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Hyper-Accelerating Commercialization and
Economic Growth by
Catalyzing the Start-up Ecosystem
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
POWERING GROWTH:
Team Capability:
• 20 years + experience in commercializing inventions;
evaluated75K+ inventions
• Advisors: Serial Entrepreneurs, Industry, Foundations
• Core Team: ~20 people. 90% PhDs, MBAs
• 120+ high profile, strategy engagements:$21B profit
Unique Challenge-Accelerator given IP & Talent Access:
• Derisked IP: 21 agreements across NASA, NIH, NCI,
CDC, etc
• Talent: 85+ Serial Entrepreneurs, Industry, etc.
Evolution:
• Derisked IP: More Federal Labs
• Disrupting the Venture architecture norms
CAI’s Approach
Commercialization Strategy
Startups & Industry
Due Diligence – Selecting Investments
& Technologies
Select the Best Federally Funded Inventions
Maximize Commercial Potential
Operators & Management Talent
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
Center	
  for	
  Advancing	
  
Innovation—Overview	
  
New Model for Venture Philanthropy
with outsized returns
Spun out 33 Companies from NIH;
1200+ Jobs Created; 19
Agreements with NIH and NASA
Prestigious Awards & Recognition HHS,
NASA, White House, Wired, Nature,
Huffington Post, CBS etc.
Challenge	
  Accelerators
Since	
  2012
-­‐
500	
  
1,000	
  
1,500	
  
2,000	
  
2,500	
  
3,000	
  
3,500	
   2009
2011
2013
2015
2017
2019
2021
2023
2025
2027
2029
2031
RE	
  ($Billions,	
  PPP1)
CAGR	
  Forecast	
  of	
  GERDII	
  Expenditure	
  
(based	
  on	
  UNESCO	
  1996-­‐2009)
Brazil
Canada
China
India
Japan
Russia
S.	
  Korea
Singapore
US
EU
4
In	
  addition,	
  R&D	
  forecasts	
  show	
  China	
  will	
  surpass	
  the	
  US	
  by	
  2019
2019
Sources:	
  CAI	
  Analysis	
  Model,	
  UNESCO	
  Institute	
  for	
  Statistics
1PPP:	
  purchasing	
  power	
  parity	
  (PPP)	
  asks	
  how	
  much	
  money	
  would	
  be	
  needed	
  to	
  purchase	
  the	
  same	
  goods	
  and	
  services	
  in	
  two	
  
different	
  countries	
  
II	
  Gross	
  Expenditure	
  on	
  R&D
2009	
  RE	
  Top	
  5:
1. US
2. EU
3. Japan
4. China
5. S.	
  Korea
2031	
  RE	
  Top	
  5:
1. China
2. US
3. EU
4. Japan
5. S.	
  Korea
China
US
EU
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
Global	
  Expenditure	
  on	
  R&D	
  (GERD)
Global	
  forecasts	
  predict	
  similar	
  trends:	
  lost	
  leadership	
  position	
  in	
  2014
Sources:	
  CAI	
  Analysis	
  Model,	
  WIPO
CAGR	
  Forecast	
  Patents	
  Issued
(based	
  on	
  1996-­‐2009)
CAGR	
  Forecast	
  Patent	
  Applications
(based	
  on	
  1996-­‐2009)
0
200000
400000
600000
800000
1000000
1200000
1400000
1600000
2009 2016 2021 2026 2031
Patent	
  Applications
EU India Japan S.	
  Korea US
0
100000
200000
300000
400000
500000
600000
700000
800000
900000
1000000
2009 2016 2021 2026 2031
Patent	
  Grants
EU India Japan S.	
  Korea US
US
US
0
10
20
30
2009 2031
Millions	
  Patent	
  
Apps
0
10
20
30
2009 2031
Millions	
  Patent	
  
Grants
China	
  (surpassed	
  
the	
  US	
  in	
  2014)
China	
  (surpassed	
  
the	
  US	
  in	
  2014)
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
Global	
  PATENTS
Globally,	
  return	
  on	
  innovation	
  is	
  declining;	
  the	
  US	
  is	
  not	
  declining	
  as	
  fast!	
  
Sources:	
  CAI	
  Analysis	
  Model,	
  UNESCO	
  
Institute	
  for	
  Statistics,	
  World	
  Bank	
  GDP	
  
Estimates
0
10
20
30
40
50
60
70
80
90
2009
2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
GDP	
  /	
  RE
CAGR	
  Real	
  GDP	
  (Applied	
  to	
  Nominal)	
  Forecast	
  /	
  
CAGR	
  GERD	
  Forecast	
  
(based	
  on	
  1996-­‐2009	
  World	
  Bank,	
  UNESCO)
Brazil
Canada
China
India
Japan
Russia
S.	
  Korea
Singapore
US
EU
US China
Country
CAGR	
  
‘02-­‐’09
CAGR	
  
‘04-­‐’09
India 2.6% 6.5%
Russia 2.6% 9.4%
Canada 2.1% 6.2%
US 1.3% 0.04%
EU 1.0% 0.93%
Brazil -­‐0.9% 11.3%
Japan -­‐2.1% -­‐1.5%
S.	
  Korea -­‐2.8% -­‐4.0%
China -­‐2.9% 6.9%
Singapore -­‐4.3% 2.6%
CAI	
  Proprietary	
  and	
  	
  Confidential.	
  Do	
  not	
  distribute	
  outside	
  of	
  CAI	
  	
  without	
  written	
  permission
GERD	
  CAGR
Global	
  RETURN	
  on	
  Innovation
$0
$5,000
$10,000
$15,000
$20,000
$25,000
$30,000
$35,000
$40,000
2009
2012
2015
2018
2021
2024
2027
2030
GDP	
  (Billions) CAGR	
  Real	
  GDP	
  Forecast	
  Applied	
  to	
  
Nominal	
  GDP
(based	
  on	
  1996-­‐2009	
  World	
  Bank)
Singapore
United	
  States
Japan
South	
  Korea
Canada
Russia
Brazil
India
EU
China
GDP	
  Growth	
  Rate
US	
  =	
  2.32% China	
  =	
  9.25%
2024
Sources:	
  CAI	
  Analysis	
  Model,	
  
UNESCO	
  Institute	
  for	
  Statistics,	
  
World	
  Bank	
  GDP	
  Estimates
Innovation	
  Arms	
  Race
Licensed
Move to translational research
More funding in lab; science continues
No funding in lab to continue
Withdrawn/terminated license
Terminated by inventor
Federally	
  
