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A Baffling
Case
Mihail Petrov
Case History
The Patient is a 45-year-old woman
that presents at the emergency
neurosurgery department with a weakness
in her right extremities that started 10 days
ago. Since around 2 to 3 days she has
started experiencing difficulty talking. This is
why she is brought by her husband to the
department.
Clinical Examination
 The clinical examination reveals paresis for the
right extremities much more severe for the
arm.
 Paresis of the right CN VII and CN XII.
 Sensory aphasia
 Sensation in the left and right part of the body
was tested – the patient refused to have a
difference in sensation BUT because of the
aphasia we can’t be 100% sure of that result.
 No pathological reflexes
Our hypothesis
 The clinical examination leads us to think that there is some
kind of a process in the LEFT hemisphere – including the
precentral gyrus(explains the paresis), possible inclusion of
the postcentral gyrus, and the supramarginal gyrus(this
explains the aphasia).
 First a CT scan was order as it was the fastest possible study.
 The symptomatology is consistent with a stroke BUT not the
time frame of the process – we have a history of 10 days of
weakness.
 The lack of high temperature excludes infectious etiology.
 No history of a diagnosed neoplasia gives us evidence to
suspect a brain metastasis.
 The symptoms and their evolution makes us think it is more
likely a tumor that is causing brain swelling and for the last
10 days the oedema has made those symptoms worse.
 Shortly after the CT scan was conducted its result made us a
bit confused and we ordered an MRI to enlighten us. So in
this presentation will be shown slides from this MRI study.
T1 axial T1 axial
T1 coronal T1 coronal
T2 sagittal T2 sagittal
T2 axial T2 axial
 After the MRI study there is a suspicion of
a Glioma.
 An antioedema therapy was started.
Unfortunately with a slight improvement
on the third day.
 The type of operation is still being
discussed.
As a neurosurgical intern I found the course
of Prof. Mason in coursera.org extremely helpful
for a deeper understanding of the basics of
neuroscience and neurology. Every time I read or
hear parts of neuroscience from different sources
it helps me take a look at the matter from a
different perspective, which step by step helps me
to look in to the matter even further.
The assumptions made just after the clinical
examination are to some extend influenced by
the things learned in the course.
Thank You Prof. Mason for the dedication
and for the enthusiasm.

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Left Hemisphere Brain Lesion Case

  • 2. Case History The Patient is a 45-year-old woman that presents at the emergency neurosurgery department with a weakness in her right extremities that started 10 days ago. Since around 2 to 3 days she has started experiencing difficulty talking. This is why she is brought by her husband to the department.
  • 3. Clinical Examination  The clinical examination reveals paresis for the right extremities much more severe for the arm.  Paresis of the right CN VII and CN XII.  Sensory aphasia  Sensation in the left and right part of the body was tested – the patient refused to have a difference in sensation BUT because of the aphasia we can’t be 100% sure of that result.  No pathological reflexes
  • 4. Our hypothesis  The clinical examination leads us to think that there is some kind of a process in the LEFT hemisphere – including the precentral gyrus(explains the paresis), possible inclusion of the postcentral gyrus, and the supramarginal gyrus(this explains the aphasia).  First a CT scan was order as it was the fastest possible study.  The symptomatology is consistent with a stroke BUT not the time frame of the process – we have a history of 10 days of weakness.  The lack of high temperature excludes infectious etiology.  No history of a diagnosed neoplasia gives us evidence to suspect a brain metastasis.  The symptoms and their evolution makes us think it is more likely a tumor that is causing brain swelling and for the last 10 days the oedema has made those symptoms worse.  Shortly after the CT scan was conducted its result made us a bit confused and we ordered an MRI to enlighten us. So in this presentation will be shown slides from this MRI study.
  • 5. T1 axial T1 axial
  • 6. T1 coronal T1 coronal
  • 7. T2 sagittal T2 sagittal
  • 8. T2 axial T2 axial
  • 9.
  • 10.  After the MRI study there is a suspicion of a Glioma.  An antioedema therapy was started. Unfortunately with a slight improvement on the third day.  The type of operation is still being discussed.
  • 11. As a neurosurgical intern I found the course of Prof. Mason in coursera.org extremely helpful for a deeper understanding of the basics of neuroscience and neurology. Every time I read or hear parts of neuroscience from different sources it helps me take a look at the matter from a different perspective, which step by step helps me to look in to the matter even further. The assumptions made just after the clinical examination are to some extend influenced by the things learned in the course. Thank You Prof. Mason for the dedication and for the enthusiasm.