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By
Dr Waleed Al-Tuwairqi, MD
Elite Medical & Surgical Center
Riyadh -KSA

7th International Congress
Of Corneal Cross-Linking
            2011




                                  1
‫بسم ال الرحمن الرحيم‬
In the name of Allah, Most Gracious, Most Merciful
   Saudi Desert                          Mecca




   Riyadh                                 Elite




                                                     2
 Selecting the right patient for ICR
 Observing post-op results for 6-12 months
 Enhancing post-ICR results with PRK+CXL
 Reviewing the results of this approach



         7th International Congress of Corneal Cross-Linking
                                                               3
KC
                   Terminal

           KC Advanced - CS

         KC Moderate - ICS

         KC Moderate - BSV

            KC Early - GSV

           KC Suspect - ESV

7th International Congress of Corneal Cross-Linking
                                                      4
1.   BSCVA                                      20/20 or better

2.   Corneal Coma                               < 0.5um

3.   Post. Elevation                            < 15um

4.   UNCVA for Near                             J1 or Better
5.   Subjectively                               Patient easily can drive at night

6.   Max K                                       < 48 D


              7th International Congress of Corneal Cross-Linking
                                                                                    5
1.   BSCVA                                      20/25 or better

2.   Corneal Coma                               < 1.5um

3.   Post. Elevation                            < 40um

4.   UNCVA for Near                             J2 or Better

5.   Subjectively                               Patient can drive at night

6.   Max K                                      < 51 D

              7th International Congress of Corneal Cross-Linking
                                                                             6
1.   BSCVA                                      20/40 or better

2.   Corneal Coma                               1.5-4.0um

3.   Post. Elevation                            > 40um

4.   UNCVA for Near                             J2 or Worse
5.   Subjectively                               Night vision difficulty

6.   Max K                                       48-55 D


              7th International Congress of Corneal Cross-Linking
                                                                          7
1.   BSCVA                                      20/50 or less

2.   Corneal Coma                               > 4um

3.   Post. Elevation                            > 60um

4.   UNCVA for Near                             J3 or Less

5.   Subjectively                               Symptomatic

6.   Max K                                      > 60 D

7.   Cone Dimension                             3*3 or 5*5
              7th International Congress of Corneal Cross-Linking
                                                                    8
G.S.V.                     B.S.V.                               I.C.S.

                    ICR (B.S.V.  G.S.V.)
PRK+CXL
                                  &
   Or                                                             ?
                           PRK+CXL
ICL+CXL
          (Irregular central cornea  Regular central cornea)
          7th International Congress of Corneal Cross-Linking
                                                                         9
7th International Congress of Corneal Cross-Linking
                                                      10
12
  OD                   6          KC                   11
  OS                   6          Post-Lasik Ectasia   1
  Eyes               12           Eyes                 12

7th International Congress of Corneal Cross-Linking
                                                            11
Mean                          30 y              Males         11

Minimum                       16 y              Females       1

Maximum                                         Eyes          12
                              43 y
Count                        12 E


        7th International Congress of Corneal Cross-Linking
                                                                   12
25Y. M. OS




                     Pre-ICR




                    Post-ICR




                Post-PRK+ CXL

7th International Congress of Corneal Cross-Linking
                                                      13
31Y. M. OS




                     Pre-ICR




                    Post-ICR




                  Post-PRK+ CXL
7th International Congress of Corneal Cross-Linking
                                                      14
31Y. M. OD




                     Pre-ICR




             Minor
                Post-ICR

            Change


                  Post-PRK+ CXL
7th International Congress of Corneal Cross-Linking
                                                      15
28Y. M. OD
                      (Post-Lasik Ectasia)




                     Pre-ICR




                      Post-ICR




                   Post-PRK+ CXL
7th International Congress of Corneal Cross-Linking
                                                      16
38Y. M. OS




                      Pre-ICR




                     Post-ICR




                   Post-PRK+ CXL

7th International Congress of Corneal Cross-Linking
                                                      17
38Y. M. OD




                     Pre-ICR




                      Post-ICR




                 Post-PRK+ CXL
7th International Congress of Corneal Cross-Linking
                                                      18
43Y. M. OS




                     Pre-ICR




                      Post-ICR




                 Post-PRK+ CXL
7th International Congress of Corneal Cross-Linking
                                                      19
26Y. M. OD




                      Pre-ICR




                      Post-ICR




                 Post-PRK+ CXL
7th International Congress of Corneal Cross-Linking
                                                      20
21Y. M. OS




                     Pre-ICR




                     Post-ICR




                Post-PRK+ CXL
7th International Congress of Corneal Cross-Linking
                                                      21
16Y. M. OS




                       Post-ICR




                      Pre-ICR




                   Post-PRK+ CXL

7th International Congress of Corneal Cross-Linking
                                                      22
25Y. M OD




