Three Interreg MED projects - COWORKMed, CreativeWear, and ProminentMED - showcase how Knowledge Champions can promote inclusive innovation in different ways. COWORKMed advocates for inclusive innovation and territorial proximity through co-working spaces. CreativeWear enhances cognitive, social, and spatial proximity dimensions through innovation hubs. ProminentMED advocates its public procurement model and creates a trans-local network through direct support. The brief provides tips for policymakers to encourage the emergence of Knowledge Champions, leverage their actions towards inclusive innovation, and promote transnational knowledge flows and territorial receptivity.