If you are talking about an extraction design, the the water solubility has to be greater in the aqueous base because of the greater solubility of the salts of the acids (with few exceptions), again presuming a differential extraction aqueous to organic. Solution If you are talking about an extraction design, the the water solubility has to be greater in the aqueous base because of the greater solubility of the salts of the acids (with few exceptions), again presuming a differential extraction aqueous to organic..