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A Big Blind Spot inA Big Blind Spot in
AnticoagulationAnticoagulation
GuidelinesGuidelines
Aching Joints inAching Joints in
Diabetes: What Drug IsDiabetes: What Drug Is
at Fault?at Fault?
Smoking and Seizures:Smoking and Seizures:
Where the EvidenceWhere the Evidence
StandsStands
Vitamin D: Time forVitamin D: Time for
Rational Decision-Rational Decision-
MakingMaking
PrintPrint EmailEmail
Drugs & Therapy Perspectives
[1,2,18-21]
MOST POPULAR ARTICLES
According to FAMILYMEDICINE PHYSICIANS
Whistleblower Doctor Warns About
Hospitals Hiring Physicians
1.
Vitamin D: Time for Rational Decision-
Making
2.
High-Spending Doctors Less Likely to3.
Drug Ther Perspect. 2001;17(20)
In Brief and Introduction
Levosimendan Boosts
Contractility
Favourable Pharmacokinetics
Best Results in
Decompensated CHF
May Be Useful in Stable CHF...
Good Tolerability Profile
Adis Evaluation
Differential features
References
RELATED DRUGS & DISEASES
Levosimendan http://www.medscape.com/viewarticle/406544_10
1 of 3 12.11.2015 11:01
10 of 10Previous Page
Feature Levosimendan Milrinone Dobutamine
Class Calcium sensitiser Phosphodiesterase inhibitor Catecholamine
Increases intracellular
calcium
concentrations?
No Yes Yes
Increases cardiac
contractility?
Yes Yes Yes
Vasodilator? Coronary and systemic Peripheral Mild peripheral
Increase myocardial
oxygen demand?
No No Yes
Arrhythmogenic
potential
No evidence of
arrhythmogenesis to
date
Ventricular (12.1%) and
supraventricular arrhythmias
(3.8%)
Ventricular ectopic activity
(5%); less arrhythmogenic
than milrinone
Available formulations IVa IV, PO IV
Drug interactions? No clinically important
interactions reported
Few clinically important
interactions
No clinically important
interactions reported
Can be given with
ß-blockers?
Yes Yes Yes
Adverse events Headache, hypotension Ventricular irregularities,
hypotension, headache
Tachycardia and increased
SBP on overdosage
a An oral formulation is under development
IV = intravenously; PO = orally; SBP = systolic blood pressure.
Be Sued
10 New Malpractice Concerns, and Ho
to Avoid Them
4.
Acupuncture, Alexander Technique
Effective in Neck Pain
5.
VIEW MOR
Apolipoprotein B
Apolipoprotein A-I
Levosimendan http://www.medscape.com/viewarticle/406544_10
2 of 3 12.11.2015 11:01
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About Medscape Privacy Policy Terms of Use WebMD Medscape France Medscape Deutschland MedicineNet eMedicineHealth RxList WebMD Corporate He
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LATEST IN INTERNAL MEDICINE
Calculator Pegs Diabetics' Risk for Blindness and Amputations
Sophiris's Prostate Drug Meets Main Goal in Late-Stage Study
Babies' Introduction to Gluten Not Tied to Celiac Risk
El Nino Threatens 11 Million Children in Africa With Hunger, Disease: U.N.
Many U.S. Veterans May Face Sexual Health Problems
Drug Ther Perspect. 2001;17(20) © 2001 Adis Data Information BV
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3 of 3 12.11.2015 11:01

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Vitamin D Time Rational Decision Making

  • 1. A Big Blind Spot inA Big Blind Spot in AnticoagulationAnticoagulation GuidelinesGuidelines Aching Joints inAching Joints in Diabetes: What Drug IsDiabetes: What Drug Is at Fault?at Fault? Smoking and Seizures:Smoking and Seizures: Where the EvidenceWhere the Evidence StandsStands Vitamin D: Time forVitamin D: Time for Rational Decision-Rational Decision- MakingMaking PrintPrint EmailEmail Drugs & Therapy Perspectives [1,2,18-21] MOST POPULAR ARTICLES According to FAMILYMEDICINE PHYSICIANS Whistleblower Doctor Warns About Hospitals Hiring Physicians 1. Vitamin D: Time for Rational Decision- Making 2. High-Spending Doctors Less Likely to3. Drug Ther Perspect. 2001;17(20) In Brief and Introduction Levosimendan Boosts Contractility Favourable Pharmacokinetics Best Results in Decompensated CHF May Be Useful in Stable CHF... Good Tolerability Profile Adis Evaluation Differential features References RELATED DRUGS & DISEASES Levosimendan http://www.medscape.com/viewarticle/406544_10 1 of 3 12.11.2015 11:01
  • 2. 10 of 10Previous Page Feature Levosimendan Milrinone Dobutamine Class Calcium sensitiser Phosphodiesterase inhibitor Catecholamine Increases intracellular calcium concentrations? No Yes Yes Increases cardiac contractility? Yes Yes Yes Vasodilator? Coronary and systemic Peripheral Mild peripheral Increase myocardial oxygen demand? No No Yes Arrhythmogenic potential No evidence of arrhythmogenesis to date Ventricular (12.1%) and supraventricular arrhythmias (3.8%) Ventricular ectopic activity (5%); less arrhythmogenic than milrinone Available formulations IVa IV, PO IV Drug interactions? No clinically important interactions reported Few clinically important interactions No clinically important interactions reported Can be given with ß-blockers? Yes Yes Yes Adverse events Headache, hypotension Ventricular irregularities, hypotension, headache Tachycardia and increased SBP on overdosage a An oral formulation is under development IV = intravenously; PO = orally; SBP = systolic blood pressure. Be Sued 10 New Malpractice Concerns, and Ho to Avoid Them 4. Acupuncture, Alexander Technique Effective in Neck Pain 5. VIEW MOR Apolipoprotein B Apolipoprotein A-I Levosimendan http://www.medscape.com/viewarticle/406544_10 2 of 3 12.11.2015 11:01
  • 3. MORE About Medscape Privacy Policy Terms of Use WebMD Medscape France Medscape Deutschland MedicineNet eMedicineHealth RxList WebMD Corporate He All material on this website is protected by copyright, Copyright © 1994-2015 by WebMD LLC. This website also contains material copyrighted by 3rd parties. We have updated the Medscape Terms of Use which you may access HERE. By using Medscape, you agree to the Medscape Terms of Use. close This website uses cookies to deliver its services as described in our Cookie Policy. By using this website, you agree to the use of cookies. close LATEST IN INTERNAL MEDICINE Calculator Pegs Diabetics' Risk for Blindness and Amputations Sophiris's Prostate Drug Meets Main Goal in Late-Stage Study Babies' Introduction to Gluten Not Tied to Celiac Risk El Nino Threatens 11 Million Children in Africa With Hunger, Disease: U.N. Many U.S. Veterans May Face Sexual Health Problems Drug Ther Perspect. 2001;17(20) © 2001 Adis Data Information BV Levosimendan http://www.medscape.com/viewarticle/406544_10 3 of 3 12.11.2015 11:01