2. Top Cancer Research Papers
Table of Contents
1. 3D Tumor Imaging 1-2
2. Angiogenesis 2-3
3. Bladder Cancer 3
4. Breast Cancer 3
5. Contrast Imaging 3-4
6. Gallbladder Cancer 4
7. Hepatic Cancer 4
8. Lymphoma 4-5
9. Melanoma 5
10. Ovarian Cancer 5
11. Pancreatic Cancer 5
12. Power Doppler 5-6
13. Prostate Cancer 6
14. Squamous Cell Carcinoma 6
15. Subcutaneous Lung Cancer 7
16. Thyroid Cancer 7
17. Vascularity 7
3. Bibliography – Cancer Research
3D Tumor Imaging
• Molecular imaging of therapeutic response to epidermal growth factor receptor blockade in
colorectal cancer.
Manning HC, Merchant NB, Foutch AC, Virostko JM, Wyatt SK, Shah C, et al.
Clin Cancer Res 2008 Nov 15;14(22):7413-22.
• Volumetric high-frequency Doppler ultrasound enables the assessment of early
antiangiogenic therapy effects on tumor xenografts in nude mice.
Jugold M, Palmowski M, Huppert J, Woenne EC, Mueller MM, Semmler W, et al.
Eur Radiol 2008 Apr;18(4):753-8.
• Targeting Notch signaling in autoimmune and lymphoproliferative disease.
Teachey DT, Seif AE, Brown VI, Bruno M, Bunte RM, Chang YJ, et al.
Blood 2008 Jan 15;111(2):705-14.
• Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating
endothelial cells: the role of oxidative stress.
Dong LF, Swettenham E, Eliasson J, Wang XF, Gold M, Medunic Y, et al.
Cancer Res 2007 Dec 15;67(24):11906-13.
• Ovarian volume measurements in mice with high-resolution ultrasonography.
Lyshchik A, Hobbs SB, Fleischer AC, Khabele D, Son DS, Gore JC, et al.
J Ultrasound Med 2007 Oct;26(10):1419-25.
• A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2
expression.
Wang XF, Birringer M, Dong LF, Veprek P, Low P, Swettenham E, et al.
Cancer Res 2007 Apr 1;67(7):3337-44.
• Functional neoangiogenesis imaging of genetically engineered mouse prostate cancer
using three-dimensional power Doppler ultrasound.
Xuan JW, Bygrave M, Jiang H, Valiyeva F, Dunmore-Buyze J, Holdsworth DW, et al.
Cancer Res 2007 Mar 15;67(6):2830-9.
• Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors.
Shaked Y, Ciarrocchi A, Franco M, Lee CR, Man S, Cheung AM, et al.
Science 2006 Sep 22;313(5794):1785-7.
• Rapamycin improves lymphoproliferative disease in murine autoimmune
lymphoproliferative syndrome (ALPS).
Teachey DT, Obzut DA, Axsom K, Choi JK, Goldsmith KC, Hall J, et al.
Blood 2006 Sep 15;108(6):1965-71.
• Volume measurement variability in three-dimensional high-frequency ultrasound images of
murine liver metastases.
Wirtzfeld LA, Graham KC, Groom AC, Macdonald IC, Chambers AF, Fenster A, et al.
Phys Med Biol 2006 May 21;51(10):2367-81.
1
4. Bibliography – Cancer Research
• Nanosecond pulsed electric fields cause melanomas to self-destruct.
Nuccitelli R, Pliquett U, Chen X, Ford W, James Swanson R, Beebe SJ, et al.
Biochem Biophys Res Commun 2006 May 5;343(2):351-60.
• Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term
and long-term impairment of vascular function and increase in tumor hypoxia.
Franco M, Man S, Chen L, Emmenegger U, Shaked Y, Cheung AM, et al.
Cancer Res 2006 Apr 1;66(7):3639-48.
• Establishment of a serum tumor marker for preclinical trials of mouse prostate cancer
models.