Funded	
  
Research
Invention	
  
Disclosed	
  and	
  
Potentially	
  
Patented
Product
Translational	
  Research,
<0.1%
Inability	
  to	
  Find	
  
and	
  Fund	
  
Promising	
  
Inventions
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
Problem:	
  Identifying	
  the	
  Best	
  Inventions
and	
  Furthering	
  R&D
915
122
2619
132
458
804
1150
31%
27%
55%
12%
96%
42%
79%
0%
20%
40%
60%
80%
100%
120%
0
500
1000
1500
2000
2500
3000
Federal2Labs Top2Hospitals Top2Med2Schools Top2Universities Bottom2 Hospitals Bottom2 Med2
Schools
Bottom2
Universities
%"of"Disclosures"Removed"from"Shelf
Additional"Disclosures"Removed"from"Shelf
Yearly"Additional"Disclosures"Removed"from"Shelf"by"Segment"–
Best=in=Class"Performance
(%"Removed"from"Shelf)
Segment Federal2Labs Top2Hospitals Top2Med2Schools Top2Universities Bottom2 Hospitals
Bottom2 Med2
Schools
Bottom2
Universities
#2of2
Institutions
8 5 35 3 16 41 45
114/Federal2
Lab
12K742
Additional2
Inventions
7K252
Additional2
Inventions
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
150,000	
  inventions	
  from	
  the	
  top	
  145	
  institutions
Potential
Current
State
Key$Insight
US.universities.can.still.improve.by.
at.least.25%,.while.federal.labs.
have.>80%.potential.growth.in.
every.stage.of.commercialization
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Licenses.&.Options.+.
Startups
Invention.Disclosures.
Patents.Issued.
Patent.Applications.
License.Income.
Current$Universities$Potential
vs.$Average
(AUTM$2002<2009)
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Licenses.&.
Options.+.…
Invention.
Disclosures.
Patents.Issued.
Patent.
Applications.
License.Income.
Current$Federal$Labs$Potential
vs.$Average
(NSF/NIST$2002<2009)
Sources:.The.Center.for.Advancing.Innovation.Analysis.Model,.
NIST,.NSF,.AUTM.Survey.2002V2009
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
Average
State
Average	
  Performance	
  Opportunity
Potential
Current
State
Key$Insight
US.universities.and.federal.labs.
have.>500%.potential.growth.in.at.
every.stage.of.commercialization
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Licenses.&.Options.+.
Startups
Invention.Disclosures.
Patents.Issued.
Patent.Applications.
License.Income.
Current$Universities$vs.$BIC$
Potential (AUTM$2002=2009)
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Licenses.&.Options.+.
Startups
Invention.Disclosures.
Patents.Issued.
Patent.Applications.
License.Income.
Current$Federal$Labs$vs.$BIC
(NSF/NIST$2002=2009)
Sources:.CAI.Analysis.Model,.NIST,.NSF,.AUTM.Survey.2002U
2009
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
Best-­‐‑in-­‐‑Class	
  Performance	
  Opportunity
Dimension Current	
  State	
  (2009) Opportunity %	
  Difference
GDP $49,068,748,297 $864,230,818,581 1661%
#	
  Licenses 3922 43885 1019%
Current	
  Universities	
  Potential
Dimension Current	
  State	
  (2009) Opportunity %	
  Difference
GDP $4,056,551,354 $623,614,223,359 15273%
#	
  Licenses 1462 31667 2066%
Current	
  Federal	
  Laboratories	
  Potential
Dimension Current	
  State	
  (2009) Opportunity %	
  Difference
GDP $53,125,299,651 $1,487,845,041,940 2701%
#Licenses 5384 75551 1303%
Cumulative	
  Potential
3-­‐6%	
  Inventions	
  
x	
  
80-­‐90%	
  failure	
  rate
$500	
  billion	
  to	
  $1.5	
  trillion
The	
  $1.5	
  Trillion	
  Opportunity
What is it? A business plan and start-up
challenge featuring inventions conceived
and developed by scientists at NASA
Challenge Goal: Drive economic growth and create/ amplify
entrepreneurial platforms by commercializing NASA inventions
Challenge End Point: New startups launched with seed funding
Space	
  Race	
  Overview
Step 1:
Create PIA
Agreement
Step 2:
Received Invention
Database Info
Inventions	
  
~50,000
Step 3:
Perform Due Diligence
on Portfolio
…
Market
Attractiveness
Tech
Quality
Operational
Feasibility
Other Categories
§ Patent life
§ Capitalefficiency
§ Progress vs. promise
Step 4:
Recommend
Disposition
Commercialize
Reward
Kill
Restructure
Step 5:
Determine
Commercialization
Path
Startup
License
Large Co
License
CRADA
Other
Business
Model
Phase I: Due Diligence
Phase 2: Startup Challenge
Select Inventions Crowdsource Teams
Evaluate Elevator
Speeches
Evaluate Business
Plans
Launch Startups
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
The	
  Model
Phase	
  
0:	
  
Enter	
  
Challe
nge
Jan.	
  
19th
2015–
May	
  
1st	
  
2016
• Teams	
  
submit	
  
propose
d	
  team	
  
and	
  
accept	
  
CDA.	
  	
  
Rolling	
  
entry	
  
into	
  
challeng
e
• Jan.	
  
19th:	
  
Open	
  
challeng
e	
  for	
  
entries,	
  
rolling	
  
acceptan
1:	
  
Elevat
or	
  
Speec
h
May	
  
2nd
2016	
  –
Jun.	
  
15th
2016
• Teams	
  
develop	
  
a	
  2	
  
minute	
  
elevator	
  
speech	
  
video	
  
and	
  also	
  
a	
  350	
  
word	
  
executiv
e	
  
summar
y
• Jun.	
  5th:	
  
Due	
  date	
  
for	
  
elevator	
  
speech	
  
and	
  
executiv
e	
  
Phase	
  
2:	
  
Busine
ss	
  Plan
Jun.	
  
16th
2016	
  –
Sep.	
  
9th
2016
• Teams	
  
develop	
  
a	
  10	
  
page	
  
business	
  
plan	
  
accompa
nied	
  by	
  a	
  
10-­‐20	
  
minute	
  
live	
  pitch
• Aug.	
  
21st:	
  Due	
  
date	
  for	
  
business	
  
plans
• Aug.	
  
22nd –
Aug.	
  
26th:	
  
Phase	
  
3:	
  
Start-­‐
up
Sept.	
  
9th
2016	
  –
TBD
• Teams	
  
launch	
  
their	
  
startup;	
  
raise	
  
capital	
  
and	
  
apply	
  for	
  
a	
  license
• Bi-­‐
weekly	
  
mileston
es	
  for	
  
teams	
  –
schedule	
  
to	
  be	
  
outlined
• TBD:	
  
