Keck Year 2 Evidence Based Medicine - Systematic Reviews

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Keck Year 2 Evidence Based Medicine - Systematic Reviews

  1. 1. Systematic Reviews Lynn Kysh, MLIS kysh@usc.edu Information Services Librarian Norris Medical Library
  2. 2. Evidence Pyramid – Publication Types Evidence-Based Guidelines Systematic Review & Metaanalysis Higher Quality of Information Fewer Articles Randomized Controlled Trials Cohort Studies Case Control Studies Lower Quality of Information More Articles Case Series, Case Reports
  3. 3. Agenda • Distinguish a systematic review from a standard literature review • Locate the following in PubMed • Reviews • Systematic Reviews • Meta-Analyses • Introduce Cochrane Database of Systematic Reviews
  4. 4. Source: Evidence-Based Living Blog (Cornell University) http://evidencebasedliving.human.cornell.edu/
  5. 5. Definition Literature Review Systematic Review Qualitatively summarizes evidence on a topic using informal or subjective methods to collect and interpret studies. High-level overview of primary research that identifies, selects, synthesizes, an d appraises all relevant high quality research evidence
  6. 6. Goal Literature Review • Provide summary or overview of topic Systematic Review • Answer a focused clinical question • Eliminate bias
  7. 7. Questio n Literature Review • Can be a general topic or a specific question Systematic Review • Clearly defined and answerable clinical question • Recommend using PICO as a guide
  8. 8. Componen ts Literature Review • Introduction • Methods • Discussion • Conclusion • Reference list Systematic Review • Pre-specified eligibility criteria • Systematic search strategy • Assessment of the validity of findings • Interpretation and presentation of results • Reference list
  9. 9. Hormone therapy for preventing cardiovascular disease in post-menopausal women Main Cm Knight B, Moxham T, Sanchez RG, Sanchez Gomex LM, Figuls MR, Cosp XB.
  10. 10. Hormone therapy for preventing cardiovascular disease in post-menopausal women Main Cm Knight B, Moxham T, Sanchez RG, Sanchez Gomex LM, Figuls MR, Cosp XB.
  11. 11. Literature Review • 1 or more Author s Systematic Review • 3 or more Skills Literature Review • Understanding of topic • Perform searches in one or more database Systematic Review • Thorough knowledge of topic • Perform searches in all relevant database • Statistical analysis resources (meta-analysis)
  12. 12. Tim e Literature Review • Weeks to months Systematic Review • Months to years • Average eighteen months
  13. 13. Valu e Literature Review • Provides summary of the literature on a topic Systematic Review • Connects practicing clinicians to high quality evidence • Supports evidence-based practice
  14. 14. Meta-Analyses Systematic Reviews All Review Articles Adapted from: Pai M, McCulloch M, Gorman JD, Pai N, Enanoria W, Kennedy G, Tharyan P, and Colford JM. “Systematic reviews and meta-analyses: An illustrated, step-by-step guide” The National Medical Journal of India (2004)
  15. 15. Finding review articles: Use “Article Type” filter
  16. 16. Finding systematic reviews: Use Basic Search
  17. 17. Agenda • Distinguish a systematic review from a standard literature review • Locate the following in PubMed • Reviews • Systematic Reviews • Meta-Analyses • Introduce Cochrane Database of Systematic Reviews
  18. 18. Questions? Lynn Kysh, MLIS Information Services Librarian kysh@usc.edu (323) 442-1124
  19. 19. Thanks! Lynn Kysh, MLIS Information Services Librarian kysh@usc.edu (323) 442-1124

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