Huizen IV, Wu G, Moussa M, Chin JL, Fenster A, Lacefield JC, et al.
Clin Cancer Res 2005 Nov 1;11(21):7911-9.
• The use of three-dimensional ultrasound micro-imaging to monitor prostate tumor
development in a transgenic prostate cancer mouse model.
Wu G, Wang L, Yu L, Wang H, Xuan JW.
Tohoku J Exp Med 2005 Nov;207(3):181-9.
• Three-dimensional high-frequency ultrasound imaging for longitudinal evaluation of liver
metastases in preclinical models.
Graham KC, Wirtzfeld LA, MacKenzie LT, Postenka CO, Groom AC, MacDonald IC, et al.
Cancer Res 2005 Jun 15;65(12):5231-7.
Angiogenesis
• Anti-alphav integrin monoclonal antibody intetumumab enhances the efficacy of radiation
therapy and reduces metastasis of human cancer xenografts in nude rats.
Ning S, Tian J, Marshall DJ, Knox SJ.
Cancer Res. 2010 Oct 1;70(19):7591-9.
• Antiangiogenic cancer therapy: monitoring with molecular US and a clinically translatable
contrast agent (BR55).
Pysz MA, Foygel K, Rosenberg J, Gambhir SS, Schneider M, Willmann JK.
Radiology. 2010 Aug;256(2):519-27.
• Targeted contrast-enhanced ultrasound imaging of tumor angiogenesis with contrast
microbubbles conjugated to integrin-binding knottin peptides.
Willmann JK, Kimura RH, Deshpande N, Lutz AM, Cochran JR, Gambhir SS.
J Nucl Med. 2010 Mar;51(3):433-40
• Correlation between 2- and 3-dimensional assessment of tumor volume and vascular
density by ultrasonography in a transgenic mouse model of mammary carcinoma.
Zhao L, Zhan Y, Rutkowski JL, Feuerstein GZ, Wang X.
J Ultrasound Med. 2010 Apr;29(4):587-95.
• Vessel fractions in tumor xenografts depicted by flow- or contrast-sensitive three-
dimensional high-frequency Doppler ultrasound respond differently to antiangiogenic
treatment.
Palmowski M, Huppert J, Hauff P, Reinhardt M, Schreiner K, Socher MA, et al.
Cancer Res 2008 Sep 1;68(17):7042-9.
2
5. Bibliography – Cancer Research
• Volumetric high-frequency Doppler ultrasound enables the assessment of early
antiangiogenic therapy effects on tumor xenografts in nude mice.
Jugold M, Palmowski M, Huppert J, Woenne EC, Mueller MM, Semmler W, et al.
Eur Radiol 2008 Apr;18(4):753-8.
• US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial
growth factor receptor type 2 in mice.
Willmann JK, Paulmurugan R, Chen K, Gheysens O, Rodriguez-Porcel M, Lutz AM, et al.
Radiology 2008 Feb;246(2):508-18.
• Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating
endothelial cells: the role of oxidative stress.
Dong LF, Swettenham E, Eliasson J, Wang XF, Gold M, Medunic Y, et al.
Cancer Res 2007 Dec 15;67(24):11906-13.
• Molecular imaging of vascular endothelial growth factor receptor 2 expression using
targeted contrast-enhanced high-frequency ultrasonography.
Lyshchik A, Fleischer AC, Huamani J, Hallahan DE, Brissova M, Gore JC.
J Ultrasound Med 2007 Nov;26(11):1575-86.
• Detecting vascular changes in tumour xenografts using micro-ultrasound and micro-ct
following treatment with VEGFR-2 blocking antibodies.
Cheung AM, Brown AS, Cucevic V, Roy M, Needles A, Yang V, et al.
Ultrasound Med Biol 2007 Aug;33(8):1259-68.
• Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term
and long-term impairment of vascular function and increase in tumor hypoxia.
Franco M, Man S, Chen L, Emmenegger U, Shaked Y, Cheung AM, et al.
