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JDRF Type One Nation Summit
Howard Look
Founder and CEO
Palo Alto
September 18, 2016
My Motivation
Katie Look
First Day of 6th Grade, 2011
0
50
100
150
200
250
300
350
400
450
500
Noon 1pm 2pm 3pm 4pm
Blood Glucose (mg/dL)
Long term complications:
nerve damage, kidney failure,
blindness, amputation
Acute, short term dangers: 

cognitive impairment,
seizure, coma, death
Precise Insulin Dosing for T1D Depends On:
Current Blood Glucose
Insulin to Carbohydrate Ratio
Carbohydrates
Insulin on Board
Protein and Fat
Insulin Sensitivity Factor
Exercise
Menstrual Cycle
Stress
Illness
and much, much more…
c X
JPEG
View
A thought experiment: Digital Cameras
Access
Canon
Olympus
Kodak
A thought experiment: Digital Cameras
Access View?!
Canon
Olympus
Kodak
Canon
Olympus
Kodak
Your

choice
Your

choice
Access View
A thought experiment: Digital Cameras
How do you
access the data?
How do you
view the data?
What if your choice
isn’t right for me?
Your

choice
Your

choice
Access View
Proudly non-profit. Open source.
A platform for precision medicine.
Tidepool

Uploader
Nutshell
iLet Bionic Pancreas User Interface
Katie Look
mobile
Dad. I’m low.
I’m 52. And dropping.
I can’t find my juice boxes.
I don’t know where I am.
Closed Loop Telemetry Dashboard
Production
Environment
Amazon Web ServicesPublic Internet
Staging

Environment
Production
Environment
Staging

Environment
Development

Environment
MongoDB Master
MongoDB Slave
MongoDB Slave
S3 Backup MongoDB Master
Production DB Cluster
Staging/Dev DB
Secure, HIPAA-compliant
Software as a Service
JavaScript
Node.js
ReactJS
D3.js
Go
MongoDB
Tidepool Uploader
Data Authentication and
Validation
REST APIs
Visualization
Cloud

Data

APIs
Research
APIs
EHR APIs
Messaging

and

Notification APIs
APIs enabling an Ecosystem of Research and Therapy
Research App 1 Research App 2 Athlete App Pregnancy App
Blip Nutshell Sonar AP Remote Telemetry
A Vibrant Ecosystem Type 1 Diabetes Application
Bolus Calculators
Remote Monitoring
Apps for Teens
Clinical Decision
Support
T1D + Fitness Data
Research Apps
and Interfaces
Apps for Pregnant
Moms with T1D
Apps for Kids
Location-aware
Apps
Contextual Meal
Memory
Psycho-social
Research
Artificial PancreasApps for Elderly
Supply

Management
T1D Triathlete

Trainer
T1D

Telemedicine
California-based Collaboration
(in addition to 30+ other non-Californian clinics and research centers)
2013 2014
2015 2016
Founded
Seed

Funding
Platform
Uploader
Nutshell No Clinic Left Behind
Blip Pilot
at UCSF
Blip & Uploader

Released
Blip in Clinic
Goldsmith

Foundation
Founding Team Hired
Lean Launchpad
Dex G5
Apple Health
Nutshell

Beta
Diamond StudyReplaceBG Study
+ over 30 other
clinics
FDA Quality
System Published
Glycemia Study


Tidepool recognized as a

White House Champion of Change

for Precision Medicine

The Horace W. Goldsmith Foundation
Hundreds of Other Donors
Thank you!
tidepool.org
@Tidepool_org
howard@tidepool.org
@HowardLook

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2016-09-18 Tidepool at JDRF Type One Nation Summit, Palo Alto