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18%
9%
NCCN Version 6.2018
Stage IV NSCLC
Non-squamous
No mutations EGFR/ALK/ROS1
PS 0-1
Systemic therapy
Bevacizumab/carboplatin/paclitaxel
Bevacizumab/carboplatin/pemetrexed
Bevcizumab/cisplatin/pemetrexed
Carboplatin/albumin-bound paclitaxel
Carboplatin/docetaxel
Carboplatin/etoposide
Carboplatin/Gemcitabine
Carboplatin/paclitaxel
Carboplatin/pemetrexed
Cisplatin/etoposide
Cisplatin/gemcitabine
Cisplatin/paclitaxel
Cisplatin/pemetrexed
Gemcitabine/docetaxel
Gemcitabine/vinorelbine
Pembrolizumab/carboplatin/pemetrexed
Pembrolizumab/cisplatin/pemetrexed
Atezolizumab/carboplatin/paclitaxel/bevacizumab
PCB pCB pcB CNa CDo CE CG PC pC cDo cE cG cP cp GDo GVi 189 c189
PCB 12.3 13.4
pCB 12.6
pcB 15.7
CNa 12.1
CDo 9.4
CE 11
CG 7.7
PC 10.3 11.1 12.3 9.0 7.9
pC 10.5 49%
cDo 11.3 11.3
cE 7.6 7.2 7.9
cG 14.1 8.7 7.9 10.9
cP 7.9
cp 12.6 49%
GDo 11.1
GVi 11.5
189 69%
c189 69%
PCB pCB pcB CNa CDo CE CG PC pC cDo cE cG cP cp GDo GVi 189 c189
PCB 12.3 13.4
pCB 12.6
pcB 15.7
CNa 12.1
CDo 9.4
CE 11
CG 7.7
PC 10.3 11.1 12.3 9.0 7.9
pC 10.5 49%
cDo 11.3 11.3
cE 7.6 7.2 7.9
cG 14.1 8.7 7.9 10.9
cP 7.9
cp 12.6 49%
GDo 11.1
GVi 11.5
189 69%
c189 69%
PCB pCB pcB CNa CDo CE CG PC pC cDo cE cG cP cp GDo GVi 189 c189
PCB 12.3 13.4
pCB 12.6
pcB 15.7
CNa 12.1
CDo 9.4
CE 11
CG 7.7
PC 10.3 11.1 12.3 9.0 7.9
pC 10.5 49%
cDo 11.3 11.3
cE 7.6 7.2 7.9
cG 14.1 8.7 7.9 10.9
cP 7.9
cp 12.6 49%
GDo 11.1
GVi 11.5
189 69%
c189 69%
50% live about 1 year
Close to 70% live more than 1 year
with Pembro + Chemo
Thank you!

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  • 28. NCCN Version 6.2018 Stage IV NSCLC Non-squamous No mutations EGFR/ALK/ROS1 PS 0-1 Systemic therapy Bevacizumab/carboplatin/paclitaxel Bevacizumab/carboplatin/pemetrexed Bevcizumab/cisplatin/pemetrexed Carboplatin/albumin-bound paclitaxel Carboplatin/docetaxel Carboplatin/etoposide Carboplatin/Gemcitabine Carboplatin/paclitaxel Carboplatin/pemetrexed Cisplatin/etoposide Cisplatin/gemcitabine Cisplatin/paclitaxel Cisplatin/pemetrexed Gemcitabine/docetaxel Gemcitabine/vinorelbine Pembrolizumab/carboplatin/pemetrexed Pembrolizumab/cisplatin/pemetrexed Atezolizumab/carboplatin/paclitaxel/bevacizumab
  • 29. PCB pCB pcB CNa CDo CE CG PC pC cDo cE cG cP cp GDo GVi 189 c189 PCB 12.3 13.4 pCB 12.6 pcB 15.7 CNa 12.1 CDo 9.4 CE 11 CG 7.7 PC 10.3 11.1 12.3 9.0 7.9 pC 10.5 49% cDo 11.3 11.3 cE 7.6 7.2 7.9 cG 14.1 8.7 7.9 10.9 cP 7.9 cp 12.6 49% GDo 11.1 GVi 11.5 189 69% c189 69%
  • 30. PCB pCB pcB CNa CDo CE CG PC pC cDo cE cG cP cp GDo GVi 189 c189 PCB 12.3 13.4 pCB 12.6 pcB 15.7 CNa 12.1 CDo 9.4 CE 11 CG 7.7 PC 10.3 11.1 12.3 9.0 7.9 pC 10.5 49% cDo 11.3 11.3 cE 7.6 7.2 7.9 cG 14.1 8.7 7.9 10.9 cP 7.9 cp 12.6 49% GDo 11.1 GVi 11.5 189 69% c189 69%
  • 31. PCB pCB pcB CNa CDo CE CG PC pC cDo cE cG cP cp GDo GVi 189 c189 PCB 12.3 13.4 pCB 12.6 pcB 15.7 CNa 12.1 CDo 9.4 CE 11 CG 7.7 PC 10.3 11.1 12.3 9.0 7.9 pC 10.5 49% cDo 11.3 11.3 cE 7.6 7.2 7.9 cG 14.1 8.7 7.9 10.9 cP 7.9 cp 12.6 49% GDo 11.1 GVi 11.5 189 69% c189 69% 50% live about 1 year Close to 70% live more than 1 year with Pembro + Chemo