SlideShare a Scribd company logo
1 of 16
BY
ASAWE TEJASWINI L
DEPARTMENT OF PHARMACOLOGY
ASSIASTANT PROFESSOR
SIDHHIS INSTITUTE OF PHARMACY
THANE
Drug Interaction
• A drug interaction has occurred when administration of
one drug alters the clinical effects of another .
• A drug interaction results when the effects of a drug are
altered in some way by the presence of another drug, by
food, or by environmental exposure.
• A drug–drug interaction increases with the number of
medications a patient is receiving can cause risk of
developing an adverse drug reaction (ADR).
Drug interaction
Drug – Drug Interaction
 A reaction between two or more drugs.
 This can involve prescription medications , over
the counter medicine (OTC) and herbs, vitamins ,
and supplements.
 Taking a drug while having certain medical
conditions can also cause a drug interaction.
 For example, taking a nasal decongestant if you
have high blood pressure may cause an
unwanted reaction.
 Warfarin ( prevent blood clots) with acetylsalicylic
acid (anti-inflammatory) may increase the risk of
bleeding.
 A drug-drug interaction (DDI) occurs
when the clinical effect of a given drug is
altered by the action of another drug.
 Importantly, drug interactions contribute
to the majority of adverse drug
reactions, and approximately 70% of
interactions are clinically relevant.
Drug Food Interaction
 When food or beverage intake alters a drugs
effect.
 If someone taking certain statins atorvastatin ,
rosuvastatin to lower cholesterol & drinks a lot of
grapefruit juice can cause too much of drug in
body.
 This may increase their risk for liver damage or
kidney failure.
 Ex. ANTIBIOTICS with milk products that complex
with some antibiotics and prevent their
absorption. reduced bioavailability
Drug – Alcohol Interaction
 Certain medication should not be taken with
alcohol.
 Combination of alcohol with drugs can cause
tiredness and delayed reactions, can also your risk
for negative side effects.
 Ex. drug interaction between warfarin and alcohol,
which could increase bleeding risk.
 medications can interact with alcohol, including
antibiotics, antidepressants, muscle relaxants,
anti-inflammatory agents and warfarin.
Drug - Disease Interaction
 The drugs that alters or worsen a condition or
disease.
 Ex. taking a nasal decongestant for cold can
increase blood pressure .
 This is potentially dangerous dangerous
interaction for people with high blood pressure
may cause an unwanted reaction.
Drug Laboratory Interaction
 Medication interferes with laboratory test.
 This can result in inaccurate test.
 For example, cephalosporin's may alter urine
glucose and ketone tests.
 Certain antidepressants have been shown to
interfere with skin prick test used to determine
allegy.
DRUG INTERACTION
PHARMACEUTICAL
(OUTSIDE THE BODY )
PHARMACOLOGICAL
(INSIDE THE BODY
PHYSICAL
CHEMICAL
PHARMACODYNA
MIC
PHARMACOKINE
TIC
ANTAGONIS
T
ADDITIVE
SYNERGIST
IC
ABSORPTIO
N
DISTRIBUTIO
N
METABOLIS
M
EXCRETION
Pharmaceutical Interaction
 Pharmaceutical interaction can be divided into
chemical and physical reaction.
 A chemical reaction is occurs due to the
incompatibility between two drugs administered at
the same time.
 Ex. phenytoin and lorazepam become ineffective
if mixed together in the same IV bag or syringe.
 Physical reaction occurs when physically altering
a drug formulation such as by crushing a
sustained release tablet , drug release more
quickly and in large amount.
Pharmacological Interaction
 Pharmacological Interaction most commonly occurring in
drug -drug interaction.
 Pharmacological interaction are classified as
pharmacodynamic & pharmacokinetic interaction .
 Pharmacokinetic interactions results from alteration in a
drugs absorption , distribution , metabolism and excretion
characteristics.
Pharmacodynamic interactions
 Pharmacodynamic interactions are those in which one drug influence
each others effect directly .
 Such interactions are of particular importance when chemotherapy
drugs that are nephrotoxic are combined.
 An additive Pharmacodynamic effect when two or more drugs with
similar Pharmacodynamic effect are given , the additive effect may
result in excessive response and toxicity .
 additive Pharmacodynamic effect When on the kidneys can lead to
mild-to-moderate renal failure.
 Antagonistic Pharmacodynamic effect may reduce response to one or
both drug .
 Ex when acetylsalicylic acid combined with ibuprofen it reduced the
drug effect .
Pharmacokinetic interaction
 pharmacokinetic interaction occurs when one medication alters
the absorption, distribution, metabolism, or excretion of another.
 The effect of other drugs or non medicinal products on the
amount of chemotherapeutic drug absorbed is especially
important in the case of orally administered drugs.
 Food intake may increase or decrease these drugs' absorption.
 For example, it is important that capecitabine be taken within 30
minutes after a meal.
 The safety of capecitabine taken on an empty stomach has not
been established.
 When pharmacists dispense prescriptions for these agents, it is
essential that they make patients aware of the effect or food or
drugs.
How can a person avoid drug
interactions?
 You can take the following steps to avoid drug
interactions:
 Tell your health care provider about all prescription and
nonprescription medicines you are taking or plan to
take.
 Also tell your health care provider about any vitamins,
nutritional supplements, and herbal products you take.
 Tell your health care provider about any other
conditions you may have, such as high blood pressure
or diabetes.
 Take medicines according to your health care provider's
instructions.
 Always read the information and directions that come
with a medicine.
Thank You