Announc
Space	
  Race	
  Challenge	
  Timeline
Select SPACE RACE
Challenge Topic and
Engage Stakeholders
Planning
Startup teams paired with
world-class, seasoned exec
level industry experts
Mentorship
Invention
Selection
Tailored
Training
Curriculum
Business Plan
and Live Pitch
Multi-
Disciplinary
Teams Enter
2 minute video with
executive summary
Elevator Speech
Winners and
Finalists
Selected
Identify 5-10 commercially
viableinventions
Form Team and
Select Invention
Letter of Intent - robust teams
enter with world class mentors
Elevator speech - 5 teams per
invention evaluated& down-
selected
Business Plan - Teams pitch to
world class panel of judges
Winning teams become founders
of startup, negotiate license &
raise seed funding
12 Month Intensive & Disciplined Accelerator Training
500-1000 people
combine to form multi-
disciplinaryteams
Partnership
And Licensing
Agreements
LAUNCH
STARTUPS
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
Space	
  Race	
  Overview	
  and	
  Accelerator	
  Training
NASA
Inventions
TeamsFormedwith
inventions
Start-ups
Formed
Potential
Exits
Team 1 Team 1 Team 1 Team 1 Team 1 Team 1 Team 1 Team 1 Team 1 Team 1
Team 2 Team 2 Team 2 Team 2 Team 2 Team 2 Team 2 Team 2 Team 2 Team 2
Team 3 Team 3 Team 3
Team 4 Team 10 Team 12 Team 4 Team 10 Team 8 Team 15 Team 10 Team 9
Invention#1 Invention#2 Invention#3 Invention#4 Invention#5 Invention#6 Invention#7 Invention#8 Invention#9 Invention#10
Startup
#1
Startup
#2
Startup
#3
Startup
#4.A
Startup
#5
Startup
#6
Startup
#7
Startup
#8.A
Startup
#9
Startup
#10
Startup #
4.B
Startup
#8.B
Year 1 Startups Year 2 Startups
Exit
#4.B
Exit
#7
Confidential & Proprietary – Center for
Advancing Innovation and Gazelle Futures LLC
- Do Not Distribute
Space	
  Race—Crowdsourcing	
  Top	
  Global	
  Talent
Overview:
Self-monitoring
electronics that can
detect and diagnose
wirefaults, determine
fault location,
A Device For Wire Fault
Detection and Rerouting
Electrical and Electronics
and autonomously transfer electrical power or
data connectivity to an alternate wire path
Inventions –
Electrical and Aeronautics
Overview: A
ceramic composite
(CMC) acoustic liner
for aircraft engines that
offers increased noise
reduction with a lighter,
more compact, and
heat resistant design
Light Weight Acoustic
Liner to Reduce Noise in
Aircraft Engines
Aeronautics
Overview: A Lightweight
UAV sensing and control
system able to be fitted for
drones and nano-drones
reaching one pound or less
and/or <6-inch wingspans,
Light Weight UAV
Sensing and Control
System
allowing for long flight segments due to its power-
saving capabilities
Inventions –
Robotics
Overview:
Rugged,
lightweight,
small
autonomous
robot excavator
RASSOR Robotic
Excavator
used in inaccessible sites such as
high-risk mining, search and rescue
as well as disaster response
applications
Inventions –
Optics
Overview:A 3D
imaging laser system
that uses a simple lens
system to
simultaneously
generate a
High-resolution, real-time
three-dimensional
imaging
one-dimensional or two-dimensional array of
optical (light) spots to illuminate an object,
surface or image to generate a topographic
profile.
Overview:
Cost effective method for
high precision polishing to
shape optical surfaces by
employing an
Electrochemically
Enhanced Mechanical
Polishing (EEMP)
electrochemical and mechanical shaping /
polishing method
Inventions –
Energy
Overview:
AirborneWind Energy
(AWE) vehicles use
the wind to generate
power at higher
altitudes;
Kite-like Wind Power
Generation Control
System
this invention maximizes and optimizes AWE
power generation
Overview: A solid
oxide fuel cell capable of
power densities 5X of a
normal power cell due to
a unique fabrication
High-Power Density
Solid Oxide Fuel Cell
and Fabrication Process
process utilizing a freeze-tape casting method
Inventions –
Materials and Coatings
Overview:
Novel use of laser
surface pattering and
chemical film coatings
to create surfaces
resistant
Surface Particle
Contamination Mitigation
Methods
to water, dust, organic growth, and other
surface contaminants
Overview:
Liquid and micro-particle
powder coating applied
on the surface of
reinforced concrete for
Liquid Coating for
Corrosion Prevention in
Rebar
corrosion prevention and structural integrity
in steel rebars
Unique	
  Inventions,	
  Incredible	
  Deal	
  Flow	
  
