1. ®
Alex Team
Rana EL.Abd
®

2. © Sun Pharmaceutical Industries Limited. All Rights Reserved. 2

3. © Sun Pharmaceutical Industries Limited. All Rights Reserved. 3
Products sold in
over 150 countries
Over 3000 products 45 factories

4.  Active Constituent: Risperidone
 Concentration : 2 mg – 4 mg
 Use : Anti-psychotic
 Route of administration : Oral
 Dosage form : 10 Scored Tab
 Price : 2 mg (30 L.E)
4 mg (45 L.E)
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Zesperone®

5. © Sun Pharmaceutical Industries Limited. All Rights Reserved. 5

6. Advantages
• More Selective in its action
• Less EPS
• No effect on prolactin production
Zesperone®

7. 7
FDA approval
(Aug 2010)

8. CATIE Study

9. Body Weight: Change from Baseline
0%
10%
20%
30%
40%
Risperidone Olanzapine
Glucose: Change from Baseline
0.0
5.0
10.0
15.0
Risperidone Quitapine Olanzapine
WeightGain>7%Exposure-Adjusted
Mean(mg/dL) Quitapine

10. Fasting Triglycerides: Change from Baseline
-20.0
-5.0
10.0
25.0
40.0
Risperidone
Exposure-Adjusted
Mean(mg/dL)
Olanzapine

12.  Active Constituent: Sertraline HCL
 Concentration : 100 mg
 Uses : Depression - OCD
 Route of administration : Oral
 Dosage form : Film coated tablets ( 10 Scored Tab )
 Dose : 50mg/day ( may increases ) .. Max. 200 mg/day
 Price : 40 L.E
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13. © Sun Pharmaceutical Industries Limited. All Rights Reserved. 13

14. Advantages
• More tolerated
• Less sedation
• Safe
• No CVS side effects
• No Atropine like effects
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15. FDA approval
(Feb 2007)

16. Published online January 29, 2009 DOI:10.1016/S0140-6736(09)60046-5
Lancet
Meta analysis in review

17. Meta analysis in review
• 117 randomised trials
• 25,928 participants from 1991 up to Nov 30, 2007 .
• Treatment of unipolar major depression in adults using :
Bupropion, Citalopram, Duloxetine, Escitalopram, Fluoxetine,
Fluvoxamine,Milnacipran, Mirtazapine, Paroxetine, Reboxetine, Sertraline, and
Venlafaxine.
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 Methodology
Meta analysis in review

18. Meta analysis in review
• Sertraline might be the best choice in depression treatment.
• The most favourable
balance between benefit acceptability, and acquisition cost.
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 Findings
Meta analysis in review

19. Thank You
Rana ELabd
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Tel Direct : +91 22 66455645
Mobile : 01002133790
rana.elabd@sunpharma.com
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