The Therapeutic Transformation of Bladder Cancer: Understanding Immune-, Targeted-, and Antibody-Based Models for Patient Care
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Chair, Matthew D. Galsky, MD, discusses bladder cancer in this CME/MOC activity titled “The Therapeutic Transformation of Bladder Cancer: Understanding Immune-, Targeted-, and Antibody-Based Models for Patient Care.” For the full presentation, downloadable Practice Aids, monograph, and complete CME/MOC information, and to apply for credit, please visit us at https://bit.ly/2RSWhFH. CME/MOC credit will be available until April 19, 2023.
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Chair and Presenters, Yelena Y. Janjigian*, MD, Shubham Pant, MD, and John Strickler, MD, discuss HER2+ GI malignancies in this CME/MOC/NCPD/AAPA/IPCE activity titled “Precision Tactics in HER2-Positive GI Malignancies: Capitalizing on HER2-Targeted Regimens to Improve Outcomes for Gastric/GEJ Cancers, CRC, and BTC.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at https://bit.ly/49K4Qcb. CME/MOC/NCPD/AAPA/IPCE credit will be available until June 30, 2025.Anticoagulation Therapy in NVAF: A Quality Improvement Initiative
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Chair Kun "Kevin" Xiang, MD, PhD, discusses atrial fibrillation in this CME/MOC/NCPD/CPE activity titled “Anticoagulation Therapy in NVAF: A Quality Improvement Initiative.” For the full presentation, downloadable Practice Aids, monograph, and complete CME/MOC/NCPD/CPE information, and to apply for credit, please visit us at https://bit.ly/2UoPplb. CME/MOC/NCPD/CPE credit will be available until June 12, 2025.Supporting Patient-Centered Care in Generalized Pustular Psoriasis: Communica...
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Chair and Presenters Professor Stephen Johnston, MA, PhD, Patrick Neven, MD, PhD, and Joyce O’Shaughnessy, MD, discuss breast cancer in this CME/MOC/CPD/NCPD/CPE/AAPA activity titled “Safeguarding Patients With HR+, HER2-, High-Risk, Early Breast Cancer: A Practical Roadmap for CDK4/6 Inhibition in the Adjuvant Setting.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/CPD/NCPD/CPE/AAPA information, and to apply for credit, please visit us at https://bit.ly/49HZ5fH. CME/MOC/CPD/NCPD/CPE/AAPA credit will be available until June 21, 2025.Cases in the Community: Optimizing Treatment and Considering Weight Managemen...
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Chair, Javier Morales, MD, FACP, FACE, discusses Type 2 diabetes in this CME/CE/AAPA activity titled “Cases in the Community: Optimizing Treatment and Considering Weight Management as a Primary Goal in People with T2DM.” For the full presentation, downloadable Practice Aids, and complete CME/CE/AAPA information, and to apply for credit, please visit us at . CME/CE/AAPA credit will be available until June 11, 2025.Redefining Frontlines in CLL: Key Questions on the Role of CIT, BTKi Standard...
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Chair, Nicole Lamanna, MD, discusses chronic lymphocytic leukemia in this CME activity titled “Redefining Frontlines in CLL: Key Questions on the Role of CIT, BTKi Standards, and Innovative BTKi Combinations.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at https://bit.ly/49Mazi3. CME credit will be available until June 11, 2025.Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neu...
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Co-Chairs, Val J. Lowe, MD, and Cyrus A. Raji, MD, PhD, discuss Alzheimer’s disease in this CME/AAPA activity titled “Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neuroradiology in Diagnosis and Treatment.” For the full presentation, downloadable Practice Aids, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/3PvVY25. CME/AAPA credit will be available until June 28, 2025.Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neu...
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Co-Chairs, Val J. Lowe, MD, and Cyrus A. Raji, MD, PhD, prepared useful Practice Aids pertaining to Alzheimer’s disease for this CME/AAPA activity titled “Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neuroradiology in Diagnosis and Treatment.” For the full presentation, downloadable Practice Aids, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/3PvVY25. CME/AAPA credit will be available until June 28, 2025.Adapting HIV Treatment for People With Substance Use Disorder
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Chair, Monica Gandhi, MD, MPH, prepared useful Practice Aids pertaining to HIV for this CME/MOC/CE/AAPA activity titled “Adapting HIV Treatment for People With Substance Use Disorder.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/CE/AAPA information, and to apply for credit, please visit us at https://bit.ly/49hgPxT. CME/MOC/CE/AAPA credit will be available until June 4, 2025.Adapting HIV Treatment for People With Substance Use Disorder
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Chair, Monica Gandhi, MD, MPH, discusses HIV in this CME/MOC/CE/AAPA activity titled “Adapting HIV Treatment for People With Substance Use Disorder.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/CE/AAPA information, and to apply for credit, please visit us at https://bit.ly/49hgPxT. CME/MOC/CE/AAPA credit will be available until June 4, 2025.Aligning Clinical Practice With Emerging Evidence: Navigating the Rapidly Evo...
