Recommended
More Related Content
What's hot
What's hot (20)
Similar to Antipsychotic drugs by dr nadira sultana
Similar to Antipsychotic drugs by dr nadira sultana (20)
Recently uploaded
Recently uploaded (20)
Antipsychotic drugs by dr nadira sultana
- 1. BY DR. NADIRA SULTANA PHARM.D ANTIPSYCHOTIC DRUGS
- 2. Antipsychotic drugs are used for treating major psychosis. They are also called as “ major tranquilizers” since they reduce agitation and disturbed behaviour in schizophrenia.
- 3. CLASSIFICATION OF DRUGS phenothiazines Chlorpromazine triflupromazine fluphenazine thioridane butyrophenones haloperido;l trifluperidol thioxanthines flupenthixol miscellaneous Oxypertine tetrabenzine pimozide penfluridol Atypical antipsychotics Clozapine risperidone olanzepine
- 4. PHENOTHIZINES Are three ringed structures, in which benzene ring are linked by sulphur and nitrogen atom. Chlorpromazine is imp phenothiazines. Pharmacological action CNS: a) psychomotor slowing b) emotional quietening c)decreased initiative d) decreased anxiety do not have analgesic and anticonvulsant effect but they potentiate analgesic effect of morphine.
- 5. ANTIEMETIC EFFECT Has powerful antiemetic effect produced by depressing CTZ. ANS: has an alpha adrenergic blocking effect . It also blocks the action of ACH and 5- hydroxytryptamine. CVS: has hypotensive, myocardial depressant and anti fibrillatory effect. endocrine system: in females, it produces ovulation , amenorrhea, lactation . In males , it produces loss of libido. These effect are produced by blocking the action of dopamine on hypothalamus and pituitary.
- 6. MISCELLANEOUS Inhibition of hicoughs Local analgesic effect Skeletal muscle relaxant effect Absorption , fate, excretion: Well absorb orally and parenteral. High conc is found in lungs, liver and adrenal glands Enterohepatic circulation Increases its duration of action Metabolised in liver Excrete in urine
- 7. ADR CNS: drowsiness, excitement, psychotic rcn, confusion, parkinsonism. ANS EFFECT: blurred vision, tachycardia, constipation . due to anti cholinergic effect. Extrapyramidal symptoms of parkinsonism like tremor, muscular rigidity Hemopoietic effect: agranulocytosis, thrombocytopenia, aplastic anemia. Endocrine : menstural disturbances Intolerance: skin eruptions, photosensitivity, dermatitis, cholestatic jaundice.
- 8. DOSE AND PREPARTION: 1) chlorpromazine tablets and syrup: 25-100mg by mouth 2) chorpromazine inj: 25-5mg by i.m inj. Uses treat major psychosis to control agrressiveness in children antiemetic treat hicough pre aneasthetic medication
- 9. HALOPERIDOL It produce more sedative and autonomic effect than chlorpromazine Dose: 1.5-4.5mgTID PIMOZIDE AND PENFLURIDOL both are diphenylbutyl piperidines. long duration of action . Single dose is sufficient to treat pt Atypical antipsychotic 1) extrapyramidal effect are less, safety is more. 2) Imprve negative symptoms. 3)not elevate serum prolactin level 4)do not produce catalepsy in animals
- 10. CLOZAPINE It is an atypical antipsychotic whichdoes not produce extrapyramidal symptoms. It has anti adrenergic ,antimuscarinic, antihistamine and anti 5HT effect ADR: agranulocytosis Use: it is reserve drug in schizophrenia
- 11. RISPERIDONE Atypical antipsychotic It is a benzisoxazole Effect similar to clozapine. It blocks adrenergic alpha1 and alpha2, histamine and 5HT receptors Less extrapyramidal effect
- 12. OLANZEPINE Atypical antipsychotic Dibenzodiazepine compound It does not antagonise alpha2 receptor function It does not produce extrapyramidal symptoms It does not produce agranulocytosis.it is an advantage over clozapine ADR: dry mouth , sedation, nausea, weight gain.
- 13. THANK YOU