
1977-1979 Postdoctoral Fellow (Sponsor: R.R. Cardell), Department of Anatomy, University of
Virginia School of Medicine, Charlottesville, Virginia.
1974-1977 Research Assistantship (Dissertation: D.L. Curry), Department of Physiological Sciences,
University of California, Davis.
1973-1974 Research Assistantship (R.A. Freedland), Department of Physiological Sciences, University
of California, Davis.
1967-1970 Lecturer, Department of Biology, California State University, San Francisco,CA.
1965-1967 Teaching Assistant, Department of Biology, California State University, San Francisco, CA.
PROFESSIONAL SOCIETIES:
Endocrine Society, American Physiological Society, Society for Experimental Biology & Medicine
GRANT AWARDS:
P.H.S. Postdoctoral Fellowship AM 06013: Studies on Hepatic Carbohydrate Metabolism, 11/30/78-
11/30/81. Sponsor: R.R. Cardell, Department of Anatomy and Cell Biology, University of Cincinnati
Cincinnati, Ohio
NIH Grant AM 31010: Hepatic insulin metabolism in perfused liver-pancreases, 9/30/82 8/31/85 Dept
of Biological Chemistry, Wright State University, Dayton, Ohio.
Project Director, NSF Biochemistry Program Grant (PCM 8311556): "Acquisition of an Automatic
Gamma Counter" Equipment grant effective 2/1/84. Dept of Biological Chemistry, Wright State J. S.

Striffler, Page 3
University, Dayton, Ohio.
OTHER ACTIVITIES:
Consultant, NIH Grant AM 27097: Subcellular Effects of Metabolic Hormones on Rat Liver.
Principal Investigator: R.R. Cardell, Dept. of Anatomy and Cell Biology, University of Cincinnati,
Cincinnati, Ohio.
1990-92. Wrote grant applications for studies on nutritional, biochemical and physiological effects of
dietary chromium during employment with the USDA Vitamin & Mineral Nutrition Laboratory & the
University of Maryland.
1992-96. BHNRC Seminar Committee, 1994-95. Reviewer Journal of Nutrition; (USDA Internal
Reviewer).
1999-2000. Managed establishment of a colony of genetically hypertensive rats (SHRN-cp strain) at
the City of Hope Medical Center in Duarte California. Managed establishment of a breeding colony of
genetically lean Type 2 diabetic rats (G/K strain) at the City of Hope. Managed transfer and
establishment of breeding colonies of both diabetic rat strains at the University of Virginia in 2000.
Final Report to Cell Therapeutics Int. (Spring 2001): Effects of Lisofylline and LSF analogs on
glucose tolerance and insulin secretion, in vivo and in vitro.
Press Releases: Two abstracts have been published as Lay versions.
(1) Agricultural Research Service News (September 1999): Under the story lead - Chromium Critical
for Glucose Tolerance. Chromium decreases insulin responses to glucose in rats.
(2) Research Summaries for the 82nd Annual Meeting of the Endocrine Society (June 2000):
Lisofylline (LSF), a novel modulator of fatty acid metabolism, improves insulin secretion and glucose
tolerance in a rat model of type 2 diabetes mellitus (DM), p 18.
(3) News Release: PhytoMedical Technologies, Inc., Vancouver, BC. Expands Diabetes Research
Efforts With Addition of Key Scientists (2005).
SEMINAR PRESENTATIONS:
Fall ’80 Dept of Anatomy & Cell Biology, University of Cincinnati: Perfused Rat Liver-Pancreas
Preparations – Perfusion Technique & Metabolic Functions.
Fall ’82 Dept of Anatomy & Cell Biology, University of Cincinnati: Effect of Fasting on Liver
Removal of Insulin in Perfused Rat Liver-Pancreas Preparations.
Fall ’83 Dept of Physiology, Louisiana State University School of Medicine, New Orleans, LA: Insulin
Metabolism in Perfused Liver-Pancreas Preparations.

Fall ’84 Dept of Medicine, University of Florida, Gainesville, FL: Insulin Metabolism in Perfused Rat
Liver-Pancreas Preparations.
Fall ’84 Dept of Biological Chemistry, Wright State University, Dayton, Ohio: Hepatic Extraction of
Insulin in Perfused Rat Liver-Pancreas Preparations – Effect of Fasting.