Example NASA Robotics Invention
Overview:
Rugged,
lightweight, small,
autonomous robot
excavator used in
sites such as
RASSOR Robotic Excavator
high-risk or inaccessible mining, search and
rescue, as well as disaster response
applications
Only invention to exploit $25 quadrillion
extraplanetary mining industry; $200B to
$1T of value in just one asteroid
TRL 9, space-flight tested, $35.8M taxpayer
dollars invested in R&D
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
11 more late-stage inventions:
• Focused on space technologies, precision
medicine, clean energy, and others
• Selected from NASA portfolio of 24K+
inventions: 100+ commercially viablespace
inventions; 300+ precision medicine
Expanding portfolio: patents and inventions from
DoD, DoE, DARPA, Navy and other government-
funded agencies
Low deal flow: currently only ~90 VC-backed space
companies from 2000-2015
Opportunity: develop world-changing technologies,
create new industries and ecosystems, drive
outsized growth and returns
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
Startup Challenge Evolution to Fund
Early investors end up <20%
minority interest, often without
enough power to kill the
“walkingdead” & redeploy
Investors attempt to short
list the best out of the
noise through quality of
team, traction and solid
plan
Investors often deal with
unsophisticated founders
who don’t understand
governance or valuation
Early Stage investors often
receive 100’s if not 1000’s
of pitch decks, emails or via
fast pitch events for dealfow
Invest
(1-5)
Term Sheet
(5-10)
Diligence
(10-25)
Pitch
(100’s)
Diligence
(1000’s)
Invest
(2-5)
Source
BPs &
Teams/Tech
(5-10)
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
Solving	
  Early	
  Stage	
  Investing	
  Problems
Quality Strategic Deal Flow
Struggles to find worthy opportunities
matched to strategic needs
Capital Efficiency
Most IP is capital & time intensive. Cost
reduction levers are key, e.g., startup nimbleness
and regional advantages
Skilled Startup Teams
Seasoned entrepreneurs seeded in teams
prevent rooky mistakes
Accelerated Results
Teams require funding and go around the
US to raise it for 6-12months
Commercialization Risks
Inventions require de-risking –
lead to high failure rates
Favorable Terms
Licensing agreements often have onerous
deal terms and are quick to negotiate
R&D$
Productivity
Size$of$R&D$Organization
Large&
Pharma&Co’s
Optimal&
Size
89%
92%
65%
21%
52%
34% VALUE&OPPORTUNITY&ANALYSIS
YOUR&PRODUCT
adventure
independance
security
sensuality
confidence
power
comfort
safety
ease3of3use
visual
auditory
tactile
olfactory
taste
point3in3time
sense3of3place
personality
social
environmental
reliable
enabling
craftmanship
durability
LOW MED HIGH
Emotion
Ergonomics
Aesthetics
Identity
Impact
Core4Tech.
Quality
Profit4Impact
Brand4Impact
Extendable
COMPETITION&(OR&NEXT&PRODUCT)
adventure
independance
security
sensualtiy
confidence
power
comfort
safety
ease3of3use
visual
auditory
tactile
olfactory
taste
point3in3time
sense3of3place
personality
social
environmental
reliable
enabling
craftmanship
durability
LOW MED HIGH
Emotion
Ergonomics
Aesthetics
Identity
Impact
Core4Tech.
Quality
Profit4Impact
Brand4Impact
Extendable
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
Gazelle	
  Solves	
  Pipeline	
  Challenges
An early stage venture capital fund that
leverages exclusive, low-cost access to a large
portfolio of risk mitigated inventions combined
with a proven and award winning “Startup
Challenge Accelerator” to rapidly launch new
capital efficient companies and grow jobs.
Gazelle Futures Mission
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
Financial Impact
$90MEndowment
20Companies
56%+Fund IRR
Investing + “venture philanthropy” of
LP’s 50% split carrycreates a sustainable
source of future funding
Proven, award winning accelerator
matches inventions to region’s strengths
& significantly increases new startups
Securing the majority of equity at the
early stage captures all value creation,
resulting in strong for all investors
Even with highly conservative assumption
of 90% failure failure rate, startups jobs
generate a large commerce impactin area
$600M
Social Impact
$180MInvestor Returns
Limited Partners that invest capital
are positioned to realize strong exit
return multiples over the 10 yr life
GDP Impact
82%Employment
Challenge graduates have attractive
entrepreneurial skills that lead to high
job placement success in market
2500Trained
Over 500+ people per year x 5 years
receive advanced STEM training during
the 12 month accelerator process
18KTotal Jobs
Growing Life Science oriented startups
creates a large multiplier effect, leading to
job growth throughout the local ecosystem
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
Measurable	
  Impact	
  with	
  $20MM	
  Fund
Target	
  Case
Gazelle Futures Fund Overview
9 yr | 4 yr Investing
Fund Horizon
Match to Region
Strengths
Market Focus
Seed to Series A
Stage Focus
$20MM Segments
($100MM Total)
Total Fund
Under-valued Regions
Geographic Focus
Performance Based
GP Carry Interest
5x + Exit Targets
Outsize Returns
$200K - $1.2MM
Investment Size
10-20 Seed | Series A
Investments
Substantial 100%
Equity Positions
Gazelle Futures| 9508 Burning Tree Road; Bethesda, MD 20817 USA
rht@gazellefutures.com | (202) 438-2208 | www.gazellefutures.com
Fund Mission
De-risked, Capital Efficient
§ Builds on successful startup model
§ Breast Cancer Startup Challenge, Neuro
Startup Challenge
§ Kaufmann Foundation proprietary
research
§ STEM and entrepreneurship education
Differentiation
Unique Deal/Team Access
§ Unprecedented no/low-cost
licensing access
§ De-risked portfolio of 24,000 NIH
& NASA inventions
§ Crowd source global talent
Investment Strategy
“Lead Seed”-Founder Friendly
§ Up to $1MM+ seed investments
§ Founder friendly support from
industry experts
§ lowest cost/% ownership and
maintaining substantial positions
through future dilutive rounds
Social Impact Financials
100% Performance Based
§ Performance based IRR goals
§ Creation of regional endowment
§ 2.5% mgmt fee for Challenge
Accelerator.
Confidential & Proprietary | DO NOT DISTRIBUTE
Experienced Investment Team
Rosemarie H. Truman
Managing Partner
- CEO, Center for Advancing Innovation
- Launched 33 Award Winning NIH Startups
- 22 Yrs & $210B+ F500 Growth Strategy
- IBM, Goldman, JP Morgan, E&Y,Oracle
Nick Donafrio
Board Chairman
- IBM VP of Global Innovation and
Technology for 35 years (IBM Watson)
- Industry and thought leader
- MITRE, Liberty Mutual, Wigix, others
BENEFITS
Disruptive	
  Investors
§ Outsized	
  returns	
  and	
  IRRs
§ Diverse	
  invention	
  
portfolio:	
  energy,	
  
personalized	
  medicine,	
  
adv.	
  manufacturing
§ Performance	
  driven	
  fund
§ Proven,	
  efficient,	
  data	
  
driven,	
  award-­‐winning,	
  
investment	
  model
§ Impact	
  investing	
  with	
  
multiplier	
  effect	
  
§ Network	
  expansion	
  –
AUTM,	
  BIO,	
  White	
  House,	
  
etc.
Government	
  and
Tech	
  Transfer:
§ Multiplier	
  effect	
  in	
  
impacting	
  public	
  health,	
  
energy,	
  medicine,	
  other	
  
sectors
§ Supports	
  the	
  Presidential	
  
Memorandum	
  and	
  
Startup	
  America
§ New	
  paradigm	
  of	
  
commercializing	
  
inventions
§ Expanded	
  private	
  
funding	
  for	
  R&D
§ New	
  platform	
  to	
  train	
  
the	
  next	
  generation	
  of	
  
scientists
§ Support	
  STEM	
  education
Powering	
  Growth:
§ Train	
  1000s new	
  STEM	
  entrepreneurs
§ Create	
  100s	
  startups
§ Create	
  millions	
  of	
  new	
  jobs
§ Support	
  regional	
  sustainability
§ Contribute	
  to	
  GDP	
  through	
  new	
  products
CAI	
  and	
  Gazelle	
  Futures:
§ Drive	
  and	
  accelerate	
  high	
  growth	
  business
§ Increase	
  the	
  volume	
  of	
  commercialization
§ Accelerate	
  ground	
  breaking	
  innovations
Key	
  Takeaways	
  for	
  Stakeholders
Rosemarie Truman: (202) 438-2208
twitter.com/centerinnovate
www.thecenterforadvancinginnovation.org
https://www.linkedin.com/company/the-center-for-advancing-innovation-inc-
?trk=biz-companies-cym
Contact
9508 Burning Tree Road, Bethesda, MD 20817
The Center for
Advancing Innovation, INC
Gazelle Futures, INC
Rosemarie H. Truman | Founder and CEO
Sourav Sinha | Entrepreneur in Residence
rt@thecenterforadvancinginnovation.org
Key Takeaways
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
§ YOU can do this too! We’ve built a nice platform AND have lessons learned
§ Join the SPACE RACE; build a team; be a judge; advise the challenge; mentor a team
§ GAZELLE is seeking strategic partnerships & advisors; please connect with us if interested
THANK YOU
ROSEMARIE TRUMAN, FOUNDER AND CEO
SOURAV SINHA, ENTREPRENEUR IN RESIDENCE
THE CENTER FOR ADVANCING INNOVATION
RT@THECENTERFORADVANCINGINNOVATION.ORG
TEXT: 202 438 2208
Healthy Cell Cancer Cell
No Effect Azonafide
Kills Cell
§ Winner of Breast Cancer Startup Challenge by the National Cancer
Institute (NCI)
§ Awarded grants from Avon Foundation for Women, NASA/Center
for the Advancement of Science in Space (CASIS), and the Horizon
2020 Program (UK)
§ Winner of MassChallenge & MassBio 2014 Startup Accelerators
§ Winner of the Rice Business Plan Competition
§ Raised seed financing, currently raising a bridge round
§ Partnered with 14 pharma partners all over the world
§ Partnered with 6 academic labs all over the world
§ Offices in Boston and London
§ Closed Startup Exclusive Option License Agreement with the NCI
§ Showcases: TEDMED, World ADC Summit, Engage Forum Tokyo,
Protein & Antibody Engineering Summit (Shanghai & Boston ’15)
Team Progress
Startup Challenge Evolution to Fund
CAI$performs
due$diligence
on$exclusive$access$
invention$portfolio
CAI$runs$
challenge/accelerator,$
crowd;sourcing$startup$
teams.$Teams$apply$
for$SBIR$funds
CAI$selects$winning$
business$plans$and$
teamsC$CAI$facilitates$
licensing$agreement
Gazelle$exclusive$$
deal$with$CAI$to$
perform$due$
diligence
Gazelle$creates$
company$vehicle$for$
inventions$– and$
owns$100%
Gazelle$funds$
startup$leadership$
and$provides$first$
tranche$fundingC$
owns$55%$equity
Space&Race
Gazelle$performs$
ongoing$governance$
and$has$strict$go/no;
go$milestones
Gazelle$puts$in$
Series$A$fundingC$
funding$is$matched.$
Valuations$double
Liquidity$Event$
Gazelle$pays$out$
to$LPs
Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
Who Can Join the SPACE RACE?
Recruiting Multi-Disciplinary Teams
Team Design:
Mandatory Requirements
Challenge	
  TEAM
Business
Legal
Invention Specific	
  
