1.
CANCER BIOLOGY
Research Advocacy Training and Support Program
Our webinar will begin shortly.
WELCOME!

2.
• Speaker(s): Dan A. Dixon, PhD and Nancy Roach, Fight CRC
Founder and Cancer Advocate
• Archived Webinars: FightColorectalCancer.org/Webinars
• AFTER THE WEBINAR: Expect an email with links to the material &
a survey. If you fill it out, we’ll send you a Blue Star pin.
• Ask a question in the panel on the RIGHT SIDE of your screen
• Follow along via Twitter – use the hashtag #CRCWebinar
Today’s Webinar:

3.
What is a RESEARCH ADVOCATE?
A research advocate brings the patient viewpoint to the
research process and communicates a collective patient
perspective.
Fight CRC’s Research Advocacy Training and
Support (RATS) Program:
Goal: to improve the ability of research advocates to
effectively participate in the research process.
This is done by hosting person meetings, online
trainings, and webinars, in addition to ongoing support.
Brought to you by
RATS:

4.
Resources:

5.
Disclaimer
:
The information and services provided by Fight Colorectal Cancer are for
general informational purposes only. The information and services are
not intended to be substitutes for professional medical advice, diagnoses
or treatment.
If you are ill, or suspect that you are ill, see a doctor immediately. In an
emergency, call 911 or go to the nearest emergency room.
Fight Colorectal Cancer never recommends or endorses any specific
physicians, products or treatments for any condition.

6.
Goals
for
today
– Gain
a
basic
understanding
of
normal
cell
biology
and
what
makes
cancer
happen.
– Get
a
feel
for
some
of
the
language
and
process
of
basic
research.
– Understand
some
of
the
questions
that
need
to
be
answered
in
order
to
move
the
field
forward.
– Feel
more
comfortable
with
being
overwhelmed
by
scientific
language.

7.
DoD
grant

8.
Dan
Dixon
&
Nancy
Roach
Fight CRC Founder & Chair of the BoardCo-­Leader: Cancer Prevention & Survivorship
Univ. of Kansas NCI-­Designated Cancer Center

9.
Cell
Structure

10.
Cells,
genes
and
signaling
pathways

11.
Cell
Communication
http://sciencedoing.blogspot.com/2012/10/cell-­‐receptors-­‐2012.html
Cell
membrane
Signaling
pathway
Signal
transduction

12.
Review!
• We
are
made
of
cells.
• Genes
control
what
cells
do.
• Signaling
pathways
inside
of
cells
tell
the
genes
what
to
do.
• Signal
transduction
is
the
process
of
cells
talking
and
listening
to
each
other.
• Ligands
are
the
molecules
that
float
around
outside
cells
(signal
transduction!).
• Receptors
are
the
proteins
that
stick
outside
of
cells
and
grab
the
ligands
(signaling
pathways!).

13.
Normal
colon
stem
cells

14.
Cancer
Stem
Cell

15.
Normal Colon
(colonscopy)
Colorectal Cancer (CRC)

16.
TIME!

17.
Review!
• Our
bodies
are
very
complicated
collections
of
cells
that
interact
in
a
controlled,
balanced
way.
• Cell
growth
is
usually
controlled
by
genes
and
the
signals
they
send
out
BUT…
• If
mutations
of
key
genes
occur,
cell
growth
can
go
out
of
control
and
lead
to
cancer.

18.
VOCABULARY!
• Oncogenes
• Tumor
suppressor
genes
–Apoptosis
• DNA
repair
genes

19.
Growth
Control
Signaling
Pathway
Note:
Growth
Factors
are
LIGANDS

20.
Normal
Stage
0
Stage
1
– 2
Stage
2
– 3
Stage
4

21.
Mutations
in
Colorectal
Cancer
Oncogenes
and
Tumor
Promoters Tumor
Suppressors

22.
Review
• Oncogenes: accelerator
on.
• Tumor
suppressor
genes: brakes
off.
• DNA
repair
genes: sensors
and
mechanic
don’t
work.
• Cancer
involves
multiple
mutations
over
time
in
order
to
overcome
our
natural
defenses.

23.
Why
Cancer
Biology
Is
Important

24.
Question & Answer:
SNAPA
#STRONGARMSELFIE
Bayer HealthCare will donate $1 for every photo
posted (up to $25,000).
Flex a “strong arm” & post it to Twitter or
Instagram! (Use the hashtag!)