Does native Con A exist as a monomer, dimer, trimer, or tetramer? Does native Con A exist as a monomer, dimer, trimer, or tetramer? Solution At pH=5, the Concanavalin exists as dimer. At pH= 5, Con A exists as three dimeric types are possible: Homologous dimers of either 2 intact or 2 fragmented monomer units and a hybrid dimer consisting of one monomer of each form. Binding results indicate: a. That a mixture of dimeric types must bind at pH=5, some types having one binding sites per molecule; b. That species must have similar affinity for ligand..

1. Does native Con A exist as a monomer, dimer, trimer, or tetramer?
Does native Con A exist as a monomer, dimer, trimer, or tetramer?
Solution
At pH=5, the Concanavalin exists as dimer. At pH= 5, Con A exists as three dimeric types are
possible: Homologous dimers of either 2 intact or 2 fragmented monomer units and a hybrid
dimer consisting of one monomer of each form. Binding results indicate:
a. That a mixture of dimeric types must bind at pH=5, some types having one binding sites per
molecule;
b. That species must have similar affinity for ligand.