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Pandemic Tech: How Emerging Technologies Can Mitigate the Impact of Covid-19 and Future Pandemics
1. Pandemic Tech: How emerging technologies
can mitigate the impact of Covid19 and
future pandemics
Sean T Manion PhD
Chief Scientific Officer @ ConsenSys Health
BHTY-DMV Chapter Virtual Meeting
24 April 2020
Sean T Manion, PhD - sean.manion@consensyshealth.com - April 2020
2. Old problems – New solutions
Major Issues and Challenges of Influenza
Pandemic Preparedness in Developing
Countries
Hitoshi Oshitani, Taro Kamigaki, and Akira Suzuki
• Availability of Vaccines and Antiviral Agents
• Limitations of Pharmaceutical Interventions
• Lack of Medical and Public Health
Infrastructure to Cope with a Pandemic
Emerg Infect Dis. 2008 Jun; 14(6): 875–880. doi:
10.3201/eid1406.070839
5 ways that blockchain tech can help us during
this pandemic
Don Tapscott and Alex Tapscott
• Self-sovereign identity, health records and
shared data
• Just-in-time supply chain solutions
• Sustaining the economy
• A rapid response registry for medical
professionals
• Incentive models to reward responsible
behavior
https://www.coindesk.com/five-ways-blockchain-tech-can-
help-us-during-this-pandemic
Sean T Manion, PhD - sean.manion@consensyshealth.com - April 2020
5. Judges
Dr. Jonathan Holt, DO, MS, FACMG
Chief Medical Informatics Officer for ConsenSys
Health
Joe Lubin
Founder of ConsenSys
Co-Founder of Ethereum
Dr. Alex Cahana, MD
Chief Medical Officer for
ConsenSys Health
Dr. Sean Manion, PhD
Chief Scientific Officer for
ConsenSys Health
Debbie Bucci
Director, Patient-Mediated & Institutional
Data Exchange for ConsenSys Health
Brian Behlendorf
Executive Director of
Hyperledger
Vitalik Buterin
Co-Founder of Ethereum
Heather Flannery
Founder and CEO for
ConsenSys Health
6. Defines Learning objectives
based on research or business
goals
Monitor performance
Analyze results and verifies that
objectives have been realized
Orchestrator smart contract
maintains registry for data &
compute discovery
Smart contract stores and
serves programs & parameters.
Auditor smart contract tracks
experiments, records data
access and model performance
Register their data and compute
resources, permissions and
privacy policies with the
Orchestrator smart contract.
Execute a multi-stakeholder
Intellectual property licensing
agreement (Licensing Smart
Contract)
Machine Learning
Analyst
Blockchain
Network
Data owners
Federated Healthcare Learning Platform
Accelerating discoveries with secure and collaborative analytics
Guarantees of Integrity
Tamper proof, with a unified audit trail and
oversight of data use
Collaborative Mechanisms
Drive Participation and Usage
● Collaboratively surface insights without
sacrificing data privacy
● Collective ownership and licensing of
intellectual property
● Decentralized governance and shared
decision-making
● Ability to use tokenization for incentivized
collaboration
Web3 Infrastructure for Enhanced Data Integrity, Privacy Preservation, and Increased Trust across Distributed Networks
Identity & Access Management
Discovery of workers, client-specific encryption
and decryption of content
Traceability
Verifiable model performance, experiment
tracking for reproducibility, verifiable compliance
7. Blockchain Healthcare Ecosystem
Key Use Cases Areas (Examples):
• Admin, financial (US Health & Human Services –
Accelerate Program)
• Provider identity/credentialing (Professional
Credential Exchange; Synaptic Health Alliance)
• Medical device tracking (Edinburgh Napier University,
NHS National Services Scotland, Spiritus Partners)