Cancer Res 2006 Apr 1;66(7):3639-48.
Bladder Cancer
• Oncolytic viral therapy by bladder instillation using an E1A, E1B double-restricted
adenovirus in an orthotopic bladder cancer model.
Wang H, Satoh M, Abe H, Sunamura M, Moriya T, Ishidoya S, et al.
Urology 2006 Sep;68(3):674-81.
Breast Cancer
• A method for assessing the microvasculature in a murine tumor model using contrast-
enhanced ultrasonography.
Loveless ME, Li X, Huamani J, Lyshchik A, Dawant B, Hallahan D, et al.
J Ultrasound Med 2008 Dec;27(12):1699-709.
• Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating
endothelial cells: the role of oxidative stress.
Dong LF, Swettenham E, Eliasson J, Wang XF, Gold M, Medunic Y, et al.
Cancer Res 2007 Dec 15;67(24):11906-13.
• A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2
expression.
3
6. Bibliography – Cancer Research
Wang XF, Birringer M, Dong LF, Veprek P, Low P, Swettenham E, et al.
Cancer Res 2007 Apr 1;67(7):3337-44.
• Molecular imaging of vascular endothelial growth factor receptor 2 expression using
targeted contrast-enhanced high-frequency ultrasonography.
Lyshchik A, Fleischer AC, Huamani J, Hallahan DE, Brissova M, Gore JC.
J Ultrasound Med 2007 Nov;26(11):1575-86.
• Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term
and long-term impairment of vascular function and increase in tumor hypoxia.
Franco M, Man S, Chen L, Emmenegger U, Shaked Y, Cheung AM, et al.
Cancer Res 2006 Apr 1;66(7):3639-48.
Colon Cancer
• Antiangiogenic cancer therapy: monitoring with molecular US and a clinically translatable
contrast agent (BR55).
Pysz MA, Foygel K, Rosenberg J, Gambhir SS, Schneider M, Willmann JK.
Radiology. 2010 Aug;256(2):519-27.
Contrast Imaging
• Correlation of quantified contrast-enhanced sonography with in vivo tumor response.
Hwang M, Hariri G, Lyshchik A, Hallahan DE, Fleischer AC.
J Ultrasound Med. 2010 Apr;29(4):597-607.
• Antiangiogenic cancer therapy: monitoring with molecular US and a clinically translatable
contrast agent (BR55).
Pysz MA, Foygel K, Rosenberg J, Gambhir SS, Schneider M, Willmann JK.
Radiology. 2010 Aug;256(2):519-27.
• IFN-beta restricts tumor growth and sensitizes alveolar rhabdomyosarcoma to ionizing
radiation.
Sims TL, McGee M, Williams RF, Myers AL, Tracey L, Hamner JB, et al.
Mol Cancer Ther 2010 Mar;9(3):761-71.
• Targeted contrast-enhanced ultrasound imaging of tumor angiogenesis with contrast
microbubbles conjugated to integrin-binding knottin peptides.
Willmann JK, Kimura RH, Deshpande N, Lutz AM, Cochran JR, Gambhir SS.
J Nucl Med. 2010 Mar;51(3):433-40.
• Correlation between 2- and 3-dimensional assessment of tumor volume and vascular
density by ultrasonography in a transgenic mouse model of mammary carcinoma.
Zhao L, Zhan Y, Rutkowski JL, Feuerstein GZ, Wang X.
J Ultrasound Med. 2010 Apr;29(4):587-95.
• A method for assessing the microvasculature in a murine tumor model using contrast-
enhanced ultrasonography.
Loveless ME, Li X, Huamani J, Lyshchik A, Dawant B, Hallahan D, et al.
J Ultrasound Med 2008 Dec;27(12):1699-709.
4
7. Bibliography – Cancer Research
• Molecular imaging of vascular endothelial growth factor receptor 2 expression using
targeted contrast-enhanced high-frequency ultrasonography.
