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Deep Dive to Acute Coronary
Syndrome
dr. Edrian, SpJP (K), FIHA
Outline
• Definisi ACS
• Patofisiologi
• Penegakan diagnosis dan pembagian
• Tatalaksana (case-based)
Sekumpulan gejala dan tanda klinis
yang sesuai dengan iskemia miokard
akut.
Definisi
Proses Aterosklerosis yang
Progresif
Normal
Fatty
streak
Fibrous
plaque
Athero-
sclerotic
plaque
Plaque
rupture/
fissure &
thrombosis MI
Ischemic
stroke/TIA
Critical leg
ischemia
Keluhan klinis (-)
Kematian
Akibat Kardiovaskular
Bertambahnya Umur
Angina Stabil
Intermittent claudication
Angina Tak
Stabil
}ACS
ACS, acute coronary syndrome; TIA, transient ischemic attack
Filippo Crea. Circulation. Acute Coronary Syndromes, Volume: 136,
Issue: 12, Pages: 1155-1166, DOI:
(10.1161/CIRCULATIONAHA.117.029870) © 2017 American Heart Association, Inc.
Endorsed by the American Society of Echocardiography, American College of
Chest Physicians, Society for Academic Emergency Medicine, Society of
Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic
Resonance
2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR
Guideline for the Evaluation and Diagnosis of Chest
Pain
Figure 1. Take-Home Messages for the
Evaluation and Diagnosis of Chest Pain
7
Figure 2. Index of Suspicion That Chest “Pain” Is
Ischemic in Origin on the Basis of Commonly Used
Descriptors.
8
Table 3. Chest Pain Characteristics and
Corresponding Causes
9
Nature
Anginal symptoms are perceived as retrosternal chest discomfort (e.g., pain, discomfort, heaviness, tightness, pressure, constriction, squeezing) (Section 1.4.2, Defining
Chest Pain).
Sharp chest pain that increases with inspiration and lying supine is unlikely related to ischemic heart disease (e.g., these symptoms usually occur with acute pericarditis).
Onset and duration
Anginal symptoms gradually build in intensity over a few minutes.
Sudden onset of ripping chest pain (with radiation to the upper or lower back) is unlikely to be anginal and is suspicious of an acute aortic syndrome.
Fleeting chest pain—of few seconds’ duration—is unlikely to be related to ischemic heart disease.
Location and radiation
Pain that can be localized to a very limited area and pain radiating to below the umbilicus or hip are unlikely related to myocardial ischemia.
Anamnesis:
• Onset nyeri (penting untuk STEMI apakah <12 jam)
• Provocation : aktivitas apa yang mencetuskan nyeri dada
• Quality / Deskripsi nyeri: berat di dada, atau tidak khas seperti sesak
• Radiation / Penjalaran nyeri: ke lengan kiri, bahu, punggung,
epigastrium, leher rasa tercekik atau rahang bawah
• Severity : derajat nyeri dada saat ini (skala 1-10)
• Timing / Lama nyeri: lebih dari 20 menit. Pada STEMI tidak hilang
dengan istirahat atau nitrat SL
• Gejala sistemik : mual, muntah, keringat dingin, berdebar
• Faktor risiko PJK : merokok, hipertensi, DM, dislipidemia, riw.keluarga
dengan PJK prematur
Diagnosis Sindroma Koroner Akut
Considerations for Older Patients
With Chest Pain
11
Recommendation for Considerations for Older Patients With Chest Pain
COR LOE Recommendation
1 C-LD
1. In patients with chest pain who are >75 years of age, ACS should be
considered when accompanying symptoms such as shortness of breath,
syncope, or acute delirium are present, or when an unexplained fall has
occurred.
PEMERIKSAAN FISIK:
• Fisik secara umum normal
• Bila ada komplikasi dapat ditemukan
takipneu, taki/bradikardi, gallop S4, murmur
sistolik (regurgitasi mitral akut/ rupture IVS),
ronkhi basah halus paru, akral dingin
Diagnosis Sindroma Koroner Akut
EKG:
Diagnosis Sindroma Koroner Akut
Pembagian
Morris F, Brady WJ. BMJ 2012;324;831-834 15
5- 30 min setelah onset
1-2 jam
2-6 jam setelah
• Resolusi segmen - - anterior hingga 2 minggu;
posterior > 2 minggu
• Gel T resolusi : berbulan-bulan
Evolusi EKG pada STEMI
LABORATORIUM:
• CKMB
• Troponin
Diagnosis Sindroma Koroner Akut
Hs-Troponin
17
Patients With Acute Chest Pain and Suspected
ACS (Not Including STEMI) (cont..)