Technical	
  
Seasoned	
  
Entrepreneur
Typical Participation
Students:
• Graduate and undergraduate students
• Post-docs as well as those in residency
Others - match skill sets of mentors to invention and team:
• Business Development Leaders from Large Companies
• Key Opinion Leaders
• FDA/Regulatory
• Venture Capitalists
• Clinical Research Outsourcer (CRO)
• Over	
  18	
  years	
  old*
• At	
  least	
  three	
  students	
  on	
  the	
  team
*and youngerwith parent’spermission as long as the rest of the team meets requirements
Confidential & Proprietary to The Center for Advancing Innovation. Do Not Distribute

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FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

  • 1. Hyper-Accelerating Commercialization and Economic Growth by Catalyzing the Start-up Ecosystem Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission POWERING GROWTH:
  • 2. Team Capability: • 20 years + experience in commercializing inventions; evaluated75K+ inventions • Advisors: Serial Entrepreneurs, Industry, Foundations • Core Team: ~20 people. 90% PhDs, MBAs • 120+ high profile, strategy engagements:$21B profit Unique Challenge-Accelerator given IP & Talent Access: • Derisked IP: 21 agreements across NASA, NIH, NCI, CDC, etc • Talent: 85+ Serial Entrepreneurs, Industry, etc. Evolution: • Derisked IP: More Federal Labs • Disrupting the Venture architecture norms CAI’s Approach Commercialization Strategy Startups & Industry Due Diligence – Selecting Investments & Technologies Select the Best Federally Funded Inventions Maximize Commercial Potential Operators & Management Talent Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission Center  for  Advancing   Innovation—Overview  
  • 3. New Model for Venture Philanthropy with outsized returns Spun out 33 Companies from NIH; 1200+ Jobs Created; 19 Agreements with NIH and NASA Prestigious Awards & Recognition HHS, NASA, White House, Wired, Nature, Huffington Post, CBS etc. Challenge  Accelerators Since  2012
  • 4. -­‐ 500   1,000   1,500   2,000   2,500   3,000   3,500   2009 2011 2013 2015 2017 2019 2021 2023 2025 2027 2029 2031 RE  ($Billions,  PPP1) CAGR  Forecast  of  GERDII  Expenditure   (based  on  UNESCO  1996-­‐2009) Brazil Canada China India Japan Russia S.  Korea Singapore US EU 4 In  addition,  R&D  forecasts  show  China  will  surpass  the  US  by  2019 2019 Sources:  CAI  Analysis  Model,  UNESCO  Institute  for  Statistics 1PPP:  purchasing  power  parity  (PPP)  asks  how  much  money  would  be  needed  to  purchase  the  same  goods  and  services  in  two   different  countries   II  Gross  Expenditure  on  R&D 2009  RE  Top  5: 1. US 2. EU 3. Japan 4. China 5. S.  Korea 2031  RE  Top  5: 1. China 2. US 3. EU 4. Japan 5. S.  Korea China US EU Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission Global  Expenditure  on  R&D  (GERD)
  • 5. Global  forecasts  predict  similar  trends:  lost  leadership  position  in  2014 Sources:  CAI  Analysis  Model,  WIPO CAGR  Forecast  Patents  Issued (based  on  1996-­‐2009) CAGR  Forecast  Patent  Applications (based  on  1996-­‐2009) 0 200000 400000 600000 800000 1000000 1200000 1400000 1600000 2009 2016 2021 2026 2031 Patent  Applications EU India Japan S.  Korea US 0 100000 200000 300000 400000 500000 600000 700000 800000 900000 1000000 2009 2016 2021 2026 2031 Patent  Grants EU India Japan S.  Korea US US US 0 10 20 30 2009 2031 Millions  Patent   Apps 0 10 20 30 2009 2031 Millions  Patent   Grants China  (surpassed   the  US  in  2014) China  (surpassed   the  US  in  2014) Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission Global  PATENTS
  • 6. Globally,  return  on  innovation  is  declining;  the  US  is  not  declining  as  fast!   Sources:  CAI  Analysis  Model,  UNESCO   Institute  for  Statistics,  World  Bank  GDP   Estimates 0 10 20 30 40 50 60 70 80 90 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028 2029 2030 2031 GDP  /  RE CAGR  Real  GDP  (Applied  to  Nominal)  Forecast  /   CAGR  GERD  Forecast   (based  on  1996-­‐2009  World  Bank,  UNESCO) Brazil Canada China India Japan Russia S.  Korea Singapore US EU US China Country CAGR   ‘02-­‐’09 CAGR   ‘04-­‐’09 India 2.6% 6.5% Russia 2.6% 9.4% Canada 2.1% 6.2% US 1.3% 0.04% EU 1.0% 0.93% Brazil -­‐0.9% 11.3% Japan -­‐2.1% -­‐1.5% S.  Korea -­‐2.8% -­‐4.0% China -­‐2.9% 6.9% Singapore -­‐4.3% 2.6% CAI  Proprietary  and    Confidential.  Do  not  distribute  outside  of  CAI    without  written  permission GERD  CAGR Global  RETURN  on  Innovation
  • 7. $0 $5,000 $10,000 $15,000 $20,000 $25,000 $30,000 $35,000 $40,000 2009 2012 2015 2018 2021 2024 2027 2030 GDP  (Billions) CAGR  Real  GDP  Forecast  Applied  to   Nominal  GDP (based  on  1996-­‐2009  World  Bank) Singapore United  States Japan South  Korea Canada Russia Brazil India EU China GDP  Growth  Rate US  =  2.32% China  =  9.25% 2024 Sources:  CAI  Analysis  Model,   UNESCO  Institute  for  Statistics,   World  Bank  GDP  Estimates Innovation  Arms  Race
  • 8. Licensed Move to translational research More funding in lab; science continues No funding in lab to continue Withdrawn/terminated license Terminated by inventor Federally   Funded   Research Invention   Disclosed  and   Potentially   Patented Product Translational  Research, <0.1% Inability  to  Find   and  Fund   Promising   Inventions Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission Problem:  Identifying  the  Best  Inventions and  Furthering  R&D
  • 9. 915 122 2619 132 458 804 1150 31% 27% 55% 12% 96% 42% 79% 0% 20% 40% 60% 80% 100% 120% 0 500 1000 1500 2000 2500 3000 Federal2Labs Top2Hospitals Top2Med2Schools Top2Universities Bottom2 Hospitals Bottom2 Med2 Schools Bottom2 Universities %"of"Disclosures"Removed"from"Shelf Additional"Disclosures"Removed"from"Shelf Yearly"Additional"Disclosures"Removed"from"Shelf"by"Segment"– Best=in=Class"Performance (%"Removed"from"Shelf) Segment Federal2Labs Top2Hospitals Top2Med2Schools Top2Universities Bottom2 Hospitals Bottom2 Med2 Schools Bottom2 Universities #2of2 Institutions 8 5 35 3 16 41 45 114/Federal2 Lab 12K742 Additional2 Inventions 7K252 Additional2 Inventions Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission 150,000  inventions  from  the  top  145  institutions