Lyshchik A, Fleischer AC, Huamani J, Hallahan DE, Brissova M, Gore JC.
J Ultrasound Med 2007 Nov;26(11):1575-86.
• Detecting vascular changes in tumour xenografts using micro-ultrasound and micro-ct
following treatment with VEGFR-2 blocking antibodies.
Cheung AM, Brown AS, Cucevic V, Roy M, Needles A, Yang V, et al.
Ultrasound Med Biol 2007 Aug;33(8):1259-68.
Gallbladder Tumor
• Therapeutic effect of CS-706, a specific cyclooxygenase-2 inhibitor, on gallbladder
carcinoma in BK5.ErbB-2 mice.
Kiguchi K, Ruffino L, Kawamoto T, Franco E, Kurakata S, Fujiwara K, et al.
Mol Cancer Ther 2007 Jun;6(6):1709-17.
• Chemopreventive and therapeutic efficacy of orally active tyrosine kinase inhibitors in a
transgenic mouse model of gallbladder carcinoma.
Kiguchi K, Ruffino L, Kawamoto T, Ajiki T, Digiovanni J.
Clin Cancer Res 2005 Aug 1;11(15):5572-80.
Hepatic Cancer
• Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of
human hepatocellular carcinoma in a rat xenograft model.
Bagi CM, Christensen J, Cohen DP, Roberts WG, Wilkie D, Swanson T, et al.
Cancer Biol Ther 2009 May;8(9):856-65.
• Volume measurement variability in three-dimensional high-frequency ultrasound images of
murine liver metastases.
Wirtzfeld LA, Graham KC, Groom AC, Macdonald IC, Chambers AF, Fenster A, et al.
Phys Med Biol 2006 May 21;51(10):2367-81.
• Transgenic expression of Angiopoietin 1 in the liver leads to changes in lymphatic and
blood vessel architecture.
Haninec AL, Voskas D, Needles A, Brown AS, Foster FS, Dumont DJ.
Biochem Biophys Res Commun 2006 Jul 14;345(4):1299-307.
• Three-dimensional high-frequency ultrasound imaging for longitudinal evaluation of liver
metastases in preclinical models.
Graham KC, Wirtzfeld LA, MacKenzie LT, Postenka CO, Groom AC, MacDonald IC, et al.
Cancer Res 2005 Jun 15;65(12):5231-7.
Lymphoma
• Targeting Notch signaling in autoimmune and lymphoproliferative disease.
Teachey DT, Seif AE, Brown VI, Bruno M, Bunte RM, Chang YJ, et al.
Blood 2008 Jan 15;111(2):705-14.
5
8. Bibliography – Cancer Research
• Rapamycin improves lymphoproliferative disease in murine autoimmune
lymphoproliferative syndrome (ALPS).
Teachey DT, Obzut DA, Axsom K, Choi JK, Goldsmith KC, Hall J, et al.
Blood 2006 Sep 15;108(6):1965-71.
Mammary Tumors
• Correlation between 2- and 3-dimensional assessment of tumor volume and vascular
density by ultrasonography in a transgenic mouse model of mammary carcinoma.
Zhao L, Zhan Y, Rutkowski JL, Feuerstein GZ, Wang X.
J Ultrasound Med. 2010 Apr;29(4):587-95.
• A method for assessing the microvasculature in a murine tumor model using contrast-
enhanced ultrasonography.
Loveless ME, Li X, Huamani J, Lyshchik A, Dawant B, Hallahan D, et al.
J Ultrasound Med 2008 Dec;27(12):1699-709.
• Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating
endothelial cells: the role of oxidative stress.
Dong LF, Swettenham E, Eliasson J, Wang XF, Gold M, Medunic Y, et al.
Cancer Res 2007 Dec 15;67(24):11906-13.
• Molecular imaging of vascular endothelial growth factor receptor 2 expression using
targeted contrast-enhanced high-frequency ultrasonography.