                      Pre-ICR




                      Post-ICR




                Post-PRK+ CXL
7th International Congress of Corneal Cross-Linking
                                                      23
Pre-ICR         Post-ICR        Post-PRK-CXL
7th International Congress of Corneal Cross-Linking
Pre-ICR         Post-ICR        Post-PRK-CXL
7th International Congress of Corneal Cross-Linking
Pre-ICR        Post-ICR         Post-PRK-CXL
7th International Congress of Corneal Cross-Linking
Pre-ICR   Post-ICR   Post-PRK-CXL
Pre-ICR          Post-ICR         Post-PRK-CXL

7th International Congress of Corneal Cross-Linking
Pre-ICR   Post-ICR   Post-PRK-CXL
Pre-ICR   Post-ICR   Post-PRK-CXL
Pre-ICR   Post-ICR   Post-PRK-CXL
Pre-ICR   Post-ICR   Post-PRK-CXL
Difference between   Difference between     Difference between
Factor              Pre-ICR & Post-ICR   Post-ICR &             Pre-ICR &
                                         Post-PRK+CXL           Post-PRK +CXL

UNCVA                     0.38                  0.23                  0.61
                         (0.1 - 0.35)           ( 0 - 0.3)           (0.1 - 0.65)

BCVA                      0.09                  0.10                  0.19
                         (-0.2 -0.2)            (0 - 0.3)            (-0.2 -0.5)

Spherical               -3.06D               -1.81D                 -4.88D
Equivalent (S.E.)        (1.12 - 6.5)          (-2.78 - 1)           (-1.75 - 7.5)

Corneal                 -1.88D               -0.02D                 -1.90D
Astigmatism              (0.7 - 6.24)        (0.07 - (-0.24))        (0.46 - 6.17)

Max K                    3.23D                3.01D                  6.25D
                         (1.96 - 5.73)        (2.13-3.79)            (5.75 - 7.86)

Average K                2.33D                3.56D                  5.88D
                        (1.57 – 5.19)        (3.47 – 5.58)          (5.04 – 10.77)

Coma                      0.66                  0.32                  0.98
                          (0.4-0.64)           (-0.2 - 1.0)           (0.2-1.64)

Ablation Depth                                60um
                                               (27 – 125)
 Based on our review, ICR followed later by
   PRK+CXL is an effective & safe approach in
   making a functional change in the life style of
   cases of moderate KC
 We recommend to be done for the following
   group of patients …..

            7th International Congress of Corneal Cross-Linking
                                                                  34
1. MAX K                                             55D or less
2. Sphere                                            -6D
3. Coma                                              1.5-4.0 u
4. Post. Elevation                                   >??
5. Pachymetry                                        450 u or more
6. Clarity                                           Clear cornea
7. Gain of lines                                     2 lines or more
                                                     (expect to achieve in 2nd step)


             7th International Congress of Corneal Cross-Linking
                                                                                       35
Saudi Desert   Mecca




Riyadh          Elite




                        36

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Presentation: Two step approach to Keratoconus

