EMC講演プレゼン構成案(2)

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Tsuyoshi Horigome

EMC講演プレゼン構成案(2)

Education

EMC
LTspice
(1)
FCC
FPGA
PFC MOSFET
(2)D
(3) DC
EMC .mmap - 2013/05/11 -

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Slides from a talk given at SfN 2016. The task of dividing the human brain into regions has been captivating scientists for many years. In the following work we revisit this challenge and introduce a new evaluation technique that works for both cortical and subcortical parcellations. Our approach is based on data from a diverse set of cognitive experiments that employs nonparametric methods to account for smoothness and parcel size biases. As reported before parcel variance was a function of parcel size in that smaller parcels were more likely to be homogenous (even in random data). However, when we used map-specific null distributions to account for both smoothness of statistical maps as well as number of parcels in atlases, unbiased estimates become apparent. Both Yeo et al. and Collins et al. parcellations produce scores for random data similar to those derived from real data. In contrast, Shen et al., AAL, and Gordon et al. show lower within parcel variance when applied to real data than when applied to random data (but no distinction can be made between them). In addition to looking at within parcel variance we also applied a novel metric based on the intuition that different parts of the brain should not only be homogenous, but also different from each other. To quantify this we calculated a ratio of between and within parcel variances (standardized using individual null models). This approach indirectly penalizes parcellations with too many unnecessary parcels. Using this measure we show that Yeo et al. parcellation fits data better (Figure 1) than Collins et al. atlas despite having fewer parcels (7 vs 10). We present a novel approach to evaluating atlases and parcellations of the human brain that captures diverse patterns observed across many cognitive studies. Our testing methodology overcomes biases introduced by the size of the parcels and smoothness of input data, but also, in contrast to previous methods, can be applied to whole brain volumetric data. We have found that in contrast to previous reports based on resting state cortico cortical connectivity Shen et al. and AAL atlases can delineate brain regions with above average accuracy.

Evaluation of full brain parcellation schemes using the NeuroVault database o...

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