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VARIABILITY OF ENTROPY AS AN INDICATOR FOR STABILITY OF ANAESTHESIA DEPTH DURING IN VITRO FERTILIZATION PROCEDURES
1. WCA 2016 - Abstract Submission
Topic: Obstetric
WCA16-ABS-1514
VARIABILITY OF ENTROPY AS AN INDICATOR FOR STABILITY OF ANAESTHESIA DEPTH
DURING IN VITRO FERTILIZATION PROCEDURES
Vera Potievskaya* 1, Igor Ushakov2
1Anaesthesiology and Intensive Care, Russian Medical Academy for Postgraduate Training, 2Anaesthesiology , Clinical
hospital Moskvorechye, Moscow, Russian Federation
Preferred presentation method: e-Poster or oral communication
I confirm that I fulfill eligibility criteria and that I wish to apply for a travel bursary: No
Do yo wish to submit a case study or research abstract?: Research abstract
Background & Objectives: It has been shown that entropy monitoring allows to assess depth of anaesthesia and
improves anaesthesia awareness [1, 2]. Usually response entropy (RE) and state entropy (SE) are measured. We
suggested a new calculated parameter - variability of entropy (VE) to evaluate stability of anaesthesia. The objective of
the study was to compare stability of intravenous propofol and volatile sevoflurane anaesthesia during oocytes retrieval
by VE assessment.
Materials & Methods: 26 women of ASA physical status I scheduled for oocytes retrieval were randomized into two
groups. Induction of anaesthesia was performed with sevoflurane (group 1) or intravenous intermittent propofol boluses
(group 2). RE and SE were recorded, VE was calculated as RE-SE/SE×100%. We compared results in the two groups
during periods of induction, time of oocyte retrieval (intervention) and awake. Data were presented as median [25%; 75%
interquartile ranges], Mann-Whitney test was applied.
Results: In all patients RE and SE values decreased during all periods that reflected adequate depth of anaesthesia and
did not significantly differ between groups. VE was higher in the group of propofol comparing with sevoflurane during
periods of oocyte retrieval (p<0.05), but there was no significant difference in the period of induction and awakening
period between two groups (table). This fact may reflect analgesics effect of sevoflurane because of lower RE values.
Table.
Variability of entropy during sevoflurane and propofol anaesthesia.
Variables Sevoflurane Propofol P
VE baseline, % 10,1[10; 12,9] 10,1 [8,8; 11,4] 0,89
VE induction, % 5,2 [1,2; 21,4] 39,1 [6,2; 26,4] 0,34
VE intervention, % 0 [0; 4,8] 16,6 [0; 20] 0,02
VE awake, % 10,5 [8,7; 15,1] 10,5 [9,2; 12,6] 0,98
Conclusion: Assessment of variability of entropy in addition to RE and SE allows not only detect the depth of
anaesthesia, but also more clearly evaluate its stability and balance of hypnotic and analgesic effects. Use of volatile
anaesthetic sevoflurane during oocytes retrieval demonstrated more stable anaesthesia level than propofol.
References: 1. Bein B. "Entropy". Best practice&research clinical anesthesiology 2006, 20 (1): 101-109. 2. Gao JD, Zhao
YJ, Xu CS, Zhao J et al. "Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a
multicenter clinical trial". Chin Med J (Engl), 2012, 125 (8): 1389–92.
Disclosure of Interest: None declared
![WCA 2016 - Abstract Submission
Topic: Obstetric
WCA16-ABS-1514
VARIABILITY OF ENTROPY AS AN INDICATOR FOR STABILITY OF ANAESTHESIA DEPTH
DURING IN VITRO FERTILIZATION PROCEDURES
Vera Potievskaya* 1, Igor Ushakov2
1Anaesthesiology and Intensive Care, Russian Medical Academy for Postgraduate Training, 2Anaesthesiology , Clinical
hospital Moskvorechye, Moscow, Russian Federation
Preferred presentation method: e-Poster or oral communication
I confirm that I fulfill eligibility criteria and that I wish to apply for a travel bursary: No
Do yo wish to submit a case study or research abstract?: Research abstract
Background & Objectives: It has been shown that entropy monitoring allows to assess depth of anaesthesia and
improves anaesthesia awareness [1, 2]. Usually response entropy (RE) and state entropy (SE) are measured. We
suggested a new calculated parameter - variability of entropy (VE) to evaluate stability of anaesthesia. The objective of
the study was to compare stability of intravenous propofol and volatile sevoflurane anaesthesia during oocytes retrieval
by VE assessment.
Materials & Methods: 26 women of ASA physical status I scheduled for oocytes retrieval were randomized into two
groups. Induction of anaesthesia was performed with sevoflurane (group 1) or intravenous intermittent propofol boluses
(group 2). RE and SE were recorded, VE was calculated as RE-SE/SE×100%. We compared results in the two groups
during periods of induction, time of oocyte retrieval (intervention) and awake. Data were presented as median [25%; 75%
interquartile ranges], Mann-Whitney test was applied.
Results: In all patients RE and SE values decreased during all periods that reflected adequate depth of anaesthesia and
did not significantly differ between groups. VE was higher in the group of propofol comparing with sevoflurane during
periods of oocyte retrieval (p<0.05), but there was no significant difference in the period of induction and awakening
period between two groups (table). This fact may reflect analgesics effect of sevoflurane because of lower RE values.
Table.
Variability of entropy during sevoflurane and propofol anaesthesia.
Variables Sevoflurane Propofol P
VE baseline, % 10,1[10; 12,9] 10,1 [8,8; 11,4] 0,89
VE induction, % 5,2 [1,2; 21,4] 39,1 [6,2; 26,4] 0,34
VE intervention, % 0 [0; 4,8] 16,6 [0; 20] 0,02
VE awake, % 10,5 [8,7; 15,1] 10,5 [9,2; 12,6] 0,98
Conclusion: Assessment of variability of entropy in addition to RE and SE allows not only detect the depth of
anaesthesia, but also more clearly evaluate its stability and balance of hypnotic and analgesic effects. Use of volatile
anaesthetic sevoflurane during oocytes retrieval demonstrated more stable anaesthesia level than propofol.
References: 1. Bein B. "Entropy". Best practice&research clinical anesthesiology 2006, 20 (1): 101-109. 2. Gao JD, Zhao
YJ, Xu CS, Zhao J et al. "Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a
multicenter clinical trial". Chin Med J (Engl), 2012, 125 (8): 1389–92.
Disclosure of Interest: None declared](https://image.slidesharecdn.com/wca16-abs-1514-preview-1-160912085431/85/VARIABILITY-OF-ENTROPY-AS-AN-INDICATOR-FOR-STABILITY-OF-ANAESTHESIA-DEPTH-DURING-IN-VITRO-FERTILIZATION-PROCEDURES-1-320.jpg)