More Related Content

Similar to Drug interaction.pptx

Drug Interaction.pptx
Drug Interaction.pptxDrug Interaction.pptx
Drug Interaction.pptxBimal Magar
 
DRUG INTERACTIONS (MECHANISMS OF DRUG-DRUG INTERACTIONS)
DRUG INTERACTIONS (MECHANISMS OF DRUG-DRUG INTERACTIONS)DRUG INTERACTIONS (MECHANISMS OF DRUG-DRUG INTERACTIONS)
DRUG INTERACTIONS (MECHANISMS OF DRUG-DRUG INTERACTIONS)N Anusha
 
Drug interactions their types, examples and role
Drug interactions their types, examples and roleDrug interactions their types, examples and role
Drug interactions their types, examples and roleYousra Ashraf
 
Consequences of drug interactions a concised
Consequences of drug interactions a concisedConsequences of drug interactions a concised
Consequences of drug interactions a concisedvallampati prudhvi
 
Drug Interaction.pptx
Drug Interaction.pptxDrug Interaction.pptx
Drug Interaction.pptxnayanabaste
 
Drug interaction - Potential antimicrobial drug interaction in a hospital set...
Drug interaction - Potential antimicrobial drug interaction in a hospital set...Drug interaction - Potential antimicrobial drug interaction in a hospital set...
Drug interaction - Potential antimicrobial drug interaction in a hospital set...Dr. Jibin Mathew
 
Chapter 11 human variability
Chapter 11 human variabilityChapter 11 human variability
Chapter 11 human variabilityAnn Bentley
 
Drug Interaction - for Pg class.pptx
Drug Interaction - for  Pg class.pptxDrug Interaction - for  Pg class.pptx
Drug Interaction - for Pg class.pptxDRKSVINAYKUMAR
 
Ar medical conditions and dental care-dental toxicology
Ar medical conditions and dental care-dental toxicologyAr medical conditions and dental care-dental toxicology
Ar medical conditions and dental care-dental toxicologyIyad Abou Rabii
 
Adverse drug reaction- Drug Interaction .pptx
Adverse drug reaction- Drug Interaction .pptxAdverse drug reaction- Drug Interaction .pptx
Adverse drug reaction- Drug Interaction .pptxMangeshBansod2
 

Similar to Drug interaction.pptx (20)

Drug and food interaction
Drug and food interactionDrug and food interaction
Drug and food interaction
 
Drug Interaction.pptx
Drug Interaction.pptxDrug Interaction.pptx
Drug Interaction.pptx
 
DRUG INTERACTIONS (MECHANISMS OF DRUG-DRUG INTERACTIONS)
DRUG INTERACTIONS (MECHANISMS OF DRUG-DRUG INTERACTIONS)DRUG INTERACTIONS (MECHANISMS OF DRUG-DRUG INTERACTIONS)
DRUG INTERACTIONS (MECHANISMS OF DRUG-DRUG INTERACTIONS)
 
