diff stages of lung cancer and treatments

1. BHARAT SCHOOL OF PHARMACY
TOPIC - CANCER
GUIDE –VIJAY A LAKSHMI
asst proff,m-pharm
S.MANIKANTH
13CE1ROO57

2. INTRODUCTION
• Cancer is a group of diseases involving abnormal cell
growth with the potential to invade or spread parts of
the body.
• TYPES OF TUMORS:
• Benign tumor(NON CANCEROUS)_CAN NOT
SPREAD
• Malignant tumor(CANCEROUS)-spread in to blood
vessels ,neighboring tissues metastasize to different
sites.

3. TYPES OF CANCERS
CARCINOMA:Cancers derived from epithelial cells. Nearly all
cancers developing in the breast, prostate, lung, pancreas,
and colon are carcinomas.
• SARCOMA: Cancers arising from connective
tissue (i.e. bone, cartilage, fat, nerve), each of which develop
from cells originating inmesenchymal cells outside the bone
marrow.
• LYMPHOMA and LEUKEMIA: These two classes of cancer
arise from cells that make blood. Leukemia is the most common
type of cancer in children accounting for about 30%.]However,
far more adults develop lymphoma and leukemia

4. WHAT IS LUNG CANCER?
1)Cancerous cell that form
In the lining of the lungs.
2)It can be in one or both of
The lungs.
3)Can form cancerous tumors
Which can spread through
metastasis

5. STATISTICS:
*The leading cancerous death
• second most common cancer
• About 200,000 cases annually
• An estimated 159,390 people
• Will die from lung cancer .
0
5
10
15
Category1
Category2
Category3
Category4
Series 3
Series 2
Series 1
1st Qtr
2nd Qtr
3rd Qtr
4th Qtr

6. RISK FACTORS
• Tobacco (cigarette smoking) is the #1 cause
• Radon
• Asbestos exposure
• Pollution
• Age

7. TYPES OF LUNG CANCER
• NON SMALL CELL LUNG CANCER
• Most common type
• About 80-85% are NSLSC
• Grows more slowly
• SMALL CELL LUNG CANCER
• Spreads more quickly and aggressively
• Accounts for 15% cases
• Found in most heavy smokers

8. symptoms
• Chest pain
• Wheezing
• Fatigue
• Loss of appetite
• Continuous cough
• Coughing up blood
• Shortness of breathe

9. DIAGNOSIS & TREATMENT
• Biopsy surgery
• CT scan chemotherapy
• X-ray radiation therapy

10. STAGES OF NSCLC:
Stage 2

11. STAGES

12. STAGES AND TREATMENT OF NSCLC
STAGE DESCRIPTION TREATMENT OPTIONS
STAGE 1 Tumor of any size is found
only in the lung
Surgery
STAGE 2 Tumor has spread to lymph
nodes associated with the
lung
surgery
STAGE 3A Tumor ha spread to the
lymph nodes in the tracheal
area, including chest wall
and diaphragm
surgery or chemotherapy
STAGE 3B Tumor has spread into
lymph nodes on the pop
lung or in the neck
Combination of
chemotherapy and radiation
STAGE 4 Tumor has spared beyond
the chest
Chemotherapy only

13. SURVIVAL RATE
Statistics on the outlook for a certain type and stage of cancer are
often given as 5-year survival rates, but many people live longer –
often much longer – than 5 years. The 5-year survival rate is the
percentage of people who live at least 5 years after being diagnosed
with cancer

14. Drugs approved for NSCLC
• Abitrexate [METHOTREXATE]
• Alectinib
• Docetaxcel
• Geftinib
• Opdivo

15. USUAL ADULT DOSE FOR NSCLC
• FOUR WEEKS SCHEDULE:1000mg/m2 IV over
30Minutes on days 1,8,AND 15 combination
• CISPALTIN THERAPY.
• THREE WEEKS SCHEDULE:1250 mg/m2 IV over
30 minutes on days 1 and 8 in combination
with CISPLATIN THERAPY

16. CONCLUSION
• Lung cancer is the most common cause of cancer-
related deaths and attempts to prevent this by ridding
society of tobacco smoking have not yet changed this
fact. This review focused on past progress and
ongoing research in the treatment of locally
advanced, inoperable NSCLC. Significant
improvements in care include the use of moderate
dose (60 Gy/30 fractions) photon TRT administered
concurrently with platinum-based therapy. However,
further research on methods of dose-intensification
(hypofractionation, adaptive TRT, stereotactic TRT
boosting) is proceeding and may improve outcomes.

17. REFERENCES
• Subramanian,j: govindan, R. [2007]lung cancer in
never smokers a review. Journal of clinical
oncology. [25]5
• Wolf J, Patno ME, Roswit B, D’Esopo N. Controlled study
of survival of patients with clinically inoperable lung
cancer treated with radiation therapy. Am J Med 1966;
40: 360–36
• "Non-small cell lung cancer treatment - National Cancer
Institute". Retrieved 2008-10-19.
• "National Cancer Institute Non-Small Cell Lung Cancer
Treatment (PDQ®)". Retrieved 12 May 2015.