Spr. ’88 Dept of Physiology, University of Maryland School of Medicine: Hepatic Insulin Metabolism
in Perfused Rat Liver-Pancreas Preparations.
Fall ’91 Vitamin & Mineral Nutrition Laboratory, USDA/BHNRC: Effects of Chromium on In Vivo.
Insulin and Glucose Responses in Rats.
Spr. ’92 USDA Beltsville Human Nutrition Research Center Journal Club: Receptor-Mediated
Clearance of Insulin in Perfused Rat Liver.
Fall ’92 Vitamin & Mineral Nutrition Laboratory, USDA/BHNRC: Insulin Metabolism and Chromium
Nutrition.
Fall ’94 Metabolism & Nutrient Interactions Laboratory, USDA/BHNRC: Effect of Perindopril on
Hypertension in Spontaneously Hypertensive Corpulent Rats.
Spr. ’95 Dept of Nutrition & Food Systems, University of Maryland, College Park: Insulin Metabolism
and Chromium Nutrition.
Fall '97 Dept of Diabetes, Endocrinology & Metabolism, City of Hope National Medical Center,
Duarte, CA: Insulin Metabolism and Chromium Nutrition.
Spr.'03 Nutrient Requirements & Functions Laboratory, USDA/BHNRC: Lisofylline, a Novel Anti-
Inflammatory Agent, Enhances Glucose-Stimulated Insulin Secretion in a Streptozotocin Rat Model of
Type-2 Diabetes Mellitus.
PUBLICATIONS:
1. Striffler, J.S. Biphasic insulin clearance by the liver in rat liver-pancreas preparations perfused in
situ: The effect of fasting. (Ph.D. Dissertation). Davis: University of California, 1977.
2. Striffler, J.S. and D.L. Curry. 1979. Rat liver-pancreas perfusion technique and metabolic functions.
Am. J. Physiol. 237 (4): E340-E348.
3. Striffler, J.S. and D.L. Curry. 1979. Effect of fasting on insulin removal by the liver of perfused
liver-pancreas. Am. J. Physiol. 237 (4): E349-E355.
4. Striffler, J.S. and D.L. Curry. 1980. Kinetics of insulin clearance by the liver in perfused liver-
pancreas. Endocr. Res. Commun. VII (4): 231-239.
5. Striffler, J.S., E.L. Cardell, and R.R. Cardell, Jr. 1981. Effects of glucagon on hepatic glycogen and

smooth endoplasmic reticulm. Am. J. Anat. 160 (4): 363-379.
6. Hammad, E.-S.F., J.S. Striffler, and R.R. Cardell, Jr. 1982. Morphological and biochemical
observations on hepatic glycogen metabolism in mice on a controlled feeding schedule. I. Normal
mice. Digestive. Diseases & Sciences. 26 (8): 680-691.
observations on hepatic glycogen metabolism in mice on a controlled feeding schedule. II.
Streptozotocin diabetic mice. Digestive Diseases & Sciences 27 (8): 692-700.
observations on hepatic glycogen metabolism in genetically diabetic (db/db) mice. Diabete and
Metabolisme 8 (2): 147-153.
9. Striffler, J.S., S.A. Garfield, E.L. Cardell, R.R. Cardell. 1984. Effects of glucagon on microsomal
glucose-6-phosphatase in vivo. Diabete and Metabolisme 10 (2): 91-97.
10. Striffler, J.S. 1985. Effect of a short term fast on hepatic microsomal glutathione-insulin
transhydrogenase. Diabete and Metabolisme 11(6): 368-375.
11. Striffler, J.S. 1987. Insulin clearance and microsomal glutathione-insulin transhydrogenase in
perfused livers of fed and fasted rats. Diabete and Metabolisme 13(6): 582-590.
12. Cornblath, D.R., M. Hillman, J.S. Striffler, C. Herman, and B.C. Hansen. 1989. Peripheral
neuropathy in diabetic monkeys. Diabetes 38: 1365-70.
13. Hansen, B.C., J.S. Striffler and N.L. Bodkin. 1993. Decreased hepatic insulin extraction precedes
overt non-insulin dependent (Type II) diabetes in obese monkeys. Obesity Research 1: 252-260.