Drug distribution sjk
Drug distribution  sjkDrug distribution  sjk
Drug distribution sjk
 
Drug interactions their types, examples and role
Drug interactions their types, examples and roleDrug interactions their types, examples and role
Drug interactions their types, examples and role
 
Consequences of drug interactions a concised
Consequences of drug interactions a concisedConsequences of drug interactions a concised
Consequences of drug interactions a concised
 
Herbal drug interactions
Herbal drug interactionsHerbal drug interactions
Herbal drug interactions
 
Drug Interaction.pptx
Drug Interaction.pptxDrug Interaction.pptx
Drug Interaction.pptx
 
Drug interactions
Drug interactionsDrug interactions
Drug interactions
 
Drugs interactions in general practice
Drugs interactions in general practiceDrugs interactions in general practice
Drugs interactions in general practice
 
Drug drug inter-action of pulmonary concern
Drug drug inter-action of pulmonary concernDrug drug inter-action of pulmonary concern
Drug drug inter-action of pulmonary concern
 
Drug interactions
Drug interactionsDrug interactions
Drug interactions
 
Drug interaction - Potential antimicrobial drug interaction in a hospital set...
Drug interaction - Potential antimicrobial drug interaction in a hospital set...Drug interaction - Potential antimicrobial drug interaction in a hospital set...
Drug interaction - Potential antimicrobial drug interaction in a hospital set...
 
Chapter 11 human variability
Chapter 11 human variabilityChapter 11 human variability
Chapter 11 human variability
 
HERB-FOOD INTERACTIONS
HERB-FOOD INTERACTIONSHERB-FOOD INTERACTIONS
HERB-FOOD INTERACTIONS
 
Drug Interaction - for Pg class.pptx
Drug Interaction - for  Pg class.pptxDrug Interaction - for  Pg class.pptx
Drug Interaction - for Pg class.pptx
 
Drug interactions
Drug interactionsDrug interactions
Drug interactions
 
INteraksi Obat II.pdf
INteraksi Obat II.pdfINteraksi Obat II.pdf
INteraksi Obat II.pdf
 
Ar medical conditions and dental care-dental toxicology
Ar medical conditions and dental care-dental toxicologyAr medical conditions and dental care-dental toxicology
Ar medical conditions and dental care-dental toxicology
 
Adverse drug reaction- Drug Interaction .pptx
Adverse drug reaction- Drug Interaction .pptxAdverse drug reaction- Drug Interaction .pptx
Adverse drug reaction- Drug Interaction .pptx
 

More from TejaswiniAsawa

More from TejaswiniAsawa (16)

GA & Pre A.pptx
GA & Pre A.pptxGA & Pre A.pptx
GA & Pre A.pptx
 
ADR.pptx
ADR.pptxADR.pptx
ADR.pptx
 
CLINICAL TRIALS.pptx
CLINICAL TRIALS.pptxCLINICAL TRIALS.pptx
CLINICAL TRIALS.pptx
 
Pharmacodynamics.pptx
Pharmacodynamics.pptxPharmacodynamics.pptx
Pharmacodynamics.pptx
 
Production Of Pharamaceuticals (1).pptx
Production Of Pharamaceuticals (1).pptxProduction Of Pharamaceuticals (1).pptx
Production Of Pharamaceuticals (1).pptx
 
Microbial Biotransformation.pptx
Microbial Biotransformation.pptxMicrobial Biotransformation.pptx
Microbial Biotransformation.pptx
 
IMMUNOBLOTTING TECHNIQUE.pptx
IMMUNOBLOTTING TECHNIQUE.pptxIMMUNOBLOTTING TECHNIQUE.pptx
IMMUNOBLOTTING TECHNIQUE.pptx
 
FERMENTATION..pptx
FERMENTATION..pptxFERMENTATION..pptx
FERMENTATION..pptx
 
mutation.pptx
mutation.pptxmutation.pptx
mutation.pptx
 
immunoblotting techniques.pptx
immunoblotting techniques.pptximmunoblotting techniques.pptx
immunoblotting techniques.pptx
 
eukaryotics.pptx
eukaryotics.pptxeukaryotics.pptx
eukaryotics.pptx
 
IMMUNITY.pptx
IMMUNITY.pptxIMMUNITY.pptx
IMMUNITY.pptx
 
hybridoma technology.pptx
hybridoma technology.pptxhybridoma technology.pptx
hybridoma technology.pptx
 
