3. DPCP
• Clinical efficacy of diphenylcyclopropenone in
alopecia areata: Retrospective data analysis of
50 patients
• JAAD september 2014
4.
5. How to apply
• Test patch of 2% left for 2-3 days
• Treatment each week of escalating doses of
0.001%, 0.01%,0.05%,0.1%,0.5%,1%,2%
• Each time, max of 1ml of DPCP used, and left
on scalp for 6-24 hours
• No sun exposure of the area for 24 hours, as
sunlight degrades DPCP
• Safe in children, no proper studies in pregnant
women
6.
7. Pulsed oral steroid therapy
• A systematic review of pulse steroid therapy
for alopecia areata
• JAAD february 2016
• Compared efficacy of PO steroids daily vs.
once weekly
8. Statins
• Simvastatin/ezetimibe
• Two different studies done:
• Vytorin, Merck and Co, Kenilworth, published in JAAD
May 2015: group of 17 patients with severe alopecia
areata poor/no response
• Lattouf et al, published in issue 72 of JAAD in 2015: 19
patients with mild/moderate alopecia areata good
response in 14 out of 19 patient
• Conclusion statins may be a treatment options for
patients with mild/moderate AA
9.
10.
11.
12. Prostaglandin 2a analogues
• Ross EK, Bolduc C, Lui H, Shapiro (Acad Dermatol.
2005;53(6):1095-1096) Lack of efficacy of topical
latanoprost in the treatment of eyebrow alopecia areata
• Faghihi G, Andalib F, Asilian A (Eur J Dermatol.
2009;19(6):586-587) Lack of efficacy of topical
latanoprost in the treatment of eyebrow alopecia areata
• Roseborough I, Lee H, Chwalek J, Stamper RL, Price VH. (J
Am Acad Dermatol. 2009;60(4):705-706) Lack of efficacy
of topical latanoprost and bimatoprost ophthalmic
solutions in promoting eyelash growth in patients with
alopecia areata.
13. Or is it?
• Vila TO, Camacho Martinez FM. Int J Trichology. 2010;
2(2:)86-88. out of 37 patients with AAU: 24.32%
achieved complete eyelash regrowth, 18.91% achieved
moderate regrowth, 27.02% achieved slight growth,
and 29.72% achieved no growth BUT patients were
also treated with intralesional triamcinolone in scalp
and eyebrows Q3/12
• Coronel-Perez IM, Rodrıguez-Rey EM, Camacho-
Martınez FM. J Eur Acad Dermatol Venereol.
2010;24(4) higher rates of eyelash regrowth in
patients on triamcinolone+lanatoprost compared to
triamcinolone alone
14. Azathioprine
• Treatment of recalcitrant adult alopecia areata
universalis with oral azathioprine
• JAAD 2015, Issue 75
• 14 patients, all with AAU not responding to
corticosteroids
• 2.5mg/kg daily
• 6 out of 14 showed response, 4 with
persistent response after discontinuation
