3. DEFINITIONS
Acute renal failure is a sudden reduction in
kidney function that results in nitrogenous
wastes accumulating in the blood.
ARF is an abrupt decline in glomerular and
tubular function, resulting in the failure of the
kidneys to excrete nitrogenous waste products
and to maintain fluid and electrolyte
homeostasis.
4. Acute renal failure (ARF) refers to a sudden
and usually reversible loss of renal function,
which develops over a period of days or weeks
and is usually accompanied by a reduction in
urine volume.
6. ETIOLOGY
There are many possible causes and it is frequently
multifactorial. The clinical picture is often dominated by
the underlying condition (e.g. septic shock, trauma). If
the cause cannot be rapidly corrected and renal
function restored, temporary renal replacement therapy
may be required.
The causes can be:
I. PRE-RENAL 55-60%
II. POST RENAL <5%
III. RENAL 35-40%
7.
8. Prerenal causes
Most common cause of ARF
Problems affecting the flow of blood before it reaches
the kidneys
1. Intravascular volume depletion (dehydration)
– Hemorrhage
– Vomiting, diarrhea
– “Third spacing”
– Diuretics
9. 2. Disruption of blood flow to the kidneys .
Major surgery with blood loss, severe injury or burns, or
infection in the bloodstream.
Blockage or narrowing of a blood vessel carrying blood to
the kidneys.
Heart failure or heart attacks causing low blood flow.
Liver failure causing changes in hormones that affect blood
flow and pressure to the kidney.
11. Post renal
Problems affecting the movement of urine out
of the kidneys.
a) Kidney stone: usually only on one side.
b) Cancer of the urinary tract organs or structures
near the urinary tract that may obstruct the
outflow of urine.
c) Medications.
12. d) Bladder stone.
e) Benign prostate hyperplasia (the most
common cause in men).
f) Blood clot.
g)Bladder cancer.
Must be bilateral to result in ARF
– Unless : single kidney or prior chronic renal failure
13. Suspect obstruction in anuria
Etiology may be age dependent
– Young = congenital abnormality
– Older male = prostatic enlargement
ARF most often associated with lesions in:
– Bladder, prostate or urethra
14.
15. Intrinsic (renal) ARF
Renal Problems with the kidney itself
that prevent proper filtration of blood
or production of urine, those include:
1. Tubular (ATN)
2. Interstitial (AIN)
3. Glomerular (Glomerulonephritis)
4. Vascular
25. Risk Factors of contrast-induced ARF
Renal insufficiency
Diabetes mellitus
Multiple myeloma
High osmolar (ionic) contrast media
Contrast medium volume
26. Clinical Characteristics
Onset - 24 to 48 hrs. after exposure
Duration - 5 to 7 days
Non-oliguric (majority)
Dialysis - rarely needed
Urinary sediment - variable
Low fractional excretion of Na
27. Prophylactic Strategies
Use I.V. contrast only when necessary
Hydration
Minimize contrast volume
Low-osmolar (nonionic) contrast media
N-acetylcysteine, fenoldopam
28. RISK FACTORS
Advanced age
Blockages in the blood vessels in your arms or
legs
Diabetes
High blood pressure
Heart failure
Kidney diseases
Liver disease
29. Common clinical features of ARF
Azotemia “Is a medical condition characterized by abnormally high levels of
nitrogen-containing compounds (such as urea, creatinine, various body waste compounds,
and other nitrogen-rich compounds) in the blood.”
Hypervolemia
Electrolytes abnormalities:
Increase K+ & phosphate
Na+ & calcium
Metabolic acidosis
Hypertension
Oliguria - anuria
30. Weight loss.
Nocturnal urination.
pale urine.
Less frequent urination, or in smaller amounts than usual, with
dark coloured urine
Bone damage.
Non-union in broken bones.
Muscle cramps (caused by low levels of calcium which can cause
hypocalcaemia).:
Abnormal heart rhythms.
Muscle paralysis.
38. Distinguishing tubulo-interstitial disease
from Pre-Renal ARF
Most difficult classification of ARF
Urine sediment helpful
(i) Bland
Pre-renal azotemia
Urinary outlet obstruction
(ii) RBC casts or dysmorphic RBCs
Acute glomerulonephritis
Small vessel vasculitis
(iii) WBC Cells and WBC Casts
Acute interstitial nephritis
Acute pyelonephritis
(iv) RTE cells, RTE cell casts, pigmented granular (“muddy brown”)
casts
Acute tubular necrosis
39. Urine chemistries is helpful
1) ATN = tubular necrosis; tubular function is
impaired, thus high urine Na
(Reabsorption of water and sodium impaired in tubulo-
interstitial disease and ATN)
2) Pre-renal = intact tubular function, thus urine Na is
low
(Reabsorption of water and sodium intact in pre-renal
failure).
40. Red Blood Cell Cast
Two examples of red
blood cell casts, typical
of glomerular
bleeding.
41. Red Blood Cells
Monomorphic
(nondysmorphic)RBC
suggest non-glomerular
source of bleeding – i.e.,
bleeding from the
calyces, pelvis, ureter(s),
bladder, prostate or
urethra.
Dysmorphic red blood
cells suggest glomerular
injury.