Lyshchik A, Fleischer AC, Huamani J, Hallahan DE, Brissova M, Gore JC.
J Ultrasound Med 2007 Nov;26(11):1575-86.
• Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term
and long-term impairment of vascular function and increase in tumor hypoxia.
Franco M, Man S, Chen L, Emmenegger U, Shaked Y, Cheung AM, et al.
Cancer Res 2006 Apr 1;66(7):3639-48.
Melanoma
• Nanosecond pulsed electric fields cause melanomas to self-destruct.
Nuccitelli R, Pliquett U, Chen X, Ford W, James Swanson R, Beebe SJ, et al.
Biochem Biophys Res Commun 2006 May 5;343(2):351-60.
Ovarian Cancer
• Targeted contrast-enhanced ultrasound imaging of tumor angiogenesis with contrast
microbubbles conjugated to integrin-binding knottin peptides.
Willmann JK, Kimura RH, Deshpande N, Lutz AM, Cochran JR, Gambhir SS.
J Nucl Med. 2010 Mar;51(3):433-40
• Ovarian volume measurements in mice with high-resolution ultrasonography.
Lyshchik A, Hobbs SB, Fleischer AC, Khabele D, Son DS, Gore JC, et al.
J Ultrasound Med 2007 Oct;26(10):1419-25.
6
9. Bibliography – Cancer Research
Pancreatic Cancer
• Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of
pancreatic cancer.
Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, et al.
Science 2009 Jun 12;324(5933):1457-61.
• Complementarity of ultrasound and fluorescence imaging in an orthotopic mouse model of
pancreatic cancer.
Snyder CS, Kaushal S, Kono Y, Tran Cao HS, Hoffman RM, Bouvet M.
BMC Cancer 2009 Apr 8;9:106.
• An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor
initiation and metastasis in pancreatic cancer.
Feldmann G, Fendrich V, McGovern K, Bedja D, Bisht S, Alvarez H, et al.
Mol Cancer Ther 2008 Sep;7(9):2725-35.
• TRA-8 anti-DR5 monoclonal antibody and gemcitabine induce apoptosis and inhibit
radiologically validated orthotopic pancreatic tumor growth.
Derosier LC, Vickers SM, Zinn KR, Huang Z, Wang W, Grizzle WE, et al.
Mol Cancer Ther 2007 Dec;6(12 Pt 1):3198-207.
• Combination treatment with TRA-8 anti death receptor 5 antibody and CPT-11 induces
tumor regression in an orthotopic model of pancreatic cancer.
DeRosier LC, Buchsbaum DJ, Oliver PG, Huang ZQ, Sellers JC, Grizzle WE, et al.
Clin Cancer Res 2007 Sep 15;13(18 Pt 2):5535s-5543s.
Power Doppler
• Correlation of quantified contrast-enhanced sonography with in vivo tumor response.
Hwang M, Hariri G, Lyshchik A, Hallahan DE, Fleischer AC.
J Ultrasound Med. 2010 Apr;29(4):597-607.
• Vessel fractions in tumor xenografts depicted by flow- or contrast-sensitive three-
dimensional high-frequency Doppler ultrasound respond differently to antiangiogenic
treatment.
Palmowski M, Huppert J, Hauff P, Reinhardt M, Schreiner K, Socher MA, et al.
Cancer Res 2008 Sep 1;68(17):7042-9.
• Volumetric high-frequency Doppler ultrasound enables the assessment of early
antiangiogenic therapy effects on tumor xenografts in nude mice.
Jugold M, Palmowski M, Huppert J, Woenne EC, Mueller MM, Semmler W, et al.
Eur Radiol 2008 Apr;18(4):753-8.
• Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating
endothelial cells: the role of oxidative stress.
Dong LF, Swettenham E, Eliasson J, Wang XF, Gold M, Medunic Y, et al.
Cancer Res 2007 Dec 15;67(24):11906-13.