14. Striffler, J.S., M.M. Polansky, and R.A. Anderson. 1993. Dietary chromium enhances insulin
secretion in perfused rat pancreas. J Trace Elements in Exp Med 6: 75-81.
15. Striffler, J.S., J.S. Law, M.M. Polansky, S.J. Bhathena and R.A. Anderson. 1995. Chromium
improves insulin response to glucose in rats. Metabolism 44: 1314-1320.
16. Velasquez, M.T., J.S. Striffler, A.A. Abraham, O.E. Michaelis IV, E. Scalbert, and N. Thiebault
1997. Perindopril ameliorates glomerular and renal tubulointerstitial injury in the SHR/N-corpulant rats
with Type II diabetes. Hypertension 30: 1232-1237.
17. Striffler, J.S., M.M. Polansky, and R.A. Anderson. 1998. Dietary chromium decreases insulin
resistance in rats fed a high fat mineral imbalanced diet. Metabolism 47: 1-4.
18. Striffler, J.S., S.J. Bhathena, O.E. Michaelis IV, J.D. Campbell, C.T. Hansen, E. Scalbert, N.
Thiebault, and M.T. Velasquez 1998. Long-term effects of perindopril on metabolic parameters and the
heart in the SHR/N-corpulant rat with NIDDM and hypertension. Metabolism 47: 1199-1204.
19. Velasquez M.T., Bhathena S. J., Striffler J. S., Thibault N., and E Scalbert. 1998. Role of

angiotensin-converting enzyme inhibition in glucose metabolism and renal injury in diabetes.
Metabolism 47: 7-11.
20. Striffler, J.S., M.M. Polansky, and R.A. Anderson. 1999. Overproduction of insulin in the
chromium (Cr) deficient rat. Metabolism 48: 1063-1068.
21. Striffler J.S. and Nadler J.L. 2004 Lisofylline, a novel anti-inflammatory agent,
enhances glucose-stimulated insulin secretion in vivo & in vitro: studies in pre-diabetic and normal
rats. Metabolism 53:290-296
22. Striffler, J.S., J.D. Campbell, R. Hussain and O.E. Michaelis IV. Longitudinal studies on beta cell
function and diabetic pathology in Wistar-Kyoto (WKY/NIH-CP) rats (in preparation).
23. Striffler, J.S., J.D. Campbell, C.T. Hansen, and O.E. Michaelis IV. Gender-related differences in
glucose tolerance and lipid responses in obese Wistar-Kyoto/NIH-Corpulant (WKY/N CP) rats.(in
preparation).
24. Striffler, J.S. and J.L. Nadler. Development of a Type-2 Rat Model of Diabetes Mellitus Using
Graded Doses of Streptozotocin (in preparation).
25. Striffler, J.S., M.M. Polansky and R.A. Anderson. 2007 Cinnamon administration enhances
glucose-induced insulin secretion in diabetic rats (in preparation).
ABSTRACTS AND PRESENTATIONS:
1. Striffler, J.S. and D.L. Curry. 1976. Biphasic insulin clearance by the liver in rat liver-pancreas
preparations perfused in situ. Endocrine Society 58th Annual Meeting. Abstract #66, p. 89 (slide
presentation).
2. Striffler, J.S., J.S. Stanley, and R.R. Cardell, Jr. 1979. Action of glucagon on hepatic smooth
endoplasmic reticulum and glycogenolysis in vivo. Endocrine Society 61st Annual Meeting. Abstract
#403, p. 1973.
3. Striffler, J.S., E.L. Cardell, and R.R. Cardell, Jr. 1980. Morphological effects of glucagon on hepatic
smooth endoplasmic reticulum (SER) and glycogen. Anat. Rec. 196: 183A (slide presentation).
4. Striffler, J.S., E.L. Cardell, and R.R. Cardell. 1981. Action of glucagon on hepatic SER and
glycogenolysis in vivo. Electron Microscopist's Society of the Ohio River Valley 3rd Meeting (slide
presentation).
5. Striffler, J.S., E.L. Cardell, and R.R. Cardell, Jr. 1981. Effects of glucagon on hepatic glucose-6-
phosphatase in vivo. Endocrine Society 63rd Annual Meeting. Abstract #1155, p. 371.
