1) a.Seasonal H1N1 influenza: Seasonal contaminate the superior or upper respiratory. b. Pandemic H1N1 influenza strain infect: Pandemic contaminate bottom or lower respiratory tract. 2) 2-3 Alpha related to sialic acid and it vary from 2-6 related to sialic acid. 3) a.Moderate change of the virus eg: infecting the flu many times in one year in seasonal H1N1 influenza b.sudden paramount change occurs of virus in pandemic H1N1 influenza. Solution 1) a.Seasonal H1N1 influenza: Seasonal contaminate the superior or upper respiratory. b. Pandemic H1N1 influenza strain infect: Pandemic contaminate bottom or lower respiratory tract. 2) 2-3 Alpha related to sialic acid and it vary from 2-6 related to sialic acid. 3) a.Moderate change of the virus eg: infecting the flu many times in one year in seasonal H1N1 influenza b.sudden paramount change occurs of virus in pandemic H1N1 influenza..