Protein Engineering.pptx
Protein Engineering.pptxProtein Engineering.pptx
Protein Engineering.pptx
 
GENETIC ENGINEERING.pptx
GENETIC ENGINEERING.pptxGENETIC ENGINEERING.pptx
GENETIC ENGINEERING.pptx
 
BIOSENSOR.pptx
BIOSENSOR.pptxBIOSENSOR.pptx
BIOSENSOR.pptx
 

Recently uploaded

97111 47426 Call Girls In Delhi MUNIRKAA
97111 47426 Call Girls In Delhi MUNIRKAA97111 47426 Call Girls In Delhi MUNIRKAA
97111 47426 Call Girls In Delhi MUNIRKAAjennyeacort
 
Dwarka Sector 6 Call Girls ( 9873940964 ) Book Hot And Sexy Girls In A Few Cl...
Dwarka Sector 6 Call Girls ( 9873940964 ) Book Hot And Sexy Girls In A Few Cl...Dwarka Sector 6 Call Girls ( 9873940964 ) Book Hot And Sexy Girls In A Few Cl...
Dwarka Sector 6 Call Girls ( 9873940964 ) Book Hot And Sexy Girls In A Few Cl...rajnisinghkjn
 
Book Call Girls in Kasavanahalli - 7001305949 with real photos and phone numbers
Book Call Girls in Kasavanahalli - 7001305949 with real photos and phone numbersBook Call Girls in Kasavanahalli - 7001305949 with real photos and phone numbers
Book Call Girls in Kasavanahalli - 7001305949 with real photos and phone numbersnarwatsonia7
 
Housewife Call Girls Hsr Layout - Call 7001305949 Rs-3500 with A/C Room Cash ...
Housewife Call Girls Hsr Layout - Call 7001305949 Rs-3500 with A/C Room Cash ...Housewife Call Girls Hsr Layout - Call 7001305949 Rs-3500 with A/C Room Cash ...
Housewife Call Girls Hsr Layout - Call 7001305949 Rs-3500 with A/C Room Cash ...narwatsonia7
 
Call Girls Frazer Town Just Call 7001305949 Top Class Call Girl Service Avail...
Call Girls Frazer Town Just Call 7001305949 Top Class Call Girl Service Avail...Call Girls Frazer Town Just Call 7001305949 Top Class Call Girl Service Avail...
Call Girls Frazer Town Just Call 7001305949 Top Class Call Girl Service Avail...narwatsonia7
 
Pharmaceutical Marketting: Unit-5, Pricing
Pharmaceutical Marketting: Unit-5, PricingPharmaceutical Marketting: Unit-5, Pricing
Pharmaceutical Marketting: Unit-5, PricingArunagarwal328757
 
Call Girl Koramangala | 7001305949 At Low Cost Cash Payment Booking
Call Girl Koramangala | 7001305949 At Low Cost Cash Payment BookingCall Girl Koramangala | 7001305949 At Low Cost Cash Payment Booking
Call Girl Koramangala | 7001305949 At Low Cost Cash Payment Bookingnarwatsonia7
 
Kolkata Call Girls Services 9907093804 @24x7 High Class Babes Here Call Now
Kolkata Call Girls Services 9907093804 @24x7 High Class Babes Here Call NowKolkata Call Girls Services 9907093804 @24x7 High Class Babes Here Call Now
Kolkata Call Girls Services 9907093804 @24x7 High Class Babes Here Call NowNehru place Escorts
 
call girls in green park DELHI 🔝 >༒9540349809 🔝 genuine Escort Service 🔝✔️✔️
call girls in green park  DELHI 🔝 >༒9540349809 🔝 genuine Escort Service 🔝✔️✔️call girls in green park  DELHI 🔝 >༒9540349809 🔝 genuine Escort Service 🔝✔️✔️
call girls in green park DELHI 🔝 >༒9540349809 🔝 genuine Escort Service 🔝✔️✔️saminamagar
 
