The document discusses a novel stem cell therapy developed by the National Children's Leukemia Foundation (NCLF) for treating leukemia and cancer. Called the "Stem Cell Cocktail", it involves targeting multiple molecular pathways that regulate cancer cell growth using a combination of stem cell compounds. In vitro and in vivo studies show the therapy is effective at inhibiting leukemia cell growth and increasing survival in animal models. The NCLF aims to further test additional combinations and expand the approach to other cancer types with the goal of bringing this potential cure to clinical trials.

1. Providing the Cure
GIL 2012: RUSSIA
The Global Community of Growth, Innovation and Leadership
A Novel Therapy for the Treatment of
Leukemia and Cancer
“The Stem-Cell Cocktail”
Steve Shor Brian Denker
Founder & Executive Director Vice President & Global Head
NCLF Cancer Research Center Growth, Innovation and Leadership
Frost & Sullivan
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org

2. Providing the Cure
Why is cancer so challenging?
 Cancer is dynamic & adaptive.
 Cancer is strong & resilient.
 Cancer is complex & innovative.
 Cancer is opportunistic.
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org

3. Providing the Cure
The Typical Question: The BIG Question…
In what ways does the The NCLF Question
typical cancer cell differ
• What are the mechanisms that
from the normal cell?
foster growth in cancer cells?
• Are there multiple pathways of
growth?
• How does the cancer cell
harness the energy of the human
body to facilitate growth?
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org

4. Providing the Cure
NCLF Bio Medical Research Center
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org

5. Cancer/Leukemia cells Providing the Cure
The Stem Cell & Cancer
Interaction Paradigm
Molecular pathways analysis
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te
Adult Stem Cells

6. Providing the Cure
Unleashing the Potential of Stem Cells
in Cancer Therapy
Cancer -Stem cell Interaction Paradigm
Identify target molecular pathways
regulating cancer cell growth & development
Design of interventions using
multiple target molecular pathways
Addressing the complexity of
cancer development and diversity
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org

7. Providing the Cure
Combination Therapy Approach
Pathway
#1
Pathway
#3
Pathway #2
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org

8. Providing the Cure
Stem Cells
• Multiple Pathways
Compound
#2
• Multiple Targets
• Multiple Compounds
Compound
#3
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org

9. Providing the Cure
Growth Inhibition of Leukemia Cells using
“Stem Cell Cocktail” Therapy
Growth inhibition of Leukemia cells after 72h of culture
Viable cell number (OD)
1.8
1.75
1.7
(in vitro results)
1.65
1.6
1.55
1.5
1.45
1.4
1.35
1.3
A
B
C
)
l
ro
+C
d
d
d
nt
un
un
un
+B
Co
po
po
po
(A
m
m
m
l"
Co
Co
Co
ai
kt
oc
"C
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org

10. Providing the Cure
“Stem Cell Cocktail”
A Therapy to Treat Cancer
(in vivo results)
Survival of Leukemia harboring animals treated with Adult stem cells
1.1
1.0 control
0.9 SC treated
Fraction survival
0.8
0.7 P<0.0001
0.6
0.5
0.4
0.3
0.2
0.1
0.0
0 10 20 30 40 50 60 70
In S t rate gi c P art n e rs h i p wi th :
Days
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org

11. Providing the Cure
A Cure IS POSSIBLE in our Generation
National Children’s Leukemia Foundation
Use of Mesenchymal Stem Cells
for the Treatment of Leukemia
United States Provisional Patent Application #61/564,317
November 29, 2011
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org

12. Providing the Cure
Trajectory of Progress
Clinical Trials
Pre-Clinical Trials
*Testing Additional Combinations
*Creating additional “Cocktails”
*Expanding the paradigm to
other cancer types.
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org

13. Providing the Cure
The Cure IS Within Our Reach
• Explore these advancements in cancer
research further, be apart of it.
• Determine how you too can help
NCLF to contribute to these
advancements.
• Make a Difference – Find your
visionary innovation, support each
other, members of the GIL
Community and it’s global partners
contributing and changing the world.
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org

14. GIL 2012: Beyond the Journey to Visionary Innovation
Next Steps
Share, Engage and Inspire 24x365 Schedule a one-on-one Develop Your Visionary and Innovative Skills
via the online GIL Community Growth Strategic Dialogue Growth Partnership Service
Leverage the GTL in your monthly Envision Your Future and Succeed Get Your Entire Team Innovating to Zero
GIL Community Newsletter (GCN) with Growth Workshops with an on-site Mega Trends Workshop