Lead from natural products cannabinoids as anticancer

1. Lead from natural product
Cannabinoids as an anticancer
by: swati wadhawan
m.pharm 1st year
mdu, rohtak

2. INTRODUCTION
• Cannabinoids are obtained from the flowering tops of
the plant Cannabies sativum belonging to
the family Cannabeaceae.
• The study of chemical components
produced by Cannabis started in
1960’s. Today, it is widely accepted
that there are over 70 different
types of Cannabinoids are present
in C. sativa.

3. Major Types Of Cannabinoids
• CBGA (Cannabigerolic acid)
• THCA (Δ9-tetrahydrocannabinolic acid)
• CBDA (Cannabidiolic acid)
• CBCA (Cannabichromenenic acid)
• CBGVA (Cannabigerovarinic acid)
• THCVA (Tetrahydrocanabivarinic acid)
• CBDVA (Cannabidivarinic acid)
• CBCVA (Cannabichromevarinic acid)

4. Isolation Of Cannabinoids
• The cannabniods were extracted by aqueous extract
found a total yield of 3.8g while as acetone extract
4.8g.
• The extract should be isolated by using HPLC (high
performance liquid chromatography) technique.

5. Cannabinoid With Anticancer
Property
• Δ9-tetrahydrocannabinol (THC) and Cannabidiol (CBD)
the main active component of Cannabis sativa having the
anticancer property.
• Two major cannabinoid-specific receptors – CB1 and
CB2 – have been identified

6. Anticancer Study On Cannabinoid
• The various study relative to the role of
endocannabinoid system in tumor generation and
progression, during the last fifteen years shown that
cannabinoids have the anticancer and antitumorigenic
effect on animal models.
• A tumor-promoting effect of cannabinoids has been
proposed in few reports Cannabinoid treatment
promotes cancer cell death, impair tumor angiogenesis
and block invasion and Metastasis.

7. MOA Of Cannabinoids
General mod of action of cannabinods as an anti cancer agent

8. Continue…..
Cannabinoids block tumor progression by targeting several
hallmarks of cancer. They impair uncontrolled cancer cell
growth by inducing cancer cell death by apoptosis and by
inhibiting cancer cell proliferation. They also hamper
tumor angiogenesis by down regulating the vascular
endothelial growth factor (VEGF) pathway in cancer cells.

9. Comparative Study Of Cannabinoids
With Other Anticancer
• Cannabinoids and their derivatives exert palliative effects
in cancer patients by preventing nausea, vomiting and
pain and by stimulating appetite while other anticancer
treatment may cause nausea, vomiting and pain as an
adverse effect.
• Cannabinoids are usually well tolerated, and do not
produce the generalized toxic effects of conventional
chemotherapies.

10. Side Effects Of Cannabinoids
• Dizziness was the most common adverse effect of
cannabinoids
• Relapse of multiple sclerosis, vomiting and urinary
tract infection
• It may also causes dry mouth
• Reduces blood pressure

11. Conclusions And Future Directions
• Aimed at reducing mortality from cancer should
consist of targeted therapies capable of providing the
most efficacious and selective treatment for each
individual tumor and patient
• THC inhibits tumor growth in animal models through
a well-established mechanism of action that also
seems to operate in human patients. Moreover,
cannabinoids potentiate the antitumor efficacy in
mice .

12. Continue…..
• However, further research is required to define the
precise molecular cross-talk between cannabinoids
and chemotherapeutic drugs and to optimize the
pharmacology of preclinical cannabinoid-based
combination therapies.
• cannabinoids show an acceptable safety profile,
clinical trials testing them as single drugs or, ideally,
in combination therapies.

13. References
• https://www.ncbi.nlm.nih.gov
• https://www.nature.com
• https://www.jscimedcentral.com/Urology/urology-4-
1090.pdf
• https://www.jscimedcentral.com/Urology/urology-4-
1090.pdf
• https://www.sciencedirect.com/science/article/pii/S02
78584615001190