Russian Call Girls Chickpet - 7001305949 Booking and charges genuine rate for...
Russian Call Girls Chickpet - 7001305949 Booking and charges genuine rate for...Russian Call Girls Chickpet - 7001305949 Booking and charges genuine rate for...
Russian Call Girls Chickpet - 7001305949 Booking and charges genuine rate for...narwatsonia7
 
Call Girls Service in Virugambakkam - 7001305949 | 24x7 Service Available Nea...
Call Girls Service in Virugambakkam - 7001305949 | 24x7 Service Available Nea...Call Girls Service in Virugambakkam - 7001305949 | 24x7 Service Available Nea...
Call Girls Service in Virugambakkam - 7001305949 | 24x7 Service Available Nea...Nehru place Escorts
 
Russian Call Girls Gunjur Mugalur Road : 7001305949 High Profile Model Escort...
Russian Call Girls Gunjur Mugalur Road : 7001305949 High Profile Model Escort...Russian Call Girls Gunjur Mugalur Road : 7001305949 High Profile Model Escort...
Russian Call Girls Gunjur Mugalur Road : 7001305949 High Profile Model Escort...narwatsonia7
 
Call Girls Jp Nagar Just Call 7001305949 Top Class Call Girl Service Available
Call Girls Jp Nagar Just Call 7001305949 Top Class Call Girl Service AvailableCall Girls Jp Nagar Just Call 7001305949 Top Class Call Girl Service Available
Call Girls Jp Nagar Just Call 7001305949 Top Class Call Girl Service Availablenarwatsonia7
 
Noida Sector 135 Call Girls ( 9873940964 ) Book Hot And Sexy Girls In A Few C...
Noida Sector 135 Call Girls ( 9873940964 ) Book Hot And Sexy Girls In A Few C...Noida Sector 135 Call Girls ( 9873940964 ) Book Hot And Sexy Girls In A Few C...
Noida Sector 135 Call Girls ( 9873940964 ) Book Hot And Sexy Girls In A Few C...rajnisinghkjn
 
See the 2,456 pharmacies on the National E-Pharmacy Platform
See the 2,456 pharmacies on the National E-Pharmacy PlatformSee the 2,456 pharmacies on the National E-Pharmacy Platform
See the 2,456 pharmacies on the National E-Pharmacy PlatformKweku Zurek
 
Call Girls Hosur Just Call 7001305949 Top Class Call Girl Service Available
Call Girls Hosur Just Call 7001305949 Top Class Call Girl Service AvailableCall Girls Hosur Just Call 7001305949 Top Class Call Girl Service Available
Call Girls Hosur Just Call 7001305949 Top Class Call Girl Service Availablenarwatsonia7
 
Russian Call Girl Brookfield - 7001305949 Escorts Service 50% Off with Cash O...
Russian Call Girl Brookfield - 7001305949 Escorts Service 50% Off with Cash O...Russian Call Girl Brookfield - 7001305949 Escorts Service 50% Off with Cash O...
Russian Call Girl Brookfield - 7001305949 Escorts Service 50% Off with Cash O...narwatsonia7
 
Call Girls Hebbal Just Call 7001305949 Top Class Call Girl Service Available
Call Girls Hebbal Just Call 7001305949 Top Class Call Girl Service AvailableCall Girls Hebbal Just Call 7001305949 Top Class Call Girl Service Available
Call Girls Hebbal Just Call 7001305949 Top Class Call Girl Service Availablenarwatsonia7
 
Mumbai Call Girls Service 9910780858 Real Russian Girls Looking Models
Mumbai Call Girls Service 9910780858 Real Russian Girls Looking ModelsMumbai Call Girls Service 9910780858 Real Russian Girls Looking Models
Mumbai Call Girls Service 9910780858 Real Russian Girls Looking Modelssonalikaur4
 
Call Girls Jayanagar Just Call 7001305949 Top Class Call Girl Service Available
Call Girls Jayanagar Just Call 7001305949 Top Class Call Girl Service AvailableCall Girls Jayanagar Just Call 7001305949 Top Class Call Girl Service Available
Call Girls Jayanagar Just Call 7001305949 Top Class Call Girl Service Availablenarwatsonia7
 