• Pharma supply chain (FDA: Good Shepherd
Pharmacy/Remedichain+; MediLedger/Walmart)
• Clinical trials (Boehringer Ingelheim/IBM; UCSF*)
• *Prototype of running clinical trials in an untrustworthy
environment using blockchain. Wong et al. Nature
Communications volume 10, Article: 917 (2019)
• Publishing (Ledger, ARTiFACTS, Journal of the British
Blockchain Association, Blockchain in Healthcare
Today, Springer Nature)
• Electronic health record (Amsys; Rymedi)
Sean T Manion, PhD - sean.manion@consensyshealth.com - April 2020
8. Blockchain for Medical Research:
Accelerating Trust in Healthcare
Sean Manion PhD &
Yaël Bizouati-Kennedy
(CRC Press, HIMSS Series)
31 March 2020
https://www.crcpress.com/Blockchain-for-Medical-Research-
Accelerating-Trust-in-Healthcare/Manion-Bizouati-
Kennedy/p/book/9780367347468
Sean T Manion, PhD - sean.manion@consensyshealth.com - April 2020
9. Farm to Table, Bench to Bedside: Health Research as Data Supply Chain
from “Advancing Health Research with Blockchain” (Manion) in HIMSS textbook
Blockchain in Healthcare: Innovations that Empower Patients, Connect Professionals and Improve Care
Sean T Manion, PhD - sean.manion@consensyshealth.com - April 2020
Seed
•Crop
•Strain
•Soil
Farm
•Plant
•Grow
•Harvest
Processing
•Cleaning
•Preparation
•Packaging
Distribution
•To consumer or
retail
•Next stage
processing
Table
•Restaurant
•Retail/Home
cooking
Idea
•Hypothesis
•Design
•Funding
Bench
•Research
execution
•Data Collection
•Basic to Clinical
Analysis
•Hypothesis
testing
•Statistics
•Interpretation
Dissemination
•Conference
presentation
•Peer-review
publication
Bedside
•Knowledge
translation
•Clinical practice
guidelines
Repeats several times
Food Supply Chain
• Linear progression
• Timeline: < 30 days*
• Key variables: type,
quantity, quality,
variables (e.g. temp)
Health Research Data
Supply Chain
• Parallel progression
• Timeline: 2-5yrs (x
multiple repeats)
• Key Variables: design,
methodology, patient
demographics research
contribution, statistical
approach, outcomes
10. Blockchain for Clinical Trial Administrationfrom Blockchain for Medical Research: Accelerating Trust in Healthcare Manion & Bizouati-Kennedy (April 2020, CRC Press)
Sean T Manion, PhD - sean.manion@consensyshealth.com - April 2020
11. The Way Forward
from Blockchain for Medical Research: Accelerating Trust in Healthcare Manion & Bizouati-Kennedy (April 2020, CRC Press)
Sean T Manion, PhD - sean.manion@consensyshealth.com - April 2020
Key Areas of Impact Recommendations
Sharing ideas/hypotheses Cross-agency, public-private, subject matter
working groups
Accelerated proposal review University and research group engagement
Funding innovations IEEE/NIST/ISO standards
Protocol development Strategic Planning
Enhanced data sharing Administrative pilots
Methods and analyses tracking Regulatory engagement
Pre-review of interpretations Network research pilots
Crowdsourced peer-review Enterprise deployment
Fractionalized publishing Distributed Autonomous Organization
12. Blockchain for Medical Research: Accelerating Trust
in Healthcare
Sean Manion PhD &
Yaël Bizouati-Kennedy
(CRC Press, HIMSS Series)
https://www.crcpress.com/Blockchain-for-Medical-Research-
Accelerating-Trust-in-Healthcare/Manion-Bizouati-
Kennedy/p/book/9780367347468
Read Chapter 15 – “The Roadmap” for FREE
https://sciencedistributed.com/talk/f/the-roadmap-excerpts-from-ch-
15-of-blockchain-for-med-research
(Go to Science Distributed .com, check out Blog/Talk)
OR find it in my articles on LinkedIn
Sean T Manion, PhD - sean.manion@consensyshealth.com - April 2020