SHAPE Society

1. Optical Coherence Tomography
: Unstable Plaque Morphology
I.K. Jang, MD
Massachusetts General Hospital
Harvard Medical School
VP.ORG Symposium
November 16, 2002

2. OCT Charateristics
 Fibrous - Echodense, homogenous
 Lipid - Echolucent with diffuse border
 Calcific - Echolucent with sharp border

3. Plaque Morphology:
Stable vs Unstable
Coronary Syndromes

4. Stable Angina Pectoris

5. f
A B
f
i
m
a
2x
*
*
Fibrous Plaque

6. A
*
C
B
*
D
Calcified Plaque

7. A B
f
f
*
Lipid-rich Plaque

8. A B
2x
*
Lipid-rich Plaque

9. Post AMI

10. Post-AMI
L
L
T

11. Post-AMI Stent
A B

12. Post-AMI
Results
 High incidence of lipid-rich
plaque
 Frequent disruption of plaque
 High incidence of residual
thrombus
 Frequent prolapse post stenting

13. Acknowledgements
Massachusetts General Hospital
Cardiology Division
H. Yabushita, M. Takano, B. MacNeill, D. DeJoseph
Wellman Laboratories of Photomedicine
B.E. Bouma, M. Shishkov, C. Kauffman, N. Iftima, G.J. Tearney
Dept. of Pathology
S. Houser, H.T. Aretz
CIMIT
T. Brady, J. Rosen
Guidant Corporation
D. Kilpatrick, J. Ellis, R. Jones, T. Linnemeier