2. Enteric Nervous System
• GIT( Gut)
Central Nervous System (CNS)
• Brain
• Spinal cord
Peripheral Nervous System (PNS)
• Cranial nerves (12 pairs)
• Spinal nerves (31 pairs)
3. Spinal cord
Lower elongated part of
central nervous system
Cylindrical in shape
Extends from upper border
of the 1st cervical vertebrae
to the lower border of 1st
lumbar vertebrae L1 in adult
L3 (newborn)
4. Conus medullaris: tapered inferior
end.
Cauda equina: origins of spinal
nerves extending inferiorly from
lumbosacral enlargement and conus
medullaris.
Filum terminale
median ligament of pia mater
extending from conus medularis to
first coccygeal vertebra.
6. Provide physical stability and shock absorption
Three layers
◦ Dura mater
◦ Arachnoid mater
◦ Pia mater
Spaces
◦ Epidural: anesthesia injected. Contains blood vessels, areolar
connective tissue and fat.
◦ Subdural: serous fluid
◦ Subarachnoid: CSF and blood vessels within web-like strands of
arachnoid tissue.
7. The adult spinal cord
terminates at the level of
the first lumbar vertebra
(L1)
Lumber puncture in
adult is done in
between L3-L4.
8. 8
White matter = myelinated processes (white in
color)
Gray matter = nerve cell bodies, dendrites, axon
terminals, bundles of unmyelinated axons and
neuroglia (gray color)
9. H-shaped pillar with anterior &
posterior gray horns
United by gray commissure
containing the central canal
Lateral gray column (horn)
present in thoracic & upper
lumbar segments
Amount of gray matter related
to the amount of muscle
innervated
Consists of nerve cells,
neuroglia, blood vessels
16. The basic classifications of a spinal cord injury are:
Tetraplegia (Quadriplegia)
Injury to the spinal cord in the cervical region with associated loss of
muscle strength in all four extremities.
Paraplegia :- Injury to the spinal cord in the thoracic, lumbar, or
sacral segments, including the cauda equina and conus medullaris,
are associated with loss of muscle strength in the lower extremities.
17. Vessels of the spinal cord
Anterior spinal vessels
Posterior spinal vessels
Radicular vessels
18. Anterior spinal artery (Medial Medullary syndrome)
Supply anterior
⅔ of spinal cord
Posterior spinal arterie
Arise from vertebral artery or
(PICA)
Supply posterior ⅓ of spinal cord
19.
20. 8 pairs of cervical spinal
nerves; *C1-C8
12 pairs of thoracic spinal
nerves; T1-T12
5 pairs of lumbar spinal
nerves; L1-L5
5 pairs of sacral spinal
nerves; S1-S5
1 pair of coccygeal spinal
nerves; C0
21. Thirty-one pairs of spinal nerves
First pair exit vertebral column between skull and
atlas.
Last four pair exit via the sacral foramina
Others exit through inter-vertebral foramina
12-
21
22. Spinal nerves indicated by capital letter and number
Dermatomal map: skin area supplied with sensory
innervation by spinal nerves
12-
22
24. Complex network of ventral primary divisions
of spinal nerves
Four large plexuses
Ventral rami of C1-C4= cervical plexus
Ventral rami of C5-T1= brachial plexus
Ventral rami of L1-L4= lumbar plexus
Ventral rami of L4-S4= sacral plexus
25. S4-S5; coccygeal nerve
Muscles of pelvic floor
Sensory information from skin over coccyx
26. C1-C4
Innervates superficial neck structures, skin of neck,
posterior portion of head
Ansa cervicalis: loop between C2 and C3
Phrenic nerve
◦ From C3-C5 (cervical and brachial plexuses)
◦ Innervate diaphragm
12-
26
27.
28. Nerve plexus of C5- C8 and T1
Five ventral rami form three trunks that separate
into six divisions then form cords that give rise to:
Branches/nerves
◦ Axillary
◦ Radial
◦ Musculocutaneous
◦ Ulnar
◦ Median
◦ Smaller nerves such as pectoral, long thoracic,
thoracodorsal, subscapular, suprascapular
12-
28
32. Movements at
wrist, fingers,
hand
Skin- medial 1/3
of hand, little
finger, and medial
½ of ring finger
12-
32
33. Movement of hand,
wrist, fingers,
thumb
Skin- Lateral 2/3
palm, thumb, index
and middle fingers;
lateral ½ of ring
finger and dorsal
tips of same fingers
12-
33
34.
35. Lumbar plexus: ventral
rami of L1-L4
Sacral plexus: ventral rami
of L4-S4
Usually considered
together because of their
close relationship
Four major nerves exit and
enter lower limb
◦ Obturator
◦ Femoral
◦ Tibial
◦ Common fibular (peroneal)
12-
35
36. Adduction of the
thigh and knee
Skin- superior
middle side of
thigh
12-
36
37. Movements of hip
and knee:
iliopsoas,
sartorius,
quadriceps
femoris
Skin- anterior and
lateral thigh;
medial leg and
foot
12-
37
38. The two nerves
together referred to
as the sciatic
(ischiadic) nerve
Tibial
◦ Movement of hip, knee,
foot, toes
◦ Skin: none
◦ Branches are medial
and lateral plantar
nerves, sural nerve
12-
38
39. Common fibular
◦ Anterior and lateral
muscles of the leg
and foot
◦ Skin distribution:
lateral and anterior
leg and dorsum of
the foot.
◦ Branches are deep
and superficial fibular
(peroneal) nerves
12-
39
40. General disorders
◦ Anesthesia: loss of sensation
Hyperesthesia: increased sensitivity to pain, pressure,
light
Paresthesia: tingling, prickling, burning
Neuralgia: nerve inflammation causing stabbing pain
Sciatica: pain radiating down back of thigh and leg
Infections
◦ Herpes: skin lesions
◦ Shingles or herpes zoster: adult disease of
chickenpox
◦ Poliomyelitis: infantile paralysis
◦ Anesthetic leprosy: bacterial infection of peripheral
nerves
Genetic and autoimmune disorders
◦ Myasthenia gravis: results in fatigue and muscular
weakness due to inadequate ACh receptors