Thyroid development, physiology and hypothyroidism
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Hypothyroidism in children
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Thyroid development, physiology and hypothyroidism
- 61. AGE DOSE (MICROGM/KG/DAY) 1-3 YRS 4-6 3-10 YRS 3-5 10-16 2-4
Editor's Notes
- Parathyroid – chief cells and oxyphil cells. Parathromone – blood calcium level
- Thyroid peroxidase Only 20% of circulating T3 is secreted by thyroid The rest is formed by deiodination of T4 in target tisues- liver kidney In brain about 80% T3 is prodced from T4
- TSH – 5 months -20 yrs – 0.5-5.5 mIU/l
- TBG – thyroid binding globulin
- The thyroid gland is part of the hypothalamic-pituitary-thyroid axis, and control of thyroid hormone secretion is exerted by classical negative feedback, as depicted in the diagram. Thyroid-releasing hormone (TRH) from the hypothalamus stimulates TSH from the pituitary, which stimulates thyroid hormone release. As blood concentrations of thyroid hormones increase, they inhibit both TSH and TRH, leading to "shutdown" of thyroid epithelial cells. Later, when blood levels of thyroid hormone have decayed, the negative feedback signal fades, and the system wakes up again.
- Depth of respiration - hypepnea
- Transcription factors
- Details about goitre
- Chloride iodine channel is common to both cochlea and thyroid
- AF – PF
- Beta carotene levels increased Anorexia hypothyroidism
- Free t4 and free t3 Heel prick – Guthrie test – galactossemia, maple syrup, phenylketonuria
- Wormian bones, also known as intra sutural bones,[1] are extra bone pieces that occur within a suture (joint) in the cranium. Lambdoid suture Rickets, osteogenesis, hypothyroididm
- so t3 and t4 become normal with levothyroxine alone. T4 tablet strength -
- Menometrorrhagia is a condition in which prolonged or excessive uterine bleeding occurs irregularly and more frequently than normal. It is thus a combination of metrorrhagia and menorrhagia. Menorrhagia is a menstrual period with excessively heavy flow and falls under the larger category of abnormal uterine bleeding (AUB).[1]
- Nodule – non teder, firm and rubbery consistency