2. CAR-T: Market Positioning
2
The purpose of this presentation is
to examine the CAR-T market
landscape with an eye on brand
positioning, market messaging and
current external perceptions.
The contents include a high level
overview of the nomenclature and
nascent brand architecture of the
primary companies, a review of the
evolving CAR-T lexicon, and the
results of a CAR-T specific Brand
Equity Perception Study conducted
in March, 2015.
Differentiation Dimensions
Overview:
The CAR-T
Nomenclature and
Nascent Brand
Architecture
Brand Acumen’s
CAR-T
Brand Equity
Perception Study
March, 2015
A Review of the
Evolving
CAR-T Lexicon
5. SurveyDesign
5
To initiate the CAR-T Brand Equity
Study we surveyed five segments
of Key Innovation Leaders (KILs).
• Bio Industry Writers (8)
• Venture Capitalists (7)
• Oncologists (35)
• CAR-T Specific Researchers (21)
• Market Makers/Analysts (12)
CAR-TBrandEquityPerceptionStudy
Brand Acumen’s CAR-T Brand Equity survey methodology brings together market,
brand, competitive, and technological attribute perceptions.
A corporate brand’s performance can be assessed allowing for a roadmap for
improvement to be identified in micro-niche biotech ecosystems.
samplesize/
numberofrespondents
Each of the six attribute
categories are scored from
0-100 with 0 being the lowest
and 100 the highest score.
The scores are weighted
based on respondents
answers to quantitative and
qualitative criteria.
6. chimeric antigen receptor therapy
CAR-T:
The Main Players
A Review of Company Nomenclature and
Results of the Brand Acumen CAR-T Brand Equity Perception Study
7. 7
CAR-T
nomenclature
@NascentCAR-TNomenclature
tisagenlecleucel-T
Alternative Names:
• Anti-CD19-CAR retroviral vector-transduced autologous T
cells - University of Pennsylvania
• Anti-CD19-CAR transduced T cells - Novartis/University of
Pennsylvania
• CART-019; CART-19; CART-19 cells
• Chimeric antigen receptor-modified T cells against CD19 -
University of Pennsylvania/Novartis
• CTL 019
• LG-740
Most Recent Events
26 Feb 2015
Phase-II clinical trials in
Diffuse large B cell lymphoma
in USA (IV) (Novartis, pipeline,
February 2015)
08 Dec 2014 Efficacy data from
a pediatric study in Acute
lymphoblastic leukemia
presented at the 56th Annual
Meeting and Exposition of the
American Society of
Hematology (ASH-Hem-2014)
15 Oct 2014 Interim efficacy
and adverse events data from
two phase I trials in Acute
lymphoblastic leukemia
(second-line therapy or
greater) released by University
of Pennsylvania
tisa – gen – lec – leu – cel - T
generic name
• MesoCART
• huCART19
non-proprietary name
CRISPR/Cas9
9. CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
12. CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
15. CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
18. CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
21. CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
24. CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
27. CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.