  • 1. By Dr Waleed Al-Tuwairqi, MD Elite Medical & Surgical Center Riyadh -KSA 7th International Congress Of Corneal Cross-Linking 2011 1
  • 2. ‫بسم ال الرحمن الرحيم‬ In the name of Allah, Most Gracious, Most Merciful Saudi Desert Mecca Riyadh Elite 2
  • 3.  Selecting the right patient for ICR  Observing post-op results for 6-12 months  Enhancing post-ICR results with PRK+CXL  Reviewing the results of this approach 7th International Congress of Corneal Cross-Linking 3
  • 4. KC Terminal KC Advanced - CS KC Moderate - ICS KC Moderate - BSV KC Early - GSV KC Suspect - ESV 7th International Congress of Corneal Cross-Linking 4
  • 5. 1. BSCVA 20/20 or better 2. Corneal Coma < 0.5um 3. Post. Elevation < 15um 4. UNCVA for Near J1 or Better 5. Subjectively Patient easily can drive at night 6. Max K < 48 D 7th International Congress of Corneal Cross-Linking 5
  • 6. 1. BSCVA 20/25 or better 2. Corneal Coma < 1.5um 3. Post. Elevation < 40um 4. UNCVA for Near J2 or Better 5. Subjectively Patient can drive at night 6. Max K < 51 D 7th International Congress of Corneal Cross-Linking 6
  • 7. 1. BSCVA 20/40 or better 2. Corneal Coma 1.5-4.0um 3. Post. Elevation > 40um 4. UNCVA for Near J2 or Worse 5. Subjectively Night vision difficulty 6. Max K 48-55 D 7th International Congress of Corneal Cross-Linking 7
  • 8. 1. BSCVA 20/50 or less 2. Corneal Coma > 4um 3. Post. Elevation > 60um 4. UNCVA for Near J3 or Less 5. Subjectively Symptomatic 6. Max K > 60 D 7. Cone Dimension 3*3 or 5*5 7th International Congress of Corneal Cross-Linking 8
  • 9. G.S.V. B.S.V. I.C.S. ICR (B.S.V.  G.S.V.) PRK+CXL & Or ? PRK+CXL ICL+CXL (Irregular central cornea  Regular central cornea) 7th International Congress of Corneal Cross-Linking 9
  • 10. 7th International Congress of Corneal Cross-Linking 10
  • 11. 12 OD 6 KC 11 OS 6 Post-Lasik Ectasia 1 Eyes 12 Eyes 12 7th International Congress of Corneal Cross-Linking 11
  • 12. Mean 30 y Males 11 Minimum 16 y Females 1 Maximum Eyes 12 43 y Count 12 E 7th International Congress of Corneal Cross-Linking 12
  • 13. 25Y. M. OS Pre-ICR Post-ICR Post-PRK+ CXL 7th International Congress of Corneal Cross-Linking 13
  • 14. 31Y. M. OS Pre-ICR Post-ICR Post-PRK+ CXL 7th International Congress of Corneal Cross-Linking 14
  • 15. 31Y. M. OD Pre-ICR Minor Post-ICR Change Post-PRK+ CXL 7th International Congress of Corneal Cross-Linking 15
  • 16. 28Y. M. OD (Post-Lasik Ectasia) Pre-ICR Post-ICR Post-PRK+ CXL 7th International Congress of Corneal Cross-Linking 16
  • 17. 38Y. M. OS Pre-ICR Post-ICR Post-PRK+ CXL 7th International Congress of Corneal Cross-Linking 17
  • 18. 38Y. M. OD Pre-ICR Post-ICR Post-PRK+ CXL 7th International Congress of Corneal Cross-Linking 18
  • 19. 43Y. M. OS Pre-ICR Post-ICR Post-PRK+ CXL 7th International Congress of Corneal Cross-Linking 19
  • 20. 26Y. M. OD Pre-ICR Post-ICR Post-PRK+ CXL 7th International Congress of Corneal Cross-Linking 20
  • 21. 21Y. M. OS Pre-ICR Post-ICR Post-PRK+ CXL 7th International Congress of Corneal Cross-Linking 21
  • 22. 16Y. M. OS Post-ICR Pre-ICR Post-PRK+ CXL 7th International Congress of Corneal Cross-Linking 22
  • 23. 25Y. M OD Pre-ICR Post-ICR Post-PRK+ CXL 7th International Congress of Corneal Cross-Linking 23
  • 24. Pre-ICR Post-ICR Post-PRK-CXL 7th International Congress of Corneal Cross-Linking
  • 25. Pre-ICR Post-ICR Post-PRK-CXL 7th International Congress of Corneal Cross-Linking
  • 26. Pre-ICR Post-ICR Post-PRK-CXL 7th International Congress of Corneal Cross-Linking
  • 27. Pre-ICR Post-ICR Post-PRK-CXL
  • 28. Pre-ICR Post-ICR Post-PRK-CXL 7th International Congress of Corneal Cross-Linking
  • 29. Pre-ICR Post-ICR Post-PRK-CXL
  • 30. Pre-ICR Post-ICR Post-PRK-CXL
  • 31. Pre-ICR Post-ICR Post-PRK-CXL
  • 32. Pre-ICR Post-ICR Post-PRK-CXL
  • 33. Difference between Difference between Difference between Factor Pre-ICR & Post-ICR Post-ICR & Pre-ICR & Post-PRK+CXL Post-PRK +CXL UNCVA 0.38 0.23 0.61 (0.1 - 0.35) ( 0 - 0.3) (0.1 - 0.65) BCVA 0.09 0.10 0.19 (-0.2 -0.2) (0 - 0.3) (-0.2 -0.5) Spherical -3.06D -1.81D -4.88D Equivalent (S.E.) (1.12 - 6.5) (-2.78 - 1) (-1.75 - 7.5) Corneal -1.88D -0.02D -1.90D Astigmatism (0.7 - 6.24) (0.07 - (-0.24)) (0.46 - 6.17) Max K 3.23D 3.01D 6.25D (1.96 - 5.73) (2.13-3.79) (5.75 - 7.86) Average K 2.33D 3.56D 5.88D (1.57 – 5.19) (3.47 – 5.58) (5.04 – 10.77) Coma 0.66 0.32 0.98 (0.4-0.64) (-0.2 - 1.0) (0.2-1.64) Ablation Depth 60um (27 – 125)
  • 34.  Based on our review, ICR followed later by PRK+CXL is an effective & safe approach in making a functional change in the life style of cases of moderate KC  We recommend to be done for the following group of patients ….. 7th International Congress of Corneal Cross-Linking 34
  • 35. 1. MAX K 55D or less 2. Sphere -6D 3. Coma 1.5-4.0 u 4. Post. Elevation >?? 5. Pachymetry 450 u or more 6. Clarity Clear cornea 7. Gain of lines 2 lines or more (expect to achieve in 2nd step) 7th International Congress of Corneal Cross-Linking 35
  • 36. Saudi Desert Mecca Riyadh Elite 36