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Figuresforpaper 3

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SHAPE Society

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Figuresforpaper 3

  1. 1. Does spatial heterogeneity of (experimental) plaques contain information
  2. 2. Introduction • Plaque rupture occurs predominantely upstream of plaques in carotid artery • Vulnerable plaque occurs at first 30 cm of coronary arteries
  3. 3. Hypothesis • This heterogeneity may help to identify us with regional mechanism independent of classical risk factors
  4. 4. Aim • Introduce a new 3D histology technique • Provide evidence for the mechanism that local accumulation of lipids activates inflammatory cells to produce plaque weakoning factors
  5. 5. oxLDL Macrophages MMPs SMC
  6. 6. 50403020100 x106 Distance from Renal Artery (mm) 0 1 2 3 PlaqueArea(µm2 ) Plaque Area Distance from Renal Artery (mm) 5 1 0 1 5 0 50403020100 Density(%) Macrophages 60 50403020100 40 20 Density(%) Distance from Renal Artery (mm) Lipids 0 60 50 40 30 20 10 0 50403 0 2 0 100 Density(%) Distance from Renal Artery (mm) Smooth Muscle Cells
  7. 7. 0 5 10 15 20 25 50403020100 Distance from Renal Artery (mm) VI-index Plaque area VI-index
  8. 8. A C D B
  9. 9. oxLDL distibutionMMP activity smcsmc mac mac MMP-activity Ox-LDL accumulation unknown unknown
  10. 10. A B

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