6. Striffler, J.S., F. Welborn, and R.R. Cardell, Jr. 1982. Early changes in portal blood glucose, insulin,
and glucagon during glucocorticoid-stimulated hepatic glycogen deposition in adrenalectomized rats.

Anat. Rec. 202: 182A.
7. Striffler, J.S., S.A. Garfield, and R.R. Cardell, Jr. 1982. Effects of glucagon on liver glycogen and
microsomal glucose-6-phosphatase in vivo. Endocrine Society 64th Annual Meeting. Abstract #348, p.
166.
8. Striffler, J.S. 1983. Insulin secretion in perfused pancreases of meal fed rats. Fed. Proc. 42: 587,
Abstract #1727 (slide presentation).
9. Striffler, J.S. 1984. The effect of a short-term fast on the latency of hepatic glutathione-insulin
transhydrogenase activity. Fed. Proc. 43: 524, Abstract #1400.
10. Striffler, J:S., S.A. Garfield, E.L. Cardell, and R.R. Cardell. 1984. Effects of glucagon on hepatic
glucose-6-phosphatase in vivo. Electron Microscopist's Society of the Ohio River Valley - Winter
Meeting (slide presentation).
11. Striffler, J.S. 1984. The effect of a short-term fast on the latency of hepatic glutathione-insulin
transhydrogenase activity in smooth and rough microsomes. Diabetes 33 (Supplement 1): 168A,
Abstract #643.
12. Striffler, J.S. 1985. Microsomal gluthathione-insulin transhydrogenase in perfused rat livers from
fed and fasted rats. Fed. Proc. 44: 435, Abstract #147 (slide presentation).
13. Striffler, J.S. and D.E. Link. 1985. Insulin metabolism in perfused livers of fed and fasted rats.
Endocrine Society 67th Annual Meeting. Abstract #105, p. 27.
14. Striffler, J.S. 1986. Clearance of insulin in perfused livers of fed and fasted rats. Fed. Proc. 45: 900,
Abstract #4338.
15. Striffler, J.S., N.L. Bodkin and B.C. Hansen. 1988. Insulin/Cpeptide levels in obese
hyperinsulinemic rhesus monkeys (macaca mulatta). FASEB J. 2: A1220, Abstract #5373.
16. Striffler, J.S., N.L. Bodkin, and B.C. Hansen. 1989. Reduced insulin clearance precedes onset of
overt type II diabetes in rhesus monkeys (macaca mulatta). FASEB J. 3: A929, Abstract #4084.
17. Bodkin, N.L., J.S. Striffler, H.K. Ortmeyer, and B.C. Hansen. 1989. Decreased hepatic insulin
extraction without change in hepatic glucose production in obese monkeys developing
hyperinsulinemia. Ann. Meeting, NASSO, Bethesda, MD.
18. Hansen, B.C., N.L. Bodkin, H.K. Ortmeyer, and J.S. Striffler. 1989. Reduced hepatic
insulin.extraction follows B-cell hypersecretion and precedes increased hepatic glucose production
during progression to diabetes (NIDDM). Diabetes 38: 222A, Abstract #845.
19. Cornblath, D.R., Hillman, M., Striffler, J.S. Herman, C., and B.C. Hansen. 1989. Peripheral
neuropathy in diabetic monkeys. Annals Neurol. 26: 184, Abstract, p. 87.
20. Striffler, J.S. and L.F. Berrio. 1990. Receptor-mediated clearance of insulin in perfused rat livers.

FASEB J. 4: A712, Abstract #2584.
21. Striffler, J.S., J. Law, M.M. Polansky, S. Bhathena and R.A.Anderson. 1992. Chromium decreases
insulin responses to glucose in rats. 74th Ann. Meeting of Endocrine Society, Abstract #1418, p. 406.
22. Striffler, J.S., M.M. Polansky, and R.A. Anderson. 1992. Dietary chromium improves IVGTT
insulin and glucose responses in sucrose fed chromium-deficient rats. FASEB J. 6: A2022, Abstract
#6285 (slide presentation).