Recently uploaded (20)

97111 47426 Call Girls In Delhi MUNIRKAA
97111 47426 Call Girls In Delhi MUNIRKAA97111 47426 Call Girls In Delhi MUNIRKAA
97111 47426 Call Girls In Delhi MUNIRKAA
 
Dwarka Sector 6 Call Girls ( 9873940964 ) Book Hot And Sexy Girls In A Few Cl...
Dwarka Sector 6 Call Girls ( 9873940964 ) Book Hot And Sexy Girls In A Few Cl...Dwarka Sector 6 Call Girls ( 9873940964 ) Book Hot And Sexy Girls In A Few Cl...
Dwarka Sector 6 Call Girls ( 9873940964 ) Book Hot And Sexy Girls In A Few Cl...
 
Book Call Girls in Kasavanahalli - 7001305949 with real photos and phone numbers
Book Call Girls in Kasavanahalli - 7001305949 with real photos and phone numbersBook Call Girls in Kasavanahalli - 7001305949 with real photos and phone numbers
Book Call Girls in Kasavanahalli - 7001305949 with real photos and phone numbers
 
Housewife Call Girls Hsr Layout - Call 7001305949 Rs-3500 with A/C Room Cash ...
Housewife Call Girls Hsr Layout - Call 7001305949 Rs-3500 with A/C Room Cash ...Housewife Call Girls Hsr Layout - Call 7001305949 Rs-3500 with A/C Room Cash ...
Housewife Call Girls Hsr Layout - Call 7001305949 Rs-3500 with A/C Room Cash ...
 
Call Girls Frazer Town Just Call 7001305949 Top Class Call Girl Service Avail...
Call Girls Frazer Town Just Call 7001305949 Top Class Call Girl Service Avail...Call Girls Frazer Town Just Call 7001305949 Top Class Call Girl Service Avail...
Call Girls Frazer Town Just Call 7001305949 Top Class Call Girl Service Avail...
 
Pharmaceutical Marketting: Unit-5, Pricing
Pharmaceutical Marketting: Unit-5, PricingPharmaceutical Marketting: Unit-5, Pricing
Pharmaceutical Marketting: Unit-5, Pricing
 
Call Girl Koramangala | 7001305949 At Low Cost Cash Payment Booking
Call Girl Koramangala | 7001305949 At Low Cost Cash Payment BookingCall Girl Koramangala | 7001305949 At Low Cost Cash Payment Booking
Call Girl Koramangala | 7001305949 At Low Cost Cash Payment Booking
 
Kolkata Call Girls Services 9907093804 @24x7 High Class Babes Here Call Now
Kolkata Call Girls Services 9907093804 @24x7 High Class Babes Here Call NowKolkata Call Girls Services 9907093804 @24x7 High Class Babes Here Call Now
Kolkata Call Girls Services 9907093804 @24x7 High Class Babes Here Call Now
 
call girls in green park DELHI 🔝 >༒9540349809 🔝 genuine Escort Service 🔝✔️✔️
call girls in green park  DELHI 🔝 >༒9540349809 🔝 genuine Escort Service 🔝✔️✔️call girls in green park  DELHI 🔝 >༒9540349809 🔝 genuine Escort Service 🔝✔️✔️
call girls in green park DELHI 🔝 >༒9540349809 🔝 genuine Escort Service 🔝✔️✔️
 
Russian Call Girls Chickpet - 7001305949 Booking and charges genuine rate for...
Russian Call Girls Chickpet - 7001305949 Booking and charges genuine rate for...Russian Call Girls Chickpet - 7001305949 Booking and charges genuine rate for...
Russian Call Girls Chickpet - 7001305949 Booking and charges genuine rate for...
 
Call Girls Service in Virugambakkam - 7001305949 | 24x7 Service Available Nea...
Call Girls Service in Virugambakkam - 7001305949 | 24x7 Service Available Nea...Call Girls Service in Virugambakkam - 7001305949 | 24x7 Service Available Nea...
Call Girls Service in Virugambakkam - 7001305949 | 24x7 Service Available Nea...
 