• Functional neoangiogenesis imaging of genetically engineered mouse prostate cancer
using three-dimensional power Doppler ultrasound.
7
10. Bibliography – Cancer Research
Xuan JW, Bygrave M, Jiang H, Valiyeva F, Dunmore-Buyze J, Holdsworth DW, et al.
Cancer Res 2007 Mar 15;67(6):2830-9.
• Nanosecond pulsed electric fields cause melanomas to self-destruct.
Nuccitelli R, Pliquett U, Chen X, Ford W, James Swanson R, Beebe SJ, et al.
Biochem Biophys Res Commun 2006 May 5;343(2):351-60.
Prostate Cancer
• Inhibition of tumor growth progression by antiandrogens and mTOR inhibitor in a Pten-
deficient mouse model of prostate cancer.
Zhang W, Zhu J, Efferson CL, Ware C, Tammam J, Angagaw M, et al.
Cancer Res 2009 Sep 15;69(18):7466-72.
• Functional neoangiogenesis imaging of genetically engineered mouse prostate cancer
using three-dimensional power Doppler ultrasound.
Xuan JW, Bygrave M, Jiang H, Valiyeva F, Dunmore-Buyze J, Holdsworth DW, et al.
Cancer Res 2007 Mar 15;67(6):2830-9.
• Establishment of a serum tumor marker for preclinical trials of mouse prostate cancer
models.
Huizen IV, Wu G, Moussa M, Chin JL, Fenster A, Lacefield JC, et al.
Clin Cancer Res 2005 Nov 1;11(21):7911-9.
• The use of three-dimensional ultrasound micro-imaging to monitor prostate tumor
development in a transgenic prostate cancer mouse model.
Wu G, Wang L, Yu L, Wang H, Xuan JW.
Tohoku J Exp Med 2005 Nov;207(3):181-9.
Squamous Cell Carcinoma
• Volumetric high-frequency Doppler ultrasound enables the assessment of early
antiangiogenic therapy effects on tumor xenografts in nude mice.
Jugold M, Palmowski M, Huppert J, Woenne EC, Mueller MM, Semmler W, et al.
Eur Radiol 2008 Apr;18(4):753-8.
Subcutaneous Lung Cancer
• Correlation of quantified contrast-enhanced sonography with in vivo tumor response.
Hwang M, Hariri G, Lyshchik A, Hallahan DE, Fleischer AC.
J Ultrasound Med. 2010 Apr;29(4):597-607.
• Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors.
Shaked Y, Ciarrocchi A, Franco M, Lee CR, Man S, Cheung AM, et al.
Science 2006 Sep 22;313(5794):1785-7.
Thyroid Cancer
• Morphological ultrasound microimaging of thyroid in living mice.
Mancini M, Vergara E, Salvatore G, Greco A, Troncone G, Affuso A, et al.
Endocrinology 2009 Oct;150(10):4810-5.
8
11. Bibliography – Cancer Research
Vascularity
• Correlation of quantified contrast-enhanced sonography with in vivo tumor response.
Hwang M, Hariri G, Lyshchik A, Hallahan DE, Fleischer AC.
J Ultrasound Med. 2010 Apr;29(4):597-607.
• Correlation between 2- and 3-dimensional assessment of tumor volume and vascular
density by ultrasonography in a transgenic mouse model of mammary carcinoma.
Zhao L, Zhan Y, Rutkowski JL, Feuerstein GZ, Wang X.
J Ultrasound Med. 2010 Apr;29(4):587-95.
• A method for assessing the microvasculature in a murine tumor model using contrast-
enhanced ultrasonography.
Loveless ME, Li X, Huamani J, Lyshchik A, Dawant B, Hallahan D, et al.
J Ultrasound Med 2008 Dec;27(12):1699-709.
• Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating
endothelial cells: the role of oxidative stress.
Dong LF, Swettenham E, Eliasson J, Wang XF, Gold M, Medunic Y, et al.
Cancer Res 2007 Dec 15;67(24):11906-13.
9
