Insulin producing cells grown in lab

1. Breakthrough: Insulin-
producing cells grown in lab
May Lead To Personalised Cell Therapy For Diabetics
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2. Contd…
Scientists have successfully converted human skin cells into functional
pancreatic cells, a breakthrough that may lead to a personalised cell therapy
for diabetics, ending the need for insulin jabs. The new cells produced insulin
in response to changes in glucose levels, and when transplanted into mice,
protected the animals from developing diabetes, researchers said. The study
will allow scientists to scale up pancreatic cell production and manufacture
trillions of the target cells in a controlled manner.
“Our results demonstrate for the first time that human adult skin cells can be
used to efficiently and rapidly generate functional pancreatic cells that
behave similar to human beta cells,“ said Matthias Hebrok, director of the
Diabetes Centre at University of California. “This finding opens up the
opportunity for the analysis of patient-specific pancreatic beta cell
properties and the optimisation of cell therapy approaches,“ said Hebrok.Brought to you by
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3. Contd…
In the study , the scientists first used pharmaceutical and genetic molecules to
reprogramme skin cells into endoderm progenitor cells -early developmental cells that
have already been designated to mature into one of a number of diffe rent types of organs.
With this method, the cells do not have to be taken all the way back to a pluripotent stem
cell state, meaning the scientists can turn them into pancreatic cells faster. After another
four molecules were added, the endoderm cells divided rapidly, allowing more than a
trillion-fold expansion. The scientists then progressed these endoderm cells two more
steps, first into pancreatic precursor cells, and then into fully-functional pancreatic beta
cells.
“The final step was the most unique and the most difficult, as molecules had not
previously been identified that could take reprogrammed cells the final step to functional
pancreatic cells in a dish,“ said first author Saiyong Zhu, a postdoctoral researcher at the
Gladstone Institute of Cardiovascular Disease.
“This cellular reprogramming and expansion paradigm is more sustainable and scalable
than previous methods,“ said Sheng Ding, a scientist.
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