  • 10. Potential Current State Key$Insight US.universities.can.still.improve.by. at.least.25%,.while.federal.labs. have.>80%.potential.growth.in. every.stage.of.commercialization 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% Licenses.&.Options.+. Startups Invention.Disclosures. Patents.Issued. Patent.Applications. License.Income. Current$Universities$Potential vs.$Average (AUTM$2002<2009) 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% Licenses.&. Options.+.… Invention. Disclosures. Patents.Issued. Patent. Applications. License.Income. Current$Federal$Labs$Potential vs.$Average (NSF/NIST$2002<2009) Sources:.The.Center.for.Advancing.Innovation.Analysis.Model,. NIST,.NSF,.AUTM.Survey.2002V2009 Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission Average State Average  Performance  Opportunity
  • 11. Potential Current State Key$Insight US.universities.and.federal.labs. have.>500%.potential.growth.in.at. every.stage.of.commercialization 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% Licenses.&.Options.+. Startups Invention.Disclosures. Patents.Issued. Patent.Applications. License.Income. Current$Universities$vs.$BIC$ Potential (AUTM$2002=2009) 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% Licenses.&.Options.+. Startups Invention.Disclosures. Patents.Issued. Patent.Applications. License.Income. Current$Federal$Labs$vs.$BIC (NSF/NIST$2002=2009) Sources:.CAI.Analysis.Model,.NIST,.NSF,.AUTM.Survey.2002U 2009 Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission Best-­‐‑in-­‐‑Class  Performance  Opportunity
  • 12. Dimension Current  State  (2009) Opportunity %  Difference GDP $49,068,748,297 $864,230,818,581 1661% #  Licenses 3922 43885 1019% Current  Universities  Potential Dimension Current  State  (2009) Opportunity %  Difference GDP $4,056,551,354 $623,614,223,359 15273% #  Licenses 1462 31667 2066% Current  Federal  Laboratories  Potential Dimension Current  State  (2009) Opportunity %  Difference GDP $53,125,299,651 $1,487,845,041,940 2701% #Licenses 5384 75551 1303% Cumulative  Potential 3-­‐6%  Inventions   x   80-­‐90%  failure  rate $500  billion  to  $1.5  trillion The  $1.5  Trillion  Opportunity
  • 13. What is it? A business plan and start-up challenge featuring inventions conceived and developed by scientists at NASA Challenge Goal: Drive economic growth and create/ amplify entrepreneurial platforms by commercializing NASA inventions Challenge End Point: New startups launched with seed funding Space  Race  Overview
  • 14. Step 1: Create PIA Agreement Step 2: Received Invention Database Info Inventions   ~50,000 Step 3: Perform Due Diligence on Portfolio … Market Attractiveness Tech Quality Operational Feasibility Other Categories § Patent life § Capitalefficiency § Progress vs. promise Step 4: Recommend Disposition Commercialize Reward Kill Restructure Step 5: Determine Commercialization Path Startup License Large Co License CRADA Other Business Model Phase I: Due Diligence Phase 2: Startup Challenge Select Inventions Crowdsource Teams Evaluate Elevator Speeches Evaluate Business Plans Launch Startups Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission The  Model
  • 15. Phase   0:   Enter   Challe nge Jan.   19th 2015– May   1st   2016 • Teams   submit   propose d  team   and   accept   CDA.     Rolling   entry   into   challeng e • Jan.   19th:   Open   challeng e  for   entries,   rolling   acceptan 1:   Elevat or   Speec h May   2nd 2016  – Jun.   15th 2016 • Teams   develop   a  2   minute   elevator   speech   video   and  also   a  350   word   executiv e   summar y • Jun.  5th:   Due  date   for   elevator   speech   and   executiv e   Phase   2:   Busine ss  Plan Jun.   16th 2016  – Sep.   9th 2016 • Teams   develop   a  10   page   business   plan   accompa nied  by  a   10-­‐20   minute   live  pitch • Aug.   21st:  Due   date  for   business   plans • Aug.   22nd – Aug.   26th:   Phase   3:   Start-­‐ up Sept.   9th 2016  – TBD • Teams   launch   their   startup;   raise   capital   and   apply  for   a  license • Bi-­‐ weekly   mileston es  for   teams  – schedule   to  be   outlined • TBD:   Announc Space  Race  Challenge  Timeline
  • 16. Select SPACE RACE Challenge Topic and Engage Stakeholders Planning Startup teams paired with world-class, seasoned exec level industry experts Mentorship Invention Selection Tailored Training Curriculum Business Plan and Live Pitch Multi- Disciplinary Teams Enter 2 minute video with executive summary Elevator Speech Winners and Finalists Selected Identify 5-10 commercially viableinventions Form Team and Select Invention Letter of Intent - robust teams enter with world class mentors Elevator speech - 5 teams per invention evaluated& down- selected Business Plan - Teams pitch to world class panel of judges Winning teams become founders of startup, negotiate license & raise seed funding 12 Month Intensive & Disciplined Accelerator Training 500-1000 people combine to form multi- disciplinaryteams Partnership And Licensing Agreements LAUNCH STARTUPS Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission Space  Race  Overview  and  Accelerator  Training
  • 17. NASA Inventions TeamsFormedwith inventions Start-ups Formed Potential Exits Team 1 Team 1 Team 1 Team 1 Team 1 Team 1 Team 1 Team 1 Team 1 Team 1 Team 2 Team 2 Team 2 Team 2 Team 2 Team 2 Team 2 Team 2 Team 2 Team 2 Team 3 Team 3 Team 3 Team 4 Team 10 Team 12 Team 4 Team 10 Team 8 Team 15 Team 10 Team 9 Invention#1 Invention#2 Invention#3 Invention#4 Invention#5 Invention#6 Invention#7 Invention#8 Invention#9 Invention#10 Startup #1 Startup #2 Startup #3 Startup #4.A Startup #5 Startup #6 Startup #7 Startup #8.A Startup #9 Startup #10 Startup # 4.B Startup #8.B Year 1 Startups Year 2 Startups Exit #4.B Exit #7 Confidential & Proprietary – Center for Advancing Innovation and Gazelle Futures LLC - Do Not Distribute Space  Race—Crowdsourcing  Top  Global  Talent
  • 18. Overview: Self-monitoring electronics that can detect and diagnose wirefaults, determine fault location, A Device For Wire Fault Detection and Rerouting Electrical and Electronics and autonomously transfer electrical power or data connectivity to an alternate wire path Inventions – Electrical and Aeronautics Overview: A ceramic composite (CMC) acoustic liner for aircraft engines that offers increased noise reduction with a lighter, more compact, and heat resistant design Light Weight Acoustic Liner to Reduce Noise in Aircraft Engines Aeronautics
