The technology innovation alert by DexPatent gives you a thorough and comprehensive analysis of a technology space with patents published, granted or expired by companies, start-ups, inventors or universities across the world during 06 - 12 Jul, 2018 . This Exclusive report provides you patent and technology insights which helps you take direct decisions relating to R&D alignment, licensing or acquisition. To get in-depth analysis of innovations and opportunities relating to Connected Insulin Delivery System, Please contact mano@dexpatent.com

1. April 27, 2018 to May 03, 2018
5
2
0
E x p i r e d
G r a n t e d
P u b l i s h e d
P a t e n t s
Start ups Companies Universities Individuals
41 0 0
C o n n e c te d I n s u l i n D e l i v e r y S y st e m
Technology Innovation Alert
6 July– 12 July, 2018
Interesting
Innovation
Compliance with regulations

2. April 27, 2018 to May 03, 2018
July 06, 2018 to July 12, 2018 2
Technology Innovation Alert: Connected insulin delivery system
Active players of the week
• Medtrum
• Abbott diabetes care
United states
Most filed jurisdiction
Highlights of the week
Large companies
• Tandem diabetic care
• Abbott diabetes care
• Novo Nordisk
Start-ups
InnoMD
Small & Medium Enterprises
Medtrum

3. April 27, 2018 to May 03, 2018
July 06, 2018 to July 12, 2018 3
Technology Innovation Alert: Connected insulin delivery system
China
United states
Patents protected under jurisdictions in this
week
Highlights of the week

4. April 27, 2018 to May 03, 2018
July 06, 2018 to July 12, 2018 4
Technology Innovation Alert: Connected insulin delivery system
Problems and its proposed solutions in this week
Clinical variables (insulin sensitivity factor &
carbohydrate factor) determined by manual
method
Automating or partially automating determination
of values for clinical variable by instructing the
patient through a process of determination
Difficulties in determination of carbohydrate
content for each part of the meal
Compiling a database of meal records that does
not comprise carbohydrate content of meal
Presence of time delay and inaccuracy in
artificial pancreas
Construction of an auto-regression model to
describe the insulin concentration

5. April 27, 2018 to May 03, 2018
July 06, 2018 to July 12, 2018 5
Technology Innovation Alert: Connected insulin delivery system
Problems and its proposed solutions in this week
Measurement of concentration easily
affected by patient actions for continuous
glucose monitoring in interstitial fluid
Detecting activity level of patient for motion
compensation
Inconvenience in keeping track of time when
insulin was injected
Unique design of insulin injecting device with
a wearing module, detection module and
administration module

6. April 27, 2018 to May 03, 2018
July 06, 2018 to July 12, 2018 6
Technology Innovation Alert: Connected insulin delivery system
Problems and its proposed solutions in this week
Integration of communication or software
part within medical product requires renewed
approval of entire product during updates
Medical and communication part are connected
by predetermined protocol for data exchange and
functionalities of each part are separated
Power management and shelf life in
continuous or automatic monitoring of
analytes
Determining when to activate an analyte
alarm of a continuous analyte monitor

7. April 27, 2018 to May 03, 2018
July 06, 2018 to July 12, 2018 7
Technology Innovation Alert: Connected insulin delivery system
DexPatent Findings – Areas of Innovation
Highlights of the week
• Master-Slave
• PID algorithm
• Glycemic event
• Raman spectrum
• Alarm activation
• Power management
• Activity monitoring
• Closed-loop control
• Information exchange
• Needle-free injector
• Auto-regressive model
• Infusion dose control
• Communication Protocol
• Medical recommendation
• Classification of meals
• Insulin dose determination
• Insulin sensitivity factor
• Insulin dose recommendation
• Compliance with regulations
• Different modes of operation
• Blood glucose level detection
• Continuous glucose monitoring
• Insulin to carbohydrate ratio
• Meal-related analyte response
• Blood glucose trend prediction
• User guidance via infusion pump

8. April 27, 2018 to May 03, 2018
July 06, 2018 to July 12, 2018 8
Technology Innovation Alert: Connected insulin delivery system
X`
A method of determining clinical variables to control an
infusion pump includes instructing a user on
carbohydrate intake; obtaining amount of
carbohydrate intake in current and subsequent meal
from user; obtaining glucose level data before and
after intake of carbohydrates from a CGM; and
determining the amount of insulin dose to be infused.
Innovation Involves
✓ Insulin sensitivity factor
✓ Insulin to carbohydrate ratio
✓ User guidance via infusion pump
✓ Continuous glucose monitoring
✓ Infusion dose control
Infusion Pump control
Utility AreaBy Company
DexPatent Abstract
U S 1 0 0 1 6 5 6 1 1Patent Family Count

9. April 27, 2018 to May 03, 2018
July 06, 2018 to July 12, 2018 9
Technology Innovation Alert: Connected insulin delivery system
X`
A method of determining and administering insulin
dose based on meal consumption information and
glucose data. Meal consumed by user and insulin dose
administered for that meal is stored in a database as
meal record that does not contain a carbohydrate
content and each meal record is classified as one of a
plurality of menu items. Insulin doses are
recommended based on meal selected by user in an
electronic device.
Innovation Involves
✓ Insulin dose recommendation
✓ Classification of meals
✓ Meal-related analyte response
Insulin dose control
Utility AreaBy Company
DexPatent Abstract
U S 2 0 1 8 0 1 9 7 6 2 8 1Patent Family Count

10. April 27, 2018 to May 03, 2018
July 06, 2018 to July 12, 2018 10
Technology Innovation Alert: Connected insulin delivery system
X`
A closed loop control method to control insulin pump
comprises obtaining real-time measurements of blood
glucose from CGM; calculating the estimated insulin
concentration; predicting blood glucose trend variation
using auto-regressive model; and calculating required
amount of insulin infusion using PID controller.
Innovation Involves
✓ Closed-loop algorithm
✓ Auto-regressive model
✓ PID algorithm
✓ Blood glucose trend prediction
✓ Infusion volume determination
Artificial Pancreas
Utility AreaBy Small & Medium Enterprises
DexPatent Abstract
C N 1 0 8 2 6 1 5 9 1 1Patent Family Count

11. April 27, 2018 to May 03, 2018
July 06, 2018 to July 12, 2018 11
Technology Innovation Alert: Connected insulin delivery system
X`
A closed-loop control method for artificial pancreas
uses activity level of patient determined using a motion
sensor to adjust a correlation algorithm and switch the
mode of operation of the artificial pancreas.
Innovation Involves
✓ Closed-loop control
✓ Activity monitoring
✓ Different modes of operation
✓ Dynamic blood glucose
monitoring
Artificial Pancreas
Utility Area
DexPatent Abstract
C N 1 0 8 2 6 1 5 8 5 1Patent Family Count
By Small & Medium Enterprises

12. April 27, 2018 to May 03, 2018
July 06, 2018 to July 12, 2018 12
Technology Innovation Alert: Connected insulin delivery system
X`
An insulin injection device comprises a wearable
module, detection module and dose administration
module. The detection module monitors blood glucose
level using a Raman spectrum and determines the
amount of insulin to be administered. The dose
administration module administers corresponding
doses of insulin. The construction of the three modules
are characterized.
Innovation Involves
✓ Blood glucose level detection
✓ Raman spectrum
✓ Needle-free injector
✓ Insulin dose determination
Insulin Injecting Device
Utility AreaBy Start-Up
DexPatent Abstract
C N 1 0 8 2 4 5 7 4 2 1Patent Family Count

13. April 27, 2018 to May 03, 2018
July 06, 2018 to July 12, 2018 13
Technology Innovation Alert: Connected insulin delivery system
X`
A method of communicating medical data information
(e.g. glucose value) of an integrated medical device
having medical and communication part connected via
physical interfaces. The medical part includes
continuous body fluid monitoring & drug
administration apparatus and exchanges data with
communication part according to a predetermined
protocol, where medical and communication part act
as master and slave.
Innovation Involves
✓ Communication Protocol
✓ Approval of medical products
✓ Information exchange
✓ Master-Slave
Medical information
Exchange
Utility AreaBy Company
DexPatent Abstract
U S 1 0 0 1 6 1 3 4 15Patent Family Count

14. April 27, 2018 to May 03, 2018
July 06, 2018 to July 12, 2018 14
Technology Innovation Alert: Connected insulin delivery system
X`
A method of determining when to activate an analyte-
related alarm (e.g. glucose) includes receiving analyte
concentration from analyte sensor; determining a best-
estimate; checking whether user analyte concentration
and best-estimate are in agreement and accordingly
implementing an alarm.
Innovation Involves
✓ Medical recommendation
✓ Alarm activation
✓ Continuous glucose Monitor
✓ Power management
✓ Glycemic event
Alarm Prevention
Mechanism
Utility AreaBy Company
DexPatent Abstract
U S 2 0 1 8 1 9 2 9 6 3 4Patent Family Count

15. April 27, 2018 to May 03, 2018
July 06, 2018 to July 12, 2018 15
Technology Innovation Alert: Connected insulin delivery system
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