Identify the ways in which neutrophils can destroy microbial Identify the ways in which neutrophils can destroy microbial invaders. They may engulf and destroy invaders using their destructive enzymes and antimicrobial substances. They may release toxins that kill host cells so microbes have nowhere to go. They may degranulate to release their granules and DNA to generate a NET for microbe destruction. They may release toxins that kill host cells so microbes have nowhere to go. They may degranulate to release their granules and DNA to generate a NET for microbe destruction. They may release reactive oxygen species into the tissue to kill host and thus microbial cells. They may release antibodies that bind to and tag microbes for destruction by other leukocytes..