Russian Call Girls Gunjur Mugalur Road : 7001305949 High Profile Model Escort...
Russian Call Girls Gunjur Mugalur Road : 7001305949 High Profile Model Escort...Russian Call Girls Gunjur Mugalur Road : 7001305949 High Profile Model Escort...
Russian Call Girls Gunjur Mugalur Road : 7001305949 High Profile Model Escort...
 
Call Girls Jp Nagar Just Call 7001305949 Top Class Call Girl Service Available
Call Girls Jp Nagar Just Call 7001305949 Top Class Call Girl Service AvailableCall Girls Jp Nagar Just Call 7001305949 Top Class Call Girl Service Available
Call Girls Jp Nagar Just Call 7001305949 Top Class Call Girl Service Available
 
Noida Sector 135 Call Girls ( 9873940964 ) Book Hot And Sexy Girls In A Few C...
Noida Sector 135 Call Girls ( 9873940964 ) Book Hot And Sexy Girls In A Few C...Noida Sector 135 Call Girls ( 9873940964 ) Book Hot And Sexy Girls In A Few C...
Noida Sector 135 Call Girls ( 9873940964 ) Book Hot And Sexy Girls In A Few C...
 
See the 2,456 pharmacies on the National E-Pharmacy Platform
See the 2,456 pharmacies on the National E-Pharmacy PlatformSee the 2,456 pharmacies on the National E-Pharmacy Platform
See the 2,456 pharmacies on the National E-Pharmacy Platform
 
Call Girls Hosur Just Call 7001305949 Top Class Call Girl Service Available
Call Girls Hosur Just Call 7001305949 Top Class Call Girl Service AvailableCall Girls Hosur Just Call 7001305949 Top Class Call Girl Service Available
Call Girls Hosur Just Call 7001305949 Top Class Call Girl Service Available
 
Russian Call Girl Brookfield - 7001305949 Escorts Service 50% Off with Cash O...
Russian Call Girl Brookfield - 7001305949 Escorts Service 50% Off with Cash O...Russian Call Girl Brookfield - 7001305949 Escorts Service 50% Off with Cash O...
Russian Call Girl Brookfield - 7001305949 Escorts Service 50% Off with Cash O...
 
Call Girls Hebbal Just Call 7001305949 Top Class Call Girl Service Available
Call Girls Hebbal Just Call 7001305949 Top Class Call Girl Service AvailableCall Girls Hebbal Just Call 7001305949 Top Class Call Girl Service Available
Call Girls Hebbal Just Call 7001305949 Top Class Call Girl Service Available
 
Mumbai Call Girls Service 9910780858 Real Russian Girls Looking Models
Mumbai Call Girls Service 9910780858 Real Russian Girls Looking ModelsMumbai Call Girls Service 9910780858 Real Russian Girls Looking Models
Mumbai Call Girls Service 9910780858 Real Russian Girls Looking Models
 
Call Girls Jayanagar Just Call 7001305949 Top Class Call Girl Service Available
Call Girls Jayanagar Just Call 7001305949 Top Class Call Girl Service AvailableCall Girls Jayanagar Just Call 7001305949 Top Class Call Girl Service Available
Call Girls Jayanagar Just Call 7001305949 Top Class Call Girl Service Available
 

