1. Cell death, Apoptosis and
Necrosis – Case based discussion
Dr VK Iyer
Prof and Head
Dept of Pathology
AIIMS, New Delhi
Dr Balamurugan T
Assistant Professor
Dept of Pathology
AIIMS, New Delhi
2. Case 1
• A young child presented with cervical lymph node enlargement since
2 weeks
• No loss of weight/appetite
• Cervical lymph node excision done
4. Case 2
• A 24 year old female patient presented with painless enlargement of
axillary lymph node
• She had fever, weakness and weight loss
• Core biopsy of lymph node was done
• HE, CD3 and CD20 slide provided
6. Case 3
• An elderly gentleman presents with bloody stools and abdominal pain
• Colonoscopy reveals multiple ulcers
• He has received stem cell transplant two months back for multiple
myeloma
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7. Case 4
• A 35-year-old female presented with insidious onset fatigue and gradually progressive jaundice. She
is non-alcoholic. Baseline investigations are given below:
• LFT: Bilirubin – 27 μmol/L (N: 1-20); indirect> direct
• AST – 751 U/L (N: 5-30)
• ALT – 536 U/L (N: 5 -35)
• ALP – 140 U/L (N: 30-110)
• GGT – 30 U/L (N: 5-35)
• Serum total cholesterol – 4.0 mmol/L (N: <5.2)
• Serum triglyceride – 1.5 mol/L (N: <1.69)
• ANA – Positive (titer 1: 160 by IIF)
• HBV, HCV and HIV serology – Negative
• USG: Liver echotexture normal
• Within few days of admission, the patient developed liver failure
9. Case 5
• A 30 year old female presented with ulcer in hard palate and rapidly
increasing facial swelling
• On examination, the mucosa was ulcerated and necrotic. HE and IHCs
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10. Case 6
• A 50 year old male presented with symptoms of nasal obstruction and
bloody nasal discharge
• On examination, an ulcero-proliferative tumour was noted
HE and other IHCs
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