  • 19. Overview: A Lightweight UAV sensing and control system able to be fitted for drones and nano-drones reaching one pound or less and/or <6-inch wingspans, Light Weight UAV Sensing and Control System allowing for long flight segments due to its power- saving capabilities Inventions – Robotics Overview: Rugged, lightweight, small autonomous robot excavator RASSOR Robotic Excavator used in inaccessible sites such as high-risk mining, search and rescue as well as disaster response applications
  • 20. Inventions – Optics Overview:A 3D imaging laser system that uses a simple lens system to simultaneously generate a High-resolution, real-time three-dimensional imaging one-dimensional or two-dimensional array of optical (light) spots to illuminate an object, surface or image to generate a topographic profile. Overview: Cost effective method for high precision polishing to shape optical surfaces by employing an Electrochemically Enhanced Mechanical Polishing (EEMP) electrochemical and mechanical shaping / polishing method
  • 21. Inventions – Energy Overview: AirborneWind Energy (AWE) vehicles use the wind to generate power at higher altitudes; Kite-like Wind Power Generation Control System this invention maximizes and optimizes AWE power generation Overview: A solid oxide fuel cell capable of power densities 5X of a normal power cell due to a unique fabrication High-Power Density Solid Oxide Fuel Cell and Fabrication Process process utilizing a freeze-tape casting method
  • 22. Inventions – Materials and Coatings Overview: Novel use of laser surface pattering and chemical film coatings to create surfaces resistant Surface Particle Contamination Mitigation Methods to water, dust, organic growth, and other surface contaminants Overview: Liquid and micro-particle powder coating applied on the surface of reinforced concrete for Liquid Coating for Corrosion Prevention in Rebar corrosion prevention and structural integrity in steel rebars
  • 23. Unique  Inventions,  Incredible  Deal  Flow   Example NASA Robotics Invention Overview: Rugged, lightweight, small, autonomous robot excavator used in sites such as RASSOR Robotic Excavator high-risk or inaccessible mining, search and rescue, as well as disaster response applications Only invention to exploit $25 quadrillion extraplanetary mining industry; $200B to $1T of value in just one asteroid TRL 9, space-flight tested, $35.8M taxpayer dollars invested in R&D Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission 11 more late-stage inventions: • Focused on space technologies, precision medicine, clean energy, and others • Selected from NASA portfolio of 24K+ inventions: 100+ commercially viablespace inventions; 300+ precision medicine Expanding portfolio: patents and inventions from DoD, DoE, DARPA, Navy and other government- funded agencies Low deal flow: currently only ~90 VC-backed space companies from 2000-2015 Opportunity: develop world-changing technologies, create new industries and ecosystems, drive outsized growth and returns
  • 24. Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission Startup Challenge Evolution to Fund
  • 25. Early investors end up <20% minority interest, often without enough power to kill the “walkingdead” & redeploy Investors attempt to short list the best out of the noise through quality of team, traction and solid plan Investors often deal with unsophisticated founders who don’t understand governance or valuation Early Stage investors often receive 100’s if not 1000’s of pitch decks, emails or via fast pitch events for dealfow Invest (1-5) Term Sheet (5-10) Diligence (10-25) Pitch (100’s) Diligence (1000’s) Invest (2-5) Source BPs & Teams/Tech (5-10) Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission Solving  Early  Stage  Investing  Problems
  • 26. Quality Strategic Deal Flow Struggles to find worthy opportunities matched to strategic needs Capital Efficiency Most IP is capital & time intensive. Cost reduction levers are key, e.g., startup nimbleness and regional advantages Skilled Startup Teams Seasoned entrepreneurs seeded in teams prevent rooky mistakes Accelerated Results Teams require funding and go around the US to raise it for 6-12months Commercialization Risks Inventions require de-risking – lead to high failure rates Favorable Terms Licensing agreements often have onerous deal terms and are quick to negotiate R&D$ Productivity Size$of$R&D$Organization Large& Pharma&Co’s Optimal& Size 89% 92% 65% 21% 52% 34% VALUE&OPPORTUNITY&ANALYSIS YOUR&PRODUCT adventure independance security sensuality confidence power comfort safety ease3of3use visual auditory tactile olfactory taste point3in3time sense3of3place personality social environmental reliable enabling craftmanship durability LOW MED HIGH Emotion Ergonomics Aesthetics Identity Impact Core4Tech. Quality Profit4Impact Brand4Impact Extendable COMPETITION&(OR&NEXT&PRODUCT) adventure independance security sensualtiy confidence power comfort safety ease3of3use visual auditory tactile olfactory taste point3in3time sense3of3place personality social environmental reliable enabling craftmanship durability LOW MED HIGH Emotion Ergonomics Aesthetics Identity Impact Core4Tech. Quality Profit4Impact Brand4Impact Extendable Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission Gazelle  Solves  Pipeline  Challenges
  • 27. An early stage venture capital fund that leverages exclusive, low-cost access to a large portfolio of risk mitigated inventions combined with a proven and award winning “Startup Challenge Accelerator” to rapidly launch new capital efficient companies and grow jobs. Gazelle Futures Mission Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
  • 28. Financial Impact $90MEndowment 20Companies 56%+Fund IRR Investing + “venture philanthropy” of LP’s 50% split carrycreates a sustainable source of future funding Proven, award winning accelerator matches inventions to region’s strengths & significantly increases new startups Securing the majority of equity at the early stage captures all value creation, resulting in strong for all investors Even with highly conservative assumption of 90% failure failure rate, startups jobs generate a large commerce impactin area $600M Social Impact $180MInvestor Returns Limited Partners that invest capital are positioned to realize strong exit return multiples over the 10 yr life GDP Impact 82%Employment Challenge graduates have attractive entrepreneurial skills that lead to high job placement success in market 2500Trained Over 500+ people per year x 5 years receive advanced STEM training during the 12 month accelerator process 18KTotal Jobs Growing Life Science oriented startups creates a large multiplier effect, leading to job growth throughout the local ecosystem Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission Measurable  Impact  with  $20MM  Fund Target  Case