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Chair, Carla M. Nester, MD, MSA, FASN, discusses glomerular kidney disease in this CME activity titled “Aligning Clinical Practice With Emerging Evidence: Navigating the Rapidly Evolving Landscape of Glomerular Kidney Disease Management.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at https://bit.ly/3wJPTs1. CME credit will be available until June 4, 2025.Experts vs AI: Who Is Better at Monitoring and Treating MASLD and MASH?
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Chair and Presenter Rohit Loomba, MD, MHSc, and Alina M. Allen, MD, MS, discuss metabolic dysfunction–associated steatohepatitis in this CME activity titled “Experts vs AI: Who Is Better at Monitoring and Treating MASLD and MASH?.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at https://bit.ly/3O53xMy. CME credit will be available until June 19, 2025.Five Steps for Integrating BCMA Bispecific Innovations: From Clinical Data to...
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Co-Chairs, Prof. Mohamad Mohty, MD, PhD, and Caitlin Costello, MD, discuss refractory multiple myeloma in this CME/CPD activity titled “Five Steps for Integrating BCMA Bispecific Innovations: From Clinical Data to Clinical Practice in RRMM.” For the full presentation, downloadable Practice Aids, and complete CME/CPD information, and to apply for credit, please visit us at https://bit.ly/3UFL0dt. CME/CPD credit will be available until 5 June 2025.Stories Behind the Science in Non-Cystic Fibrosis Bronchiectasis: Understandi...
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Co-Chairs, Doreen J. Addrizzo-Harris, MD, and Cedric "Jamie" Rutland, MD, discuss non-cystic fibrosis bronchiectasis in this CME/MOC/AAPA activity titled “Stories Behind the Science in Non-Cystic Fibrosis Bronchiectasis: Understanding Disease Burden, Diagnosing Early, and Looking Toward New Management Options.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at https://bit.ly/3KlxjL9. CME/MOC/AAPA credit will be available until June 19, 2025.Establishing the Collaborative Benchmark for HCC Care: Critical Discussions B...
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Co-Chairs Riad Salem, MD, MBA, and Mark Yarchoan, MD, discuss liver cancer in this CME/MOC activity titled “Establishing the Collaborative Benchmark for HCC Care: Critical Discussions Between Interventional Radiologists and Oncologists to Maximize Therapeutic Benefit.” For the full presentation, downloadable Practice Aids, and complete CME/MOC information, and to apply for credit, please visit us at https://bit.ly/3IOQvQ6. CME/MOC credit will be available until June 14, 2025.More from PVI, PeerView Institute for Medical Education (20)
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Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
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CLASSIFICATION OF H1 ANTIHISTAMINICS-
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1)HIGHLY SEDATIVE-DIPHENHYDRAMINE,DIMENHYDRINATE,PROMETHAZINE,HYDROXYZINE 2)MODERATELY SEDATIVE- PHENARIMINE,CYPROHEPTADINE, MECLIZINE,CINNARIZINE
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AZELASTINE,MIZOLASTINE,EBASTINE,RUPATADINE. Mechanism of action of 2nd generation antihistaminics-
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Pharmacological actions-
Antagonism of histamine-The H1 antagonists effectively block histamine induced bronchoconstriction, contraction of intestinal and other smooth muscle and triple response especially wheal, flare and itch. Constriction of larger blood vessel by histamine is also antagonized.
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Receptor Discordance in Breast Carcinoma During the Course of Life
Definition:
Receptor discordance refers to changes in the status of hormone receptors (estrogen receptor ERα, progesterone receptor PgR, and HER2) in breast cancer tumors over time or between primary and metastatic sites.
Causes:
Tumor Evolution:
Genetic and epigenetic changes during tumor progression can lead to alterations in receptor status.
Treatment Effects:
Therapies, especially endocrine and targeted therapies, can selectively pressure tumor cells, causing shifts in receptor expression.
Heterogeneity:
Inherent heterogeneity within the tumor can result in subpopulations of cells with different receptor statuses.
Impact on Treatment:
Therapeutic Resistance:
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HER2 discordance affects the efficacy of HER2-targeted treatments.
Treatment Adjustment:
Regular reassessment of receptor status may be necessary to adjust treatment strategies appropriately.
Clinical Implications:
Prognosis:
Receptor discordance is often associated with a poorer prognosis.
Biopsies:
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Monitoring:
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Understanding and managing receptor discordance is essential for optimizing treatment outcomes and improving the prognosis for breast cancer patients.
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