Dysmorphic
42. Prevention of ARF
Recognize patients at risk (postoperative
states, cardiac surgery, septic shock)
Prevent progression from prerenal to renal
Preserve renal perfusion
– isovolemia, cardiac output, normal blood pressure
Avoid nephrotoxins (aminoglycosides,
NSAIDS, amphotericin)
43. Treatment of ARF
Based on type/etiology of AKI (acute kidney injury) i.e.,
pre-renal, post-renal, or intrinsic renal initially
– Pre-renal – volume, improve renal perfusion
– Post-renal – relieve obstruction
– Intrinsic – glomerular, tubular, interstitial, vascular
Depends on type
Follow clinically; attention to volume status, avoid
additional insults; treat complications of ARF
44. GENERAL PROTOCOL FOR
MANAGEMENT
Treat the underlying disease
Strictly monitor intake and output (weight,
urine output, insensible losses, IVF)
Monitor serum electrolytes
Adjust medication dosages according to GFR
Avoid highly nephrotoxic drugs
Attempt to convert oliguric to non-oliguric renal
failure (furosemide x 3)
45. Fluid therapy
If patient is fluid overloaded
• fluid restriction (insensible losses)
• attempt furosemide 1-2 mg/kg
• Renal replacement therapy
If patient is dehydrated:
• restore intravascular volume first
• then treat as euvolemic (below)
If patient is euvolemic:
• restrict to insensible losses (30-35 ml/100kcal/24 hours) +
other losses (urine, chest tubes, etc)
46. Sodium
most patients have dilutional hyponatremia
which should be treated with fluid restriction
severe hyponatremia (Na< 125 mEq/L) or
hypernatremia (Na> 150 mEq/L): dialysis or
hemofiltration
47. Potassium
Oliguric renal failure is often complicated by hyperkalemia,
increasing the risk in cardiac arrhythmias
Treatment of hyperkalemia:
– sodium bicarbonate (1-2 mEq/kg)
– insulin + hypertonic dextrose: 1 unit of insulin/4 g glucose
– sodium polystyrene (Kayexalate): 1 gm/kg . Can be repeated
qh.
(Hypernatremia and hypertension are potential
complications)
– dialysis
48. Nutrition
Provide adequate caloric intake
• limit protein intake to control increases in BUN
• minimize potassium and phosphorus intake
“Foods and fluid containing potassium or phosphorous (banana,
coffee) are restricted.”
• limit fluid intake
If adequate caloric intake can not be
achieved due to fluid limitations, some form
of dialysis should be considered
50. Hyperkalemia
A plasma K+
concentration > 6 mmol/l.
Must be treated immediately, to prevent the
development of life-threatening cardiac arrhythmias.
Never occurs in the absence of renal excretory
problem
Pseudohyperkalemia
– Leukocytosis
– Thrombocytosis
– Prolonged Application of Tourniquet
51. Hyperkalemia
Significance of urine output
Role of increased catabolism or tissue
breakdown
Factors affecting shift of Potassium out of cells
Etiololgy of the renal failure
52. Treatment of Hyperkalemia
Urgency
Role of the EKG in making the decision
Clinical setting in which it occurs
– Acute renal failure
– Chronic renal failure
53.
54. Table 5-3. Treatment of hyperkalemia
Medication Mechanism of action Dosage Peak effect
Calcium Antagonism of 10-30 ml of 10% solution IV -5 min
gluconate membrane over 2 min
Insulin and Increased K+
entry Insulin, 10 U IV bolus 30-60 min
Glucose into the cells followed by 0.5 mU/kg of
body weight per minute in
50 ml of 20% glucose
Sodium Increased K+
entry 44-50 mEq IV over 5 min; 30-60 min
bicarbonate into the cells can be repeated within 30
min
Albuterol Increased K+
entry
into the cells 20 mg in the nebulized form 30-60 min
Kayexalate Removal of the 20 g of resin with 100 ml of 2-4 hr
excess K+
20% sorbitol; can be
repeated every 4-6 hr
Hemodialysis Removal of the Dialysis bath K+
concentration 30-60 min
excess K+
variable
55. Indications for Dialysis
A – acidosis
E – electrolyte disturb., usually hyperkalemia
I – intoxications (lithium, ethylene glycol, etc)
O – overload (volume overload)
U – uremia (symptoms, signs)
56. COMPLICATIONS
ARF can affect the entire body
Infection
Hyperkalaemia, Hyperphosphataemia,
hyponatraemia
water overload
Pericarditis
Pulmonary oedema.
Reduced level of consciousness.
Immune deficiency.
57. ARF -- Summary
Dx AKI by falling GFR [rising BUN and
creatinine]
Classify into pre-renal, renal, or postrenal by
history, PE, BUN:creat ratio, urine analysis
Sometimes also need urine chemistries [urine
Na, FxExNa and/or FxExurea] to distinguish
pre-renal from ATN.
58. ARF – Summary (cont…)
Sometimes need renal ultrasound to verify
obstruction [post-renal ARF]
Rarely need other studies, esp to dx type of
intrinsic ARF [e.g., kidney biopsy: GN vs
interstitial nephritis vs ATN].
59. ARF – Summary (cont…)
Distinguishing the types of intrinsic ARF
usually depends on history, PE, urine analysis
– Vascular – large or small vessels
– Tubular = ATN
– Interstitial = AIN
– Glomerular = acute GN