Drug interaction.pptx

  • 1. BY ASAWE TEJASWINI L DEPARTMENT OF PHARMACOLOGY ASSIASTANT PROFESSOR SIDHHIS INSTITUTE OF PHARMACY THANE Drug Interaction
  • 2. • A drug interaction has occurred when administration of one drug alters the clinical effects of another . • A drug interaction results when the effects of a drug are altered in some way by the presence of another drug, by food, or by environmental exposure. • A drug–drug interaction increases with the number of medications a patient is receiving can cause risk of developing an adverse drug reaction (ADR). Drug interaction
  • 3.
  • 4. Drug – Drug Interaction  A reaction between two or more drugs.  This can involve prescription medications , over the counter medicine (OTC) and herbs, vitamins , and supplements.  Taking a drug while having certain medical conditions can also cause a drug interaction.  For example, taking a nasal decongestant if you have high blood pressure may cause an unwanted reaction.  Warfarin ( prevent blood clots) with acetylsalicylic acid (anti-inflammatory) may increase the risk of bleeding.
  • 5.  A drug-drug interaction (DDI) occurs when the clinical effect of a given drug is altered by the action of another drug.  Importantly, drug interactions contribute to the majority of adverse drug reactions, and approximately 70% of interactions are clinically relevant.
  • 6. Drug Food Interaction  When food or beverage intake alters a drugs effect.  If someone taking certain statins atorvastatin , rosuvastatin to lower cholesterol & drinks a lot of grapefruit juice can cause too much of drug in body.  This may increase their risk for liver damage or kidney failure.  Ex. ANTIBIOTICS with milk products that complex with some antibiotics and prevent their absorption. reduced bioavailability
  • 7. Drug – Alcohol Interaction  Certain medication should not be taken with alcohol.  Combination of alcohol with drugs can cause tiredness and delayed reactions, can also your risk for negative side effects.  Ex. drug interaction between warfarin and alcohol, which could increase bleeding risk.  medications can interact with alcohol, including antibiotics, antidepressants, muscle relaxants, anti-inflammatory agents and warfarin.
  • 8. Drug - Disease Interaction  The drugs that alters or worsen a condition or disease.  Ex. taking a nasal decongestant for cold can increase blood pressure .  This is potentially dangerous dangerous interaction for people with high blood pressure may cause an unwanted reaction.
  • 9. Drug Laboratory Interaction  Medication interferes with laboratory test.  This can result in inaccurate test.  For example, cephalosporin's may alter urine glucose and ketone tests.  Certain antidepressants have been shown to interfere with skin prick test used to determine allegy.
  • 10. DRUG INTERACTION PHARMACEUTICAL (OUTSIDE THE BODY ) PHARMACOLOGICAL (INSIDE THE BODY PHYSICAL CHEMICAL PHARMACODYNA MIC PHARMACOKINE TIC ANTAGONIS T ADDITIVE SYNERGIST IC ABSORPTIO N DISTRIBUTIO N METABOLIS M EXCRETION
  • 11. Pharmaceutical Interaction  Pharmaceutical interaction can be divided into chemical and physical reaction.  A chemical reaction is occurs due to the incompatibility between two drugs administered at the same time.  Ex. phenytoin and lorazepam become ineffective if mixed together in the same IV bag or syringe.  Physical reaction occurs when physically altering a drug formulation such as by crushing a sustained release tablet , drug release more quickly and in large amount.
  • 12. Pharmacological Interaction  Pharmacological Interaction most commonly occurring in drug -drug interaction.  Pharmacological interaction are classified as pharmacodynamic & pharmacokinetic interaction .  Pharmacokinetic interactions results from alteration in a drugs absorption , distribution , metabolism and excretion characteristics.
  • 13. Pharmacodynamic interactions  Pharmacodynamic interactions are those in which one drug influence each others effect directly .  Such interactions are of particular importance when chemotherapy drugs that are nephrotoxic are combined.  An additive Pharmacodynamic effect when two or more drugs with similar Pharmacodynamic effect are given , the additive effect may result in excessive response and toxicity .  additive Pharmacodynamic effect When on the kidneys can lead to mild-to-moderate renal failure.  Antagonistic Pharmacodynamic effect may reduce response to one or both drug .  Ex when acetylsalicylic acid combined with ibuprofen it reduced the drug effect .
  • 14. Pharmacokinetic interaction  pharmacokinetic interaction occurs when one medication alters the absorption, distribution, metabolism, or excretion of another.  The effect of other drugs or non medicinal products on the amount of chemotherapeutic drug absorbed is especially important in the case of orally administered drugs.  Food intake may increase or decrease these drugs' absorption.  For example, it is important that capecitabine be taken within 30 minutes after a meal.  The safety of capecitabine taken on an empty stomach has not been established.  When pharmacists dispense prescriptions for these agents, it is essential that they make patients aware of the effect or food or drugs.
  • 15. How can a person avoid drug interactions?  You can take the following steps to avoid drug interactions:  Tell your health care provider about all prescription and nonprescription medicines you are taking or plan to take.  Also tell your health care provider about any vitamins, nutritional supplements, and herbal products you take.  Tell your health care provider about any other conditions you may have, such as high blood pressure or diabetes.  Take medicines according to your health care provider's instructions.  Always read the information and directions that come with a medicine.