  • 29. Gazelle Futures Fund Overview 9 yr | 4 yr Investing Fund Horizon Match to Region Strengths Market Focus Seed to Series A Stage Focus $20MM Segments ($100MM Total) Total Fund Under-valued Regions Geographic Focus Performance Based GP Carry Interest 5x + Exit Targets Outsize Returns $200K - $1.2MM Investment Size 10-20 Seed | Series A Investments Substantial 100% Equity Positions Gazelle Futures| 9508 Burning Tree Road; Bethesda, MD 20817 USA rht@gazellefutures.com | (202) 438-2208 | www.gazellefutures.com Fund Mission De-risked, Capital Efficient § Builds on successful startup model § Breast Cancer Startup Challenge, Neuro Startup Challenge § Kaufmann Foundation proprietary research § STEM and entrepreneurship education Differentiation Unique Deal/Team Access § Unprecedented no/low-cost licensing access § De-risked portfolio of 24,000 NIH & NASA inventions § Crowd source global talent Investment Strategy “Lead Seed”-Founder Friendly § Up to $1MM+ seed investments § Founder friendly support from industry experts § lowest cost/% ownership and maintaining substantial positions through future dilutive rounds Social Impact Financials 100% Performance Based § Performance based IRR goals § Creation of regional endowment § 2.5% mgmt fee for Challenge Accelerator. Confidential & Proprietary | DO NOT DISTRIBUTE Experienced Investment Team Rosemarie H. Truman Managing Partner - CEO, Center for Advancing Innovation - Launched 33 Award Winning NIH Startups - 22 Yrs & $210B+ F500 Growth Strategy - IBM, Goldman, JP Morgan, E&Y,Oracle Nick Donafrio Board Chairman - IBM VP of Global Innovation and Technology for 35 years (IBM Watson) - Industry and thought leader - MITRE, Liberty Mutual, Wigix, others
  • 30. BENEFITS Disruptive  Investors § Outsized  returns  and  IRRs § Diverse  invention   portfolio:  energy,   personalized  medicine,   adv.  manufacturing § Performance  driven  fund § Proven,  efficient,  data   driven,  award-­‐winning,   investment  model § Impact  investing  with   multiplier  effect   § Network  expansion  – AUTM,  BIO,  White  House,   etc. Government  and Tech  Transfer: § Multiplier  effect  in   impacting  public  health,   energy,  medicine,  other   sectors § Supports  the  Presidential   Memorandum  and   Startup  America § New  paradigm  of   commercializing   inventions § Expanded  private   funding  for  R&D § New  platform  to  train   the  next  generation  of   scientists § Support  STEM  education Powering  Growth: § Train  1000s new  STEM  entrepreneurs § Create  100s  startups § Create  millions  of  new  jobs § Support  regional  sustainability § Contribute  to  GDP  through  new  products CAI  and  Gazelle  Futures: § Drive  and  accelerate  high  growth  business § Increase  the  volume  of  commercialization § Accelerate  ground  breaking  innovations Key  Takeaways  for  Stakeholders
  • 31. Rosemarie Truman: (202) 438-2208 twitter.com/centerinnovate www.thecenterforadvancinginnovation.org https://www.linkedin.com/company/the-center-for-advancing-innovation-inc- ?trk=biz-companies-cym Contact 9508 Burning Tree Road, Bethesda, MD 20817 The Center for Advancing Innovation, INC Gazelle Futures, INC Rosemarie H. Truman | Founder and CEO Sourav Sinha | Entrepreneur in Residence rt@thecenterforadvancinginnovation.org
  • 32. Key Takeaways Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission § YOU can do this too! We’ve built a nice platform AND have lessons learned § Join the SPACE RACE; build a team; be a judge; advise the challenge; mentor a team § GAZELLE is seeking strategic partnerships & advisors; please connect with us if interested THANK YOU ROSEMARIE TRUMAN, FOUNDER AND CEO SOURAV SINHA, ENTREPRENEUR IN RESIDENCE THE CENTER FOR ADVANCING INNOVATION RT@THECENTERFORADVANCINGINNOVATION.ORG TEXT: 202 438 2208
  • 33. Healthy Cell Cancer Cell No Effect Azonafide Kills Cell
  • 34. § Winner of Breast Cancer Startup Challenge by the National Cancer Institute (NCI) § Awarded grants from Avon Foundation for Women, NASA/Center for the Advancement of Science in Space (CASIS), and the Horizon 2020 Program (UK) § Winner of MassChallenge & MassBio 2014 Startup Accelerators § Winner of the Rice Business Plan Competition § Raised seed financing, currently raising a bridge round § Partnered with 14 pharma partners all over the world § Partnered with 6 academic labs all over the world § Offices in Boston and London § Closed Startup Exclusive Option License Agreement with the NCI § Showcases: TEDMED, World ADC Summit, Engage Forum Tokyo, Protein & Antibody Engineering Summit (Shanghai & Boston ’15) Team Progress
  • 35. Startup Challenge Evolution to Fund CAI$performs due$diligence on$exclusive$access$ invention$portfolio CAI$runs$ challenge/accelerator,$ crowd;sourcing$startup$ teams.$Teams$apply$ for$SBIR$funds CAI$selects$winning$ business$plans$and$ teamsC$CAI$facilitates$ licensing$agreement Gazelle$exclusive$$ deal$with$CAI$to$ perform$due$ diligence Gazelle$creates$ company$vehicle$for$ inventions$– and$ owns$100% Gazelle$funds$ startup$leadership$ and$provides$first$ tranche$fundingC$ owns$55%$equity Space&Race Gazelle$performs$ ongoing$governance$ and$has$strict$go/no; go$milestones Gazelle$puts$in$ Series$A$fundingC$ funding$is$matched.$ Valuations$double Liquidity$Event$ Gazelle$pays$out$ to$LPs Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission
  • 36. Who Can Join the SPACE RACE? Recruiting Multi-Disciplinary Teams Team Design: Mandatory Requirements Challenge  TEAM Business Legal Invention Specific   Technical   Seasoned   Entrepreneur Typical Participation Students: • Graduate and undergraduate students • Post-docs as well as those in residency Others - match skill sets of mentors to invention and team: • Business Development Leaders from Large Companies • Key Opinion Leaders • FDA/Regulatory • Venture Capitalists • Clinical Research Outsourcer (CRO) • Over  18  years  old* • At  least  three  students  on  the  team *and youngerwith parent’spermission as long as the rest of the team meets requirements Confidential & Proprietary to The Center for Advancing Innovation. Do Not Distribute