Excellent

1. BLOOD CLOTTING
Nokhaiz Hammad.
2021-BS-MLS-007.

2. Coagulation or clotting is defined as the
process in which blood losses its fluid
and becomes a jelly like mass few
minutes after it is shed out or
collectedin a container.

4. THIRTEEN CLOTTING FACTORS ARE IDENTIFIED.
1.FACTOR – 1: FIBRINOGEN
1. FACTOR – II: PROTHROMBIN
2. FACTOR – III:THROMBOPLASTIN (TISSUE FACTOR)
3. FACTOR – IV: CALCIUM
4. FACTOR – V: LABILE FACTOR
5. FACTOR – VI: PRESENCE HAS NOT BEEN PROVED
6. FACTOR – VII: STABLE FACTOR
7. FACTOR – VIII:ANTIHEMOPHILLIC FACTOR (ANTIHEMOPHILLIC GLOBULIN)
8. FACTOR – IX:CHRISTMAS FACTOR
9. FACTOR – X: STUART PROWER FACTOR
10. FACTOR – XI: PLASMATHROMBOPLASTINANTECEDENT
11. FACTOR – XII: HAGEMAN FACTOR (CONTACT FACTOR)
12. FACTOR – XIII: FIBRIN STABILIZING FACTOR (FIBRINASE)

5. STEPS OF BLOOD CLOTTING
1)FORMATION OF PROTHROMBIN ACTIVATOR
2)CONVERSION OF PROTHROMBIN INTO THROMBIN
3)CONVERSION OF FIBRINOGEN INTO FIBRIN

6. XII XII A
XI
XI A
IX IX A
X XA
PROTHROMBIN ACTIVATOR
END OTHELIALDAMAGE +COLLAGEN EXPOSURE
TISSUE TRAUMA+ THROMBOPLASTIN
(phospholipid +glycoprotein)
X X A
VII
CALCIUM
V
PHOSPHOLIPID
PLATELETS

7. PROTHROMBIN ACTIVATOR
PROTHROMBIN
+ VE FEED BACK + VE FEED BACK
THROMBIN
CONVERSION OF PROTHROMBIN INTO THROMBIN

8. FIBRINOGEN FIBRINOGEN A
LOOSE STRANDS OF
FIBRIN
THROMBIN
FIBRIN TIGHTS BLOOD
CLOT
POLYMERISATION
FACTOR XIII & CALCIUM
STAGE III -FIBRINOGEN INTO FIBRIN