Peer-graded Assignment: Final Project- Understanding the Brain, The Neurobiology of everyday life.

1. MOTOR NEURON DISEASE By,
Subikshaa V S

2. EXAMPLE OF NEUROBIOLOGY IN
EVERYDAY LIFE
My aunt’s name is Asha. She’s 47 years
old, and is suffering from primary lateral
sclerosis. She is the inspiration for me to
have enrolled for this course, and is my
example for this assignment.

3. WHAT IS MOTOR NEURON
DISORDER?
Motor neuron disorder is a neurodegenerative
disorder that destroys motor neurons, the cells that
regulate skeletal muscle action like walking, breathing,
speaking, and swallowing. Amyotrophic lateral
sclerosis (ALS), progressive bulbar palsy (PBP),
pseudobulbar palsy, progressive muscular atrophy
(PMA), primary lateral sclerosis (PLS), spinal muscular
atrophy (SMA), and monomelic amyotrophy (MMA), as
well as a few less common variations that resemble
ALS, are among them.

4. PRIMARY LATERAL
SCLEROSIS
It results in the
progressive failure of the
nerve cells in the brain
that govern movement.

5. WHAT IS PRIMARY LATERAL
SCLEROSIS?
It can result in movement issues like slower movement
and clumsiness, difficulty with balance, weakness, and
issues with swallowing and speaking when the central
nerve cells are unable to stimulate the motor neurons
in the spinal cord, which regulate voluntary muscles.
When hereditary spastic paraplegia or clinical signs of
lower motor neuron involvement are absent, primary
lateral sclerosis is also referred to as progressive
upper motor neuron dysfunction.

6. WHAT ARE THE SYMPTOMS?
The symptoms that my aunt had are:
•Weakness and stiffness in the legs
•Slow movement
•Tripping or problem in balancing
•Difficulty in breathing

7. THE FUNCTIONS OF THE NERVOUS SYSTEM
THAT ARE IMPAIRED IN PRIMARY LATERAL
SCLEROSIS
The part that is mainly affected in primary lateral sclerosis are
the neurons of the motor cortex, which extend to the brain
stem or spinal cord. Voluntary movement is regulated by the
frontal lobes' primary motor cortex. This region of the brain can
govern muscular movements because it contains nerve
connections to the spinal cord. The primary motor cortex, each
of which is connected to a distinct region of the motor cortex,
regulates movement in different parts of the body.

8. HOW IS PRIMARY LATERAL SCLEROSIS
TREATED?
•medications that lessen muscular stiffness.
•Physical treatment that helps increase muscular
flexibility.
•equipment to help with mobility, such as a wheelchair.

9. THE WAYS IN WHICH THIS COURSE HAS
ALLOWED ME TO BETTER ANALYZE THE
PHENOMENA AROUND ME
This course has helped me understand the basic
neurobiology of the brain, it’s different parts, and how
it works. I understood the complexity of the brain’s
functioning and how it regulates the functioning of
other organs of the body also. I also got to know about
the various disorders that occur in the CNS, and about
the problems and cause of the disease my aunt is
suffering from.

10. THANK YOU.