An brief introduction to carrying out a simple search with a focus on identify pharmacological bioactivity and uses data.

1. Reaxys retrieves and summarises chemistry
information from available data sources and
published literature.
For instance, for each type of substance:
You can review a range of chemical properties;
You can view citations that discuss treatment use
and application and pharmacological bioactivity;
You can follow references back to original sources.

2. Search for Reaxys from
OneSearch and follow the
View Online link to it.

3. To begin a basic search in Reaxys type in your Drug name
A search for “Rapivab” finds 3 citations

4. A review of the title/abstract information for these reveals that
“Permavir” is the a common name for the active drug.
Carry out a search for
the active drug

5. Reaxys has identified 14 substances on a search of “Peramivir”
with a similar molecular formula

6. There are a number of options for
you to filter the data but the most
useful may be by limiting
“Bioactivty” to Pharmacological
data and results.
This reduces results to 11
substances, based on 65
total citations
Now we will look more
closely at the citations
associated with substance
record for “Peramivir”

7. Click on show details and
pharmacological data to open up the
9 related records.
The first of these is a list of reference.
Clicking on a Title/Abstract can
provide good summary information
about an article.
Note any useful Emtree (Embase) and
Medline search terms.

8. Following on from the reference list is the remaining
entries summarizing the tested
pharmacological impacts of this drug
It may also be useful exploring the
“Uses/applications”
citation links for your drug.
In this instance it becomes clear
research and patents into use of
“Peramiver” is dominated by two
main research bodies.
You could extend your research by
searching for papers by them?
Search OneSearch, Medline or Embase for full-text