23. Striffler, J.S., J.D. Campbell, and O.E. Michaelis IV. 1993. Gender-related differences in glucose
tolerance and lipid responses in obese Wistar-Kyoto/NIH-Corpulant (WKY/N-CP) rats. FASEB J. 7:
A606, Abstract #3511.
24. Michaelis IV, O.E., A.A. Abraham, C.T. Hansen, D.J. Sholfield, J.S. Striffler, and M.T. Velasquez.
1993. Development of a new strain of obese hyperinsulinemic salt-sensitive rat. FASEB J. 7: A270,
Abstract #1567.
25. Striffler, J.S., M.M. Polansky, and R.A. Anderson. 1993. Dietary chromium decreases insulin
resistance in rats. 75th Ann. Meeting of the Endocrine Society. Abstract #1500, p. 425.
26. Velasquez, M.T., J.S. Striffler, O.E. Michaelis IV, A.A. Abraham, E. Scalbert, N. Thiebault, and J.P
Bosch. 1993. ACE inhibition ameliorates glomerulosclerosis in the SHR/N-corpulant rat, a genetic
model of NIDDM and hypertension. 26th Ann. Meeting of the Am. Soc. of Nephrology, vol 4(#3), p.
806.
27. Striffler, J.S., M.M. Polansky, O.E. Michaelis IV, and R.A. Anderson. 1995. Expression of
chromium deficiency in rats may be related to dietary fat content. FASEB J. 9: A449, Abstract #2603.
28. Striffler, J.S., J.D. Campbell, and O.E. Michaelis IV. 1995. Evidence for abnormal beta cell
function in pancreas of the Wistar-Kyoto/N-cp strain rat. 77th Ann. Meeting of the Endocrine Society.
Abstract #P1252, p. 175.
29. Rago, Zs, J.S., Striffler, A.A. Abraham, O.E: Michaelis IV, E. Scalbert, N. Thiebault, and
M.T.Velasquez. 1996. Expression of TGF-B is elevated in the renal cortex of the SHR/N-corpulant rats
with diabetic nephropathy. 11th Ann. Meeting of the Am. Soc. of Hypertension.
30. Velasquez, M.T., A.A. Abraham, and J.S. Striffler. 1998. Differential renal expression of TGF-Beta
isoforms in the SHR/N-corpulant rat with diabetic nephropathy. 13th Ann. Meeting of the Am. Soc. of
Hypertension.
31. Striffler, J.S., M.M Polansky, R.AAnderson. 1998 Overproduction of insulin in the chromium (Cr)
deficient rat. Intl Symposium on the Health Effects of Dietary Chromium, Dedham, MA. May 1-2.
32. Striffler, J.S and J.L Nadler. 2000 Lisofylline, a novel modulator of fatty acid metabolism, improves
insulin secretion in a model of type 2 diabetes. FASEB J 14:
33. Prasad, K-M., Striffler, J.S., and J.L. Nadler. 2000 Evidence that increased 12-lipoxygenase

expression in pancreatic beta cells induces apoptosis and insulin secretory dysfunction. 82nd Ann
Meeting of the Endocrine Society. Abstract #278, p. 76.
34. Striffler, J.S. and J.L. Nadler. 2000 Lisofylline (LSF), a novel modulator of fatty acid metabolism,
improves insulin secretion and glucose tolerance in a rat model of type 2 diabetes mellitus (DM). 82nd
Ann Meeting of the Endocrine Society. Abstract #320, p. 57.
35. Striffler, J.S. and J.L. Nadler. 2001 Lisofylline, a novel modulator of fatty acid metabolism,
enhances glucose-stimulated insulin release in perfused pancreata from normal rats. Diabetes 51:
A362, Abstract #1505-P.
36. Striffler, J.S. and J.L Nadler. 2003 Lisofylline, a new anti-inflammatory agent, improves
nephropathy in streptozotocin diabetic rats. 85th Ann Meeting of the Endocrine Society. Abstract #P1-
308, p. 206.
37. Striffler, J.S., M.M. Polansky and R.A. Anderson. 2007 Cinnamon administration enhances
glucose-induced insulin secretion in diabetic rats. FASEB J 21: Abstract #299.
38. Striffler, J.S. & Anderson R.A. 2008 Development of a Streptozotocin Diabetic Rat Model for
Studies on the Effects of Cinnamon on Diabetes.

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