1 C-LD
3. To standardize the detection and differentiation of myocardial injury in
patients presenting with acute chest pain and suspected ACS, institutions
should implement a CDP that includes a protocol for troponin sampling based
on their particular assay.
1 C-LD
4. In patients with acute chest pain and suspected ACS, previous testing when
available should be considered and incorporated into CDPs.
2a B-NR
5. For patients with acute chest pain, a normal ECG, and symptoms suggestive
of ACS that began at least 3 hours before ED arrival, a single hs-cTn
concentration that is below the limit of detection on initial measurement (time
zero) is reasonable to exclude myocardial injury.
copyright 2006
www.brainybetty.com
11/26/2015 18
A
L
G
O
R
I
T
M
E
• Seorang laki-laki 61th datang ke UGD dengan keluhan nyeri
dada di bagian tengah seperti ditindih benda berat
• Kesadaran pasien baik TD 80/50, nadi 45x/m,
pernapasan 20x/m, SaO2 96%
• Nyeri dada muncul sekitar 5 jam yll.
• terasa menjalar ke lengan kiri.
• skala nyeri 4/10
• disertai keringat dingin dan pandangan melayang
• Riwayat merokok 1 bungkus sehari, hipertensi, kolesterol
tinggi
• pemeriksaan fisik dalam batas normal
Ilustrasi kasus
EKG
STEMI inferior + total
av blok + syok
kardiogenik
Terapi?
Terapi Fibrinolisis :
Kontraindikasi
PPCI +TPM
• Seorang laki-laki 65th datang ke UGD dengan keluhan
nyeri dada kiri disertai rasa sesak
• Kesadaran CM ; TD 140/50, nadi 45x/m,
pernapasan 20x/m, SaO2 96%
• Nyeri dada muncul sekitar 1 jam yll.
• terasa menjalar ke lengan kiri.
• skala nyeri 6/10
• disertai keringat dingin Riwayat stroke NH 2 thn yll
• pemeriksaan fisik dalam batas normal
Ilustrasi kasus
Severe angina  MO 2x
NSTEMI, very high risk
www.escardio.org/guidelines
2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without
persistent ST-segment elevation (European Heart Journal 2020 - doi/10.1093/eurheartj/ehaa575)
©ESC
Table 7 P2Y12 receptor inhibitors for use in non-ST-segment
elevation acute coronary syndrome patients (2)
Oral administration i.v. administration
Clopidogrel Prasugrel Ticagrelor Cangrelor
(Pretreatment)
-Dose
600 mg LD,
75 mg MD
60 mg LD,
10 (5) mg MD
180 mg LD,
2 × 90 (60) mg
MD
30 µg/kg i.v. bolus,
4 µg/kg/min i.v.
infusion for PCI
Onset of effect Delayed: 2–6 h Rapid: 0.5–4 h Rapid: 0.5–2 h Immediate: 2 min
Offset of
effect
3–10 days 5–10 days 3–4 days 30–60 min
• Diagnosa angina : atipikal chestpain  “non cardiac
chest pain”
• Tatalaksana STEMI  revaskularisasi segera!!
• Tatalaksana NSTEMI  stratifikasi resiko
• Pada pasien ACS (high riks)  membutuhkan
antiplatelet yang potent
Take home massage
Thank You
35
Table 7. Warranty Period for Prior Cardiac Testing
Test Modality Result Warranty Period
Anatomic Normal coronary angiogram
CCTA with no stenosis or plaque
2 y
Stress testing Normal stress test (given adequate
stress)
1 y
CCTA indicates coronary computed tomographic angiography.
36
Figure 5. Chest Pain and Cardiac Testing
Considerations.
The choice of imaging depends on the clinical question of importance, to either a) ascertain the diagnosis of CAD and define coronary anatomy or b) assess ischemia severity among patients with an expected higher
likelihood of ischemia with an abnormal resting ECG or those incapable of performing maximal exercise.
ACS indicates acute coronary syndrome; CAC, coronary artery calcium; CAD, coronary artery disease; and ECG, electrocardiogram.
Please refer to Section 4.1.
For risk assessment in acute chest pain: See Figure 9.
For risk assessment in stable chest pain: See Figure 11.
www.escardio.org/guidelines
2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without
persistent ST-segment elevation (European Heart Journal 2020 - doi/10.1093/eurheartj/ehaa575)
©ESC
Recommendations for antithrombotic treatment in
non-ST-segment elevation acute coronary syndrome patients
undergoing percutaneous coronary intervention (2)
Recommendations Class Level
Antiplatelet treatment (continued)
• Ticagrelor irrespective of the planned treatment strategy
(invasive or conservative) (180 mg LD, 90 mg b.i.d.).
I B
• Clopidogrel (300–600 mg LD, 75 mg daily dose), only when prasugrel or
ticagrelor are not available, cannot be tolerated, or are
contraindicated.
I C
Prasugrel should be considered in preference to ticagrelor for NSTE-ACS
patients who proceed to PCI.
IIa B
GP IIb/IIIa antagonists should be considered for bail-out if there is evidence
of no-reflow or a thrombotic complication.
IIa C

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Deep dive ACS.pptx

  • 1. Deep Dive to Acute Coronary Syndrome dr. Edrian, SpJP (K), FIHA
  • 2. Outline • Definisi ACS • Patofisiologi • Penegakan diagnosis dan pembagian • Tatalaksana (case-based)
  • 3. Sekumpulan gejala dan tanda klinis yang sesuai dengan iskemia miokard akut. Definisi
  • 4. Proses Aterosklerosis yang Progresif Normal Fatty streak Fibrous plaque Athero- sclerotic plaque Plaque rupture/ fissure & thrombosis MI Ischemic stroke/TIA Critical leg ischemia Keluhan klinis (-) Kematian Akibat Kardiovaskular Bertambahnya Umur Angina Stabil Intermittent claudication Angina Tak Stabil }ACS ACS, acute coronary syndrome; TIA, transient ischemic attack
  • 5. Filippo Crea. Circulation. Acute Coronary Syndromes, Volume: 136, Issue: 12, Pages: 1155-1166, DOI: (10.1161/CIRCULATIONAHA.117.029870) © 2017 American Heart Association, Inc.
  • 6. Endorsed by the American Society of Echocardiography, American College of Chest Physicians, Society for Academic Emergency Medicine, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain
  • 7. Figure 1. Take-Home Messages for the Evaluation and Diagnosis of Chest Pain 7
  • 8. Figure 2. Index of Suspicion That Chest “Pain” Is Ischemic in Origin on the Basis of Commonly Used Descriptors. 8
  • 9. Table 3. Chest Pain Characteristics and Corresponding Causes 9 Nature Anginal symptoms are perceived as retrosternal chest discomfort (e.g., pain, discomfort, heaviness, tightness, pressure, constriction, squeezing) (Section 1.4.2, Defining Chest Pain). Sharp chest pain that increases with inspiration and lying supine is unlikely related to ischemic heart disease (e.g., these symptoms usually occur with acute pericarditis). Onset and duration Anginal symptoms gradually build in intensity over a few minutes. Sudden onset of ripping chest pain (with radiation to the upper or lower back) is unlikely to be anginal and is suspicious of an acute aortic syndrome. Fleeting chest pain—of few seconds’ duration—is unlikely to be related to ischemic heart disease. Location and radiation Pain that can be localized to a very limited area and pain radiating to below the umbilicus or hip are unlikely related to myocardial ischemia.
  • 10. Anamnesis: • Onset nyeri (penting untuk STEMI apakah <12 jam) • Provocation : aktivitas apa yang mencetuskan nyeri dada • Quality / Deskripsi nyeri: berat di dada, atau tidak khas seperti sesak • Radiation / Penjalaran nyeri: ke lengan kiri, bahu, punggung, epigastrium, leher rasa tercekik atau rahang bawah • Severity : derajat nyeri dada saat ini (skala 1-10) • Timing / Lama nyeri: lebih dari 20 menit. Pada STEMI tidak hilang dengan istirahat atau nitrat SL • Gejala sistemik : mual, muntah, keringat dingin, berdebar • Faktor risiko PJK : merokok, hipertensi, DM, dislipidemia, riw.keluarga dengan PJK prematur Diagnosis Sindroma Koroner Akut
  • 11. Considerations for Older Patients With Chest Pain 11 Recommendation for Considerations for Older Patients With Chest Pain COR LOE Recommendation 1 C-LD 1. In patients with chest pain who are >75 years of age, ACS should be considered when accompanying symptoms such as shortness of breath, syncope, or acute delirium are present, or when an unexplained fall has occurred.
  • 12. PEMERIKSAAN FISIK: • Fisik secara umum normal • Bila ada komplikasi dapat ditemukan takipneu, taki/bradikardi, gallop S4, murmur sistolik (regurgitasi mitral akut/ rupture IVS), ronkhi basah halus paru, akral dingin Diagnosis Sindroma Koroner Akut
  • 15. Morris F, Brady WJ. BMJ 2012;324;831-834 15 5- 30 min setelah onset 1-2 jam 2-6 jam setelah • Resolusi segmen - - anterior hingga 2 minggu; posterior > 2 minggu • Gel T resolusi : berbulan-bulan Evolusi EKG pada STEMI
  • 16. LABORATORIUM: • CKMB • Troponin Diagnosis Sindroma Koroner Akut Hs-Troponin
  • 17. 17 Patients With Acute Chest Pain and Suspected ACS (Not Including STEMI) (cont..) 1 C-LD 3. To standardize the detection and differentiation of myocardial injury in patients presenting with acute chest pain and suspected ACS, institutions should implement a CDP that includes a protocol for troponin sampling based on their particular assay. 1 C-LD 4. In patients with acute chest pain and suspected ACS, previous testing when available should be considered and incorporated into CDPs. 2a B-NR 5. For patients with acute chest pain, a normal ECG, and symptoms suggestive of ACS that began at least 3 hours before ED arrival, a single hs-cTn concentration that is below the limit of detection on initial measurement (time zero) is reasonable to exclude myocardial injury.
  • 19. • Seorang laki-laki 61th datang ke UGD dengan keluhan nyeri dada di bagian tengah seperti ditindih benda berat • Kesadaran pasien baik TD 80/50, nadi 45x/m, pernapasan 20x/m, SaO2 96% • Nyeri dada muncul sekitar 5 jam yll. • terasa menjalar ke lengan kiri. • skala nyeri 4/10 • disertai keringat dingin dan pandangan melayang • Riwayat merokok 1 bungkus sehari, hipertensi, kolesterol tinggi • pemeriksaan fisik dalam batas normal Ilustrasi kasus
  • 20. EKG STEMI inferior + total av blok + syok kardiogenik Terapi?
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  • 26. • Seorang laki-laki 65th datang ke UGD dengan keluhan nyeri dada kiri disertai rasa sesak • Kesadaran CM ; TD 140/50, nadi 45x/m, pernapasan 20x/m, SaO2 96% • Nyeri dada muncul sekitar 1 jam yll. • terasa menjalar ke lengan kiri. • skala nyeri 6/10 • disertai keringat dingin Riwayat stroke NH 2 thn yll • pemeriksaan fisik dalam batas normal Ilustrasi kasus
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  • 32. www.escardio.org/guidelines 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation (European Heart Journal 2020 - doi/10.1093/eurheartj/ehaa575) ©ESC Table 7 P2Y12 receptor inhibitors for use in non-ST-segment elevation acute coronary syndrome patients (2) Oral administration i.v. administration Clopidogrel Prasugrel Ticagrelor Cangrelor (Pretreatment) -Dose 600 mg LD, 75 mg MD 60 mg LD, 10 (5) mg MD 180 mg LD, 2 × 90 (60) mg MD 30 µg/kg i.v. bolus, 4 µg/kg/min i.v. infusion for PCI Onset of effect Delayed: 2–6 h Rapid: 0.5–4 h Rapid: 0.5–2 h Immediate: 2 min Offset of effect 3–10 days 5–10 days 3–4 days 30–60 min
  • 33. • Diagnosa angina : atipikal chestpain  “non cardiac chest pain” • Tatalaksana STEMI  revaskularisasi segera!! • Tatalaksana NSTEMI  stratifikasi resiko • Pada pasien ACS (high riks)  membutuhkan antiplatelet yang potent Take home massage
  • 35. 35 Table 7. Warranty Period for Prior Cardiac Testing Test Modality Result Warranty Period Anatomic Normal coronary angiogram CCTA with no stenosis or plaque 2 y Stress testing Normal stress test (given adequate stress) 1 y CCTA indicates coronary computed tomographic angiography.
  • 36. 36 Figure 5. Chest Pain and Cardiac Testing Considerations. The choice of imaging depends on the clinical question of importance, to either a) ascertain the diagnosis of CAD and define coronary anatomy or b) assess ischemia severity among patients with an expected higher likelihood of ischemia with an abnormal resting ECG or those incapable of performing maximal exercise. ACS indicates acute coronary syndrome; CAC, coronary artery calcium; CAD, coronary artery disease; and ECG, electrocardiogram. Please refer to Section 4.1. For risk assessment in acute chest pain: See Figure 9. For risk assessment in stable chest pain: See Figure 11.
  • 37. www.escardio.org/guidelines 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation (European Heart Journal 2020 - doi/10.1093/eurheartj/ehaa575) ©ESC Recommendations for antithrombotic treatment in non-ST-segment elevation acute coronary syndrome patients undergoing percutaneous coronary intervention (2) Recommendations Class Level Antiplatelet treatment (continued) • Ticagrelor irrespective of the planned treatment strategy (invasive or conservative) (180 mg LD, 90 mg b.i.d.). I B • Clopidogrel (300–600 mg LD, 75 mg daily dose), only when prasugrel or ticagrelor are not available, cannot be tolerated, or are contraindicated. I C Prasugrel should be considered in preference to ticagrelor for NSTE-ACS patients who proceed to PCI. IIa B GP IIb/IIIa antagonists should be considered for bail-out if there is evidence of no-reflow or a thrombotic complication. IIa C