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SISTEMIK LUPUS ERITEMATOSUS
1
Presentation
Title
Gambaran kemerahan spt kupu-kupu, "butterfly rash” (von Hebra, 1846)
(“peniru ulung” = “penyakit seribu wajah” = “the great imitator”)
(berbagai gejala yg menyerupai penyakit-penyakit lain)
Penemuan penyakit “LUPUS”
Laurent Biett (Perancis, th 1828)
Pertamakali melaporkan lupus sbg penyakit kulit
Dalam kedokteran disebut “Lupus Erythematosus”
(von Hebra, 1856)
Istilah “LUPUS” berasal dari bahasa Latin berarti “anjing hutan” atau
“serigala”.
Sedang kata “Erythematosus” dalam bahasa Yunani berarti “kemerah-
merahan”.
Penyakit kelainan kulit kemerahan di sekitar hidung & pipi,
disebabkan oleh gigitan anjing hutan/serigala.
2
Presentation
Title
Perkembangan Penemuan LUPUS
Moriz Kaposi (Australia, 1872)
Membedakan lupus Kulit dan Lupus Sitemik berdasarkan gambaran klinik
(demam, nodule di bawah kulit, anemia, penurunan BB,
pembesaran kelenjar getah bening)
Sir William Osler (USA, 1890)
Karena dapat menyerang organ tubuh bagian dalam, tanpa ada kelainan di kulit,
sehingga disebut Sistemik Lupus Eritematosus (SLE).
Dr. Malcolm Hargraves (Mayo di USA, 1948)
Menemukan sel yang khas dalam darah penderita SLE, disebut: “Sel LE”
Tahun 1957: pertamakali anti-DNA antibody SLE teridentifikasi
3
Presentation
Title
4
Presentation
Title
Epidemiologi
(Penderita Lupus = ODIPUS)
Secara global, diperkirakan terdapat 5 juta ODIPUS, 20 -150 kasus/100.000 org
(9 dari 10 penderita adalah PEREMPUAN, dan usia 15 - 44 th)
Di Indonesia jumlah ODIPUS yg tercatat mencapai 8.693 org
atau meningkat 2 kali dibandingkan dengan th 2004
(fenomena gunung es)
Kejadian 2-3 kali lebih sering pada ras Afrika, Asia, Hispanik, & Amerika asli.
Sejauh ini hanya 10% dari ODIPUS yg memiliki saudara dekat (orang tua atau
saudara) yang juga terkena atau mungkin terserang lupus
Hanya ± 5% bayi yang dilahirkan oleh ODIPUS kemungkinan terkena lupus
DEFINISI
Penyakit Lupus
Eritematosus
5
Presentation
Title
Adalah suatu kondisi yg
dikarakteristikkan oleh
peradangan kronis
dari jaringan-jaringan tubuh
yg disebabkan karena
kelainan sistim autoimun
(Penyakit Autoimun)

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Lupus.pptx

  • 1. SISTEMIK LUPUS ERITEMATOSUS 1 Presentation Title Gambaran kemerahan spt kupu-kupu, "butterfly rash” (von Hebra, 1846) (“peniru ulung” = “penyakit seribu wajah” = “the great imitator”) (berbagai gejala yg menyerupai penyakit-penyakit lain)
  • 2. Penemuan penyakit “LUPUS” Laurent Biett (Perancis, th 1828) Pertamakali melaporkan lupus sbg penyakit kulit Dalam kedokteran disebut “Lupus Erythematosus” (von Hebra, 1856) Istilah “LUPUS” berasal dari bahasa Latin berarti “anjing hutan” atau “serigala”. Sedang kata “Erythematosus” dalam bahasa Yunani berarti “kemerah- merahan”. Penyakit kelainan kulit kemerahan di sekitar hidung & pipi, disebabkan oleh gigitan anjing hutan/serigala. 2 Presentation Title
  • 3. Perkembangan Penemuan LUPUS Moriz Kaposi (Australia, 1872) Membedakan lupus Kulit dan Lupus Sitemik berdasarkan gambaran klinik (demam, nodule di bawah kulit, anemia, penurunan BB, pembesaran kelenjar getah bening) Sir William Osler (USA, 1890) Karena dapat menyerang organ tubuh bagian dalam, tanpa ada kelainan di kulit, sehingga disebut Sistemik Lupus Eritematosus (SLE). Dr. Malcolm Hargraves (Mayo di USA, 1948) Menemukan sel yang khas dalam darah penderita SLE, disebut: “Sel LE” Tahun 1957: pertamakali anti-DNA antibody SLE teridentifikasi 3 Presentation Title
  • 4. 4 Presentation Title Epidemiologi (Penderita Lupus = ODIPUS) Secara global, diperkirakan terdapat 5 juta ODIPUS, 20 -150 kasus/100.000 org (9 dari 10 penderita adalah PEREMPUAN, dan usia 15 - 44 th) Di Indonesia jumlah ODIPUS yg tercatat mencapai 8.693 org atau meningkat 2 kali dibandingkan dengan th 2004 (fenomena gunung es) Kejadian 2-3 kali lebih sering pada ras Afrika, Asia, Hispanik, & Amerika asli. Sejauh ini hanya 10% dari ODIPUS yg memiliki saudara dekat (orang tua atau saudara) yang juga terkena atau mungkin terserang lupus Hanya ± 5% bayi yang dilahirkan oleh ODIPUS kemungkinan terkena lupus
  • 5. DEFINISI Penyakit Lupus Eritematosus 5 Presentation Title Adalah suatu kondisi yg dikarakteristikkan oleh peradangan kronis dari jaringan-jaringan tubuh yg disebabkan karena kelainan sistim autoimun (Penyakit Autoimun)