Prostaglandins are lipid compounds derived from arachidonic acid that have diverse hormone-like effects. They were first isolated from seminal fluid in 1935 and are produced by many tissues. Prostaglandins play important roles in reproduction, including conception, menstruation, and childbirth. They also have effects on smooth muscle contraction, platelet aggregation, gastric secretion, and more. Prostaglandins have potential therapeutic uses such as induction of labor and treatment of infertility or menstrual cramps.

1. Presented by
MD TANIM BIN ZAMAN-2135141670

2. Prostaglandins Introduction
 The prostaglandins (PG) are a group of physiologically
active lipid compounds called eicosanoids having diverse
hormone-like effects in animals
 Prostaglandins and their related compounds like
prostacyclins(PGI),thromboxanes(TXA),leukotrienes(LT),
Lipoxins are collectively known as eicosanoids.They all
contain 20C
 They are derived enzymatically from the fatty acid
arachidonic acid. Prostaglandins are lipid autacoids
derived from arachidonic acid.

3. Biosynthesis

4. History
 The name prostaglandin derives from the prostate gland,
chosen when prostaglandin was first isolated from seminal
fluid in 1935 by the Swedish physiologist Ulf von Euler,
and independently by the Irish-English physiologist
Maurice Walter Goldblatt (1895–1967)
 Systematic studies of prostaglandins commenced in 1930,
when Kurzrock and Lieb noted the fascinating finding that
uteri from patients who had gone through successful
pregnancies responded to the fluid with relaxation,while
uteri from sterile women responded with contraction upon
addition of this seminal fluid

5. History
 Prostaglandins were believed to be part of the prostatic
secretions, and eventually were discovered to be
produced by the seminal vesicles.
 Later, it was shown that many other tissues secrete
prostaglandins and that they perform a variety of
functions.
 The first total syntheses of prostaglandin F2α and
prostaglandin E2 were reported by E. J. Corey in
1969,[9] an achievement for which he was awarded the
Japan Prize in 1989

6. General structure of Prostaglandins

7. Types and Functions

8. Biological activities and functions
 Prostaglandins play a role in the following reproductive
functions: 1) conception; 2) luteolysis; 3) menstruation; and 4)
parturition.
 Research on the physiopathologic and biochemical nature of
prostaglandins (PGs) suggests that PGs play a role in
reproductive physiology.
 In vitro studies show that the PGE series decrease the motility of
the human uterus, fallopian tubes, and ureter, and produce
vasodilatation
 PGs are also known to inhibit lipolysis, platelet aggregation, and
gastric secretion
 PGs have therapeutic potentials in induction of labor, treatment
of infertility, morning-after conception, treatment of
dysmenorrhea, and contraception by alteration of fallopian tube
motility.

9. Roles of Prostaglandins on cell
gowth and divison
 Prostaglandin E2 enhances hematopoietic stem cell
homing, survival, and proliferation
 Prostaglandin F2 stimulates growth of skeletal muscle
Cells via an NFATC2-dependent pathway
 Prostaglandin E2 Promotes Features of Replicative
Senescence in Chronically Activated Human CD8+ T
Cells
 Prostaglandins E1 and E2 Interact with Prostaglandin F2α
to Regulate Initiation of DNA Replication and Cell
Division in Swiss 3